SMN1 and HNRNPU

Number of citations of the paper that reports this interaction (PMID 8670859)
146

Data Source:
HPRD (two hybrid, in vivo)

		SMN1	HNRNPU
Gene Name		survival of motor neuron 1, telomeric	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cajal Body Z Disc SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies	Nucleus Nucleoplasm Cell Surface Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Core Promoter Binding DNA Binding RNA Binding Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly Nervous System Development Gene Expression NcRNA Metabolic Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing RNA Splicing Gene Expression Circadian Regulation Of Gene Expression CRD-mediated MRNA Stabilization
Pathways		snRNP Assembly Metabolism of non-coding RNA	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		136 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 APLP1 ARFGAP1 ATP5B ATP6V1A BAG6 BCL2 C19orf60 CARHSP1 CCDC90B CENPB COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EIF3G EXT2 EZH2 FAM20C FBL FGB FLAD1 FUBP1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 HADHB HIST3H3 HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NGFR NKIRAS2 NMT2 OSTF1 PDE4DIP PKM PLXNA3 POLR2A POP7 PSME1 QARS RBBP4 RBBP6 RBFOX2 RBM48 RN7SL1 RNU1-1 RNU2-1 RPL13 RPS2 RXRA SDF4 SEMA5B SETDB1 SMC5 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNUPN SP110 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 WDR18 WDR73 WDYHV1 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC	35 interactors: ACTB BTRC CASP3 CD5 CDKN2A CR2 ELL EP300 ERG GAS7 GRIN1 GRIN2D GTF2H1 HNRNPD HNRNPH3 IL7R KAT2B NDN NDRG1 NEDD4 NR3C1 PIN1 POLR2A POU3F4 PRMT1 PRPF40A PTPN11 SMN1 SREK1 STAU1 SYK TCERG1 WBP4 YAP1 ZNF689
Entrez ID		6606	3192
HPRD ID		02646	04185
Ensembl ID		ENSG00000172062	ENSG00000153187
Uniprot IDs		B4DP61 Q16637	Q00839 Q96BA7
PDB IDs		1G5V 1MHN 2LEH 3S6N 4A4E 4A4G 4GLI	1ZRJ
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Macromolecular Complex Assembly Histone MRNA Metabolic Process Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Process Nuclear-transcribed MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly MRNA Catabolic Process RNA Catabolic Process CRD-mediated MRNA Stabilization Regulation Of Protein Metabolic Process Termination Of RNA Polymerase II Transcription Regulation Of Cellular Protein Metabolic Process DNA-templated Transcription, Termination RNA Biosynthetic Process MRNA 3'-end Processing Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Transcription, DNA-templated RNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Spliceosomal Complex Assembly Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Developmental Process Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Cell Differentiation Catabolic Process	RNA Metabolic Process Developmental Process Gene Expression Regulation Of Cell Cycle Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Viral Process MRNA Processing Multicellular Organismal Development Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Splicing Positive Regulation Of Viral Transcription Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process System Development MRNA Metabolic Process Positive Regulation Of Gene Expression Viral Process Positive Regulation Of Cellular Metabolic Process Signal Transduction RNA Processing Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Regulation Of Cellular Process RNA Biosynthetic Process Cellular Response To Stimulus Cellular Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Regulation Of Viral Process Transcription From RNA Polymerase II Promoter Regulation Of Viral Transcription Regulation Of T Cell Activation Signaling Transcription Initiation From RNA Polymerase II Promoter Cell Communication Regulation Of Metabolic Process Cellular Metabolic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process
Tagcloud ?		atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness	17p13 1q21 1q44 2q23 2q31 agilent annotations asd autism backgrounds cgh cnv cnvs disabilities dissect encephalopathy epileptic exome expand hallux implicates infantile intellectual lissencephaly mbd5 microcephaly pafah1b1 pathogenicity spasms
Tagcloud (Difference) ?		atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness	17p13 1q21 1q44 2q23 2q31 agilent annotations asd autism backgrounds cgh cnv cnvs disabilities dissect encephalopathy epileptic exome expand hallux implicates infantile intellectual lissencephaly mbd5 microcephaly pafah1b1 pathogenicity spasms
Tagcloud (Intersection) ?