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GAPDH and HES1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
GAPDH
HES1
Description
glyceraldehyde-3-phosphate dehydrogenase
hes family bHLH transcription factor 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Cytoskeleton
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Nuclear Membrane
Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
GAIT Complex
Ribonucleoprotein Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
Protein-containing Complex
Molecular Function
Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity
Protein Binding
Microtubule Binding
Oxidoreductase Activity
Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor
Transferase Activity
Aspartic-type Endopeptidase Inhibitor Activity
Peptidyl-cysteine S-nitrosylase Activity
Identical Protein Binding
NADP Binding
NAD Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity
Transcription Corepressor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Protein Binding
JUN Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
HLH Domain Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
Protein Dimerization Activity
Protein-folding Chaperone Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
N-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Microtubule Cytoskeleton Organization
Positive Regulation Of Cytokine Production
Immune System Process
Glucose Metabolic Process
Glycolytic Process
Regulation Of Translation
Apoptotic Process
Negative Regulation Of Endopeptidase Activity
Regulation Of Macroautophagy
Negative Regulation Of Translation
Killing Of Cells Of Another Organism
Positive Regulation Of Type I Interferon Production
Peptidyl-cysteine S-trans-nitrosylation
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Protein Stabilization
Defense Response To Fungus
Neuron Apoptotic Process
Killing By Host Of Symbiont Cells
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Cellular Response To Type II Interferon
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Cell Fate Determination
Liver Development
Inhibition Of Neuroepithelial Cell Differentiation
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Pancreatic A Cell Differentiation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
Pattern Specification Process
Nervous System Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Response To Virus
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Neuron Projection Development
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Cajal-Retzius Cell Differentiation
Neural Tube Development
Central Nervous System Neuron Differentiation
Pituitary Gland Development
Adenohypophysis Development
Neuron Differentiation
Lung Development
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Pancreas Development
Somatic Stem Cell Population Maintenance
Hair Cell Differentiation
Amacrine Cell Differentiation
Aorta Morphogenesis
Ascending Aorta Morphogenesis
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
Inner Ear Auditory Receptor Cell Differentiation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Protein-containing Complex Assembly
Response To Alkaloid
Positive Regulation Of DNA Binding
Cell Fate Commitment
Negative Regulation Of Cell Differentiation
Regulation Of Fat Cell Differentiation
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Regulation Of Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Glial Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Cell Maturation
Regulation Of Timing Of Cell Differentiation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Negative Regulation Of Neurogenesis
Inner Ear Receptor Cell Stereocilium Organization
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Neuroendocrine Cell Differentiation
Stomach Neuroendocrine Cell Differentiation
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Protein-containing Complex Assembly
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Fatty Acid
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Establishment Of Epithelial Cell Polarity
Negative Regulation Of Calcium Ion Import
Response To Thyroid Hormone
Vascular Associated Smooth Muscle Cell Development
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Amacrine Cell Differentiation
Response To Aroclor 1254
Negative Regulation Of Cell Fate Determination
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Negative Regulation Of Inner Ear Receptor Cell Differentiation
Pathways
Glycolysis
Gluconeogenesis
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
NADH
Adenosine-5-Diphosphoribose
Thionicotinamide-Adenine-Dinucleotide
4-(2-Aminoethyl)Benzenesulfonyl Fluoride
Xanthinol
Copper
Artenimol
Diseases
GWAS
Blood protein levels (
30072576
)
Alcoholic chronic pancreatitis (
28754779
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Interacting Genes
92 interacting genes:
ACD
ACTB
ACTC1
ANXA1
ANXA7
APP
AR
ARL15
ATN1
ATXN1
BID
BPGM
BTBD2
CAMK1
CAMK2B
CAMK4
CDKN1A
CDKN2A
CEBPA
CHP1
DUX4
DYNLL1
EGFR
ERBB2
FBXO7
FKBP6
FOXP1
GADD45A
GAS7
GOT2
GRIA2
GRM1
HES1
HNF4G
HSPB2
HTT
ITGB5
KARS1
KAT5
KCNE3
LAMA4
LAMTOR5
LIG4
LINC01554
MAPK1
MTNR1A
MYOC
NFYC
NR1H4
NUFIP2
OGT
OSMR
OSTF1
PAFAH1B3
PCDHA4
PCNA
PDIA2
PGK1
PLD2
POT1
POU2F2
PPM1E
PRDX1
PRKCI
PRPF40A
PSEN1
PSMD11
PTPRF
RAB2A
RBM5
RPA2
RXFP4
S100A6
SERPINB9
SHANK3
SIAH1
SIRT1
SLC2A1
SLC2A4
SMARCA2
SMN1
SUMO4
TERF1
TINF2
TK1
TPPP
TSC2
TXNIP
USP25
WEE2-AS1
YWHAE
YWHAQ
36 interacting genes:
ALK
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NHLH2
NR4A1
NUDT3
PRKCA
PTK2
RUNX2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
Entrez ID
2597
3280
HPRD ID
00713
00770
Ensembl ID
ENSG00000111640
ENSG00000114315
Uniprot IDs
P04406
V9HVZ4
Q14469
PDB IDs
1U8F
1ZNQ
3GPD
4WNC
4WNI
6ADE
6IQ6
6M61
6YND
6YNE
6YNF
6YNH
8DNS
8G12
8G13
8G14
8G15
8G16
8G17
8P5F
2MH3
7C4O
Enriched GO Terms of Interacting Partners
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Developmental Process
Cellular Developmental Process
Nucleus
Cell Differentiation
Regulation Of Programmed Cell Death
Regulation Of Phosphorus Metabolic Process
Shelterin Complex
Regulation Of Cellular Component Organization
Negative Regulation Of Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of DNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Identical Protein Binding
Nuclear Telomere Cap Complex
Protein-containing Complex
Regulation Of Cellular Localization
Cellular Response To Stress
Regulation Of Cellular Response To Stress
Regulation Of Multicellular Organismal Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Protein Localization
Regulation Of DNA Metabolic Process
Telomeric DNA Binding
Telomere Capping
Regulation Of Phosphorylation
Nucleoplasm
Regulation Of Developmental Process
Negative Regulation Of DNA Biosynthetic Process
DNA Biosynthetic Process
Telomere Assembly
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle
Regulation Of Chromosome Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Phosphate Metabolic Process
Regulation Of Cell Population Proliferation
Negative Regulation Of Biosynthetic Process
Cytosol
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Signaling
Positive Regulation Of Chromosome Organization
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Development
Positive Regulation Of Cellular Component Organization
System Development
Fanconi Anaemia Nuclear Complex
Regulation Of Cell Differentiation
Transcription Regulator Inhibitor Activity
Nucleus
Protein Dimerization Activity
Transcription Corepressor Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Population Proliferation
Interstrand Cross-link Repair
Animal Organ Development
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Population Proliferation
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cell Differentiation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Chromatin
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Cellular Developmental Process
Developmental Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Epithelial Cell Proliferation
Nucleoplasm
Cell Differentiation
Regulation Of Developmental Process
Circadian Rhythm
Regulation Of Primary Metabolic Process
Regulation Of Multicellular Organismal Development
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Development
Transcription Regulator Complex
Neuron Differentiation
Rhythmic Process
Animal Organ Morphogenesis
Positive Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Signal Transduction
Negative Regulation Of Developmental Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Apoptotic Process
Response To Stress
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Gene Expression
Anatomical Structure Morphogenesis
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