SMN1 and ZXDC

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SMN1	ZXDC
Description		survival of motor neuron 1, telomeric	ZXD family zinc finger C
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Perikaryon Gemini Of Cajal Bodies	Nucleus
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding LRR Domain Binding Metal Ion Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly DNA-templated Transcription Termination MRNA Processing Nervous System Development RNA Splicing	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription
Pathways		snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs		Nusinersen
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS			Metabolite levels ( 23823483) Pursuit maintenance gain ( 29064472)
Interacting Genes		166 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 ANXA2 APLP1 ARFGAP1 ATP5F1B ATP6V1A BAG6 BCL2 BLOC1S6 BYSL CARHSP1 CCDC90B CENPB CHTOP COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EEF1A2 EHHADH EIF3G EXT2 EZH2 FAM20C FAM9B FBL FGB FLAD1 FNDC11 FUBP1 FXR1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 H3-4 HADHB HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K IQUB ITCH JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAGED1 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NEURL2 NGFR NKIRAS2 NMT2 NRN1 NTAQ1 OSTF1 PDE4DIP PKM PLXNA3 POLR1C POLR2A POP7 PPIG PSME1 QARS1 RBBP4 RBBP6 RBFOX2 RBM48 REX1BD RN7SL1 RNU1-1 RNU11 RNU2-1 RNU4-1 RPL13 RPS2 RXRA SCARNA1 SDF4 SELENOW SEMA5B SETDB1 SMC5 SMN2 SNORA81 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNU13 SNUPN SP110 SPANXN2 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TERC TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 VPS28 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC	17 interacting genes: APP ATXN1 CBR4 CIITA JTB MEPE MTDH NR1H2 NR1H3 POGZ RORA SH3GL2 SMN1 SUOX TK1 WDR5 ZMYND19
Entrez ID		6606	79364
HPRD ID		02646	14420
Ensembl ID		ENSG00000172062	ENSG00000070476
Uniprot IDs		B4DP61 E7EQZ4 Q16637	Q2QGD7
PDB IDs		1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 7W2P 7W30
Enriched GO Terms of Interacting Partners?		Spliceosomal SnRNP Assembly RNA Binding MRNA Metabolic Process RNA Splicing MRNA Processing RNA Splicing, Via Transesterification Reactions SMN-Sm Protein Complex RNA Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome RNA Metabolic Process U2-type Precatalytic Spliceosome Spliceosomal Complex Lsm2-8 Complex Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process U6 SnRNP Lsm1-7-Pat1 Complex Nucleoplasm Precatalytic Spliceosome SMN Complex U4 SnRNP Catalytic Step 2 Spliceosome Telomerase Holoenzyme Complex U7 SnRNP Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Small Nuclear Ribonucleoprotein Complex Nucleus Gemini Of Cajal Bodies Methylosome U12-type Spliceosomal Complex PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex Cytosol U2 SnRNP Spliceosomal Complex Assembly Protein-containing Complex Assembly U1 SnRNP U7 SnRNA Binding U5 SnRNP Cytoplasm Cajal Body Histone Pre-mRNA DCP Binding U2-type Prespliceosome Assembly Protein-containing Complex Organization U6 SnRNA Binding Promoter-specific Chromatin Binding	Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of DNA-templated Transcription Nuclear Receptor Activity Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cholesterol Storage Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Macrophage Derived Foam Cell Differentiation Protein Tetramerization Regulation Of Response To Endoplasmic Reticulum Stress Sterol Homeostasis Cholesterol Homeostasis Phosphatidylcholine Acyl-chain Remodeling Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Regulation Of Triglyceride Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Endocytosis Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cholesterol Efflux Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Metabolic Process Lipid Homeostasis Positive Regulation Of Cholesterol Transport Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Inflammatory Response Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Biosynthetic Process Acylglycerol Homeostasis Negative Regulation Of Inflammatory Response Triglyceride Homeostasis Regulation Of Triglyceride Metabolic Process Amyloid-beta Complex
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