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GAPDH and TXNIP
Number of citations of the paper that reports this interaction (PubMedID
31669268
)
0
Data Source:
BioGRID
(two hybrid)
GAPDH
TXNIP
Description
glyceraldehyde-3-phosphate dehydrogenase
thioredoxin interacting protein
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Cytoskeleton
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Nuclear Membrane
Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
GAIT Complex
Ribonucleoprotein Complex
Nucleus
Cytoplasm
Cytosol
Molecular Function
Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity
Protein Binding
Microtubule Binding
Oxidoreductase Activity
Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor
Transferase Activity
Aspartic-type Endopeptidase Inhibitor Activity
Peptidyl-cysteine S-nitrosylase Activity
Identical Protein Binding
NADP Binding
NAD Binding
Disordered Domain Specific Binding
Enzyme Inhibitor Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
Microtubule Cytoskeleton Organization
Positive Regulation Of Cytokine Production
Immune System Process
Glucose Metabolic Process
Glycolytic Process
Regulation Of Translation
Apoptotic Process
Negative Regulation Of Endopeptidase Activity
Regulation Of Macroautophagy
Negative Regulation Of Translation
Killing Of Cells Of Another Organism
Positive Regulation Of Type I Interferon Production
Peptidyl-cysteine S-trans-nitrosylation
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Protein Stabilization
Defense Response To Fungus
Neuron Apoptotic Process
Killing By Host Of Symbiont Cells
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Cellular Response To Type II Interferon
Negative Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Inflammatory Response
Response To Oxidative Stress
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Glucose
Protein Transport
Keratinocyte Differentiation
Response To Estradiol
Response To Progesterone
Regulation Of Cell Population Proliferation
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Platelet-derived Growth Factor Receptor Signaling Pathway
Response To Calcium Ion
Negative Regulation Of Cell Division
Cellular Response To Tumor Cell
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Pathways
Glycolysis
Gluconeogenesis
The NLRP3 inflammasome
The NLRP3 inflammasome
Regulation of FOXO transcriptional activity by acetylation
Purinergic signaling in leishmaniasis infection
Purinergic signaling in leishmaniasis infection
Cytoprotection by HMOX1
Drugs
NADH
Adenosine-5-Diphosphoribose
Thionicotinamide-Adenine-Dinucleotide
4-(2-Aminoethyl)Benzenesulfonyl Fluoride
Xanthinol
Copper
Artenimol
Diseases
GWAS
Blood protein levels (
30072576
)
Interacting Genes
92 interacting genes:
ACD
ACTB
ACTC1
ANXA1
ANXA7
APP
AR
ARL15
ATN1
ATXN1
BID
BPGM
BTBD2
CAMK1
CAMK2B
CAMK4
CDKN1A
CDKN2A
CEBPA
CHP1
DUX4
DYNLL1
EGFR
ERBB2
FBXO7
FKBP6
FOXP1
GADD45A
GAS7
GOT2
GRIA2
GRM1
HES1
HNF4G
HSPB2
HTT
ITGB5
KARS1
KAT5
KCNE3
LAMA4
LAMTOR5
LIG4
LINC01554
MAPK1
MTNR1A
MYOC
NFYC
NR1H4
NUFIP2
OGT
OSMR
OSTF1
PAFAH1B3
PCDHA4
PCNA
PDIA2
PGK1
PLD2
POT1
POU2F2
PPM1E
PRDX1
PRKCI
PRPF40A
PSEN1
PSMD11
PTPRF
RAB2A
RBM5
RPA2
RXFP4
S100A6
SERPINB9
SHANK3
SIAH1
SIRT1
SLC2A1
SLC2A4
SMARCA2
SMN1
SUMO4
TERF1
TINF2
TK1
TPPP
TSC2
TXNIP
USP25
WEE2-AS1
YWHAE
YWHAQ
30 interacting genes:
CBX8
DDIT4
ECD
EEF1A1
FHL1
GAPDH
HDAC1
HDAC3
HSPB2
IDI1
INTS9
KPNA2
LUC7L3
MAPK1
NLGN3
PRKAA1
PTPN11
RUVBL2
SCEL
SIVA1
SLC2A1
SMURF2
TRAF6
TXN
TXNRD1
UBR5
UXT
WWP1
ZBTB16
ZBTB32
Entrez ID
2597
10628
HPRD ID
00713
05964
Ensembl ID
ENSG00000111640
ENSG00000265972
Uniprot IDs
P04406
V9HVZ4
Q9H3M7
PDB IDs
1U8F
1ZNQ
3GPD
4WNC
4WNI
6ADE
6IQ6
6M61
6YND
6YNE
6YNF
6YNH
8DNS
8G12
8G13
8G14
8G15
8G16
8G17
8P5F
4GEI
4GEJ
4GFX
4LL1
4LL4
4ROF
4ROJ
5CQ2
5DF6
5DWS
5DZD
Enriched GO Terms of Interacting Partners
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Developmental Process
Cellular Developmental Process
Nucleus
Cell Differentiation
Regulation Of Programmed Cell Death
Regulation Of Phosphorus Metabolic Process
Shelterin Complex
Regulation Of Cellular Component Organization
Negative Regulation Of Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of DNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Identical Protein Binding
Nuclear Telomere Cap Complex
Protein-containing Complex
Regulation Of Cellular Localization
Cellular Response To Stress
Regulation Of Cellular Response To Stress
Regulation Of Multicellular Organismal Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Protein Localization
Regulation Of DNA Metabolic Process
Telomeric DNA Binding
Telomere Capping
Regulation Of Phosphorylation
Nucleoplasm
Regulation Of Developmental Process
Negative Regulation Of DNA Biosynthetic Process
DNA Biosynthetic Process
Telomere Assembly
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle
Regulation Of Chromosome Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Phosphate Metabolic Process
Regulation Of Cell Population Proliferation
Negative Regulation Of Biosynthetic Process
Cytosol
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Signaling
Positive Regulation Of Chromosome Organization
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Development
Positive Regulation Of Cellular Component Organization
System Development
Nucleus
Cytosol
Cytoplasm
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Protein Lysine Delactylase Activity
Regulation Of Signal Transduction
Positive Regulation Of Type I Interferon Production
Negative Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Metabolic Process
Nucleoplasm
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Export From Nucleus
Regulation Of Protein Stability
Regulation Of Gene Expression
Positive Regulation Of Signal Transduction
Protein Modification Process
Regulation Of Cell Communication
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signaling
Regulation Of RNA Metabolic Process
Regulation Of Nucleocytoplasmic Transport
Thioredoxin-disulfide Reductase (NADPH) Activity
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Primary Metabolic Process
Regulation Of Type I Interferon Production
Histone Deacetylase Binding
Negative Regulation Of Protein Export From Nucleus
Transcription Corepressor Binding
Regulation Of Metabolic Process
Negative Regulation Of Signal Transduction
Regulation Of Macromolecule Metabolic Process
Regulation Of Intracellular Transport
Response To Epidermal Growth Factor
Regulation Of Intracellular Protein Transport
Histone Deacetylase Activity, Hydrolytic Mechanism
Bergmann Glial Cell Differentiation
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