GAPDH and PPM1E

Number of citations of the paper that reports this interaction (PubMedID 15680915)
0

Data Source:
HPRD (in vitro, in vivo)

		GAPDH	PPM1E
Description		glyceraldehyde-3-phosphate dehydrogenase	protein phosphatase, Mg2+/Mn2+ dependent 1E
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lipid Droplet Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome GAIT Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex
	Molecular Function	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding Microtubule Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Transferase Activity Aspartic-type Endopeptidase Inhibitor Activity Peptidyl-cysteine S-nitrosylase Activity Identical Protein Binding NADP Binding NAD Binding Disordered Domain Specific Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Positive Regulation Of Cytokine Production Immune System Process Glucose Metabolic Process Glycolytic Process Regulation Of Translation Apoptotic Process Negative Regulation Of Endopeptidase Activity Regulation Of Macroautophagy Negative Regulation Of Translation Killing Of Cells Of Another Organism Positive Regulation Of Type I Interferon Production Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Stabilization Defense Response To Fungus Neuron Apoptotic Process Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Type II Interferon	Negative Regulation Of Protein Kinase Activity Signal Transduction Peptidyl-threonine Dephosphorylation Positive Regulation Of Stress Fiber Assembly Cellular Response To Lipopolysaccharide Cellular Response To Xenobiotic Stimulus
Pathways		Glycolysis Gluconeogenesis	Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs		NADH Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Xanthinol Copper Artenimol
Diseases
GWAS		Blood protein levels ( 30072576)	Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive function ( 25644384) Cognitive test performance ( 17903297) Intelligence (MTAG) ( 29326435) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Systolic blood pressure ( 30224653 30578418) Testicular germ cell tumor ( 23666239)
Interacting Genes		92 interacting genes: ACD ACTB ACTC1 ANXA1 ANXA7 APP AR ARL15 ATN1 ATXN1 BID BPGM BTBD2 CAMK1 CAMK2B CAMK4 CDKN1A CDKN2A CEBPA CHP1 DUX4 DYNLL1 EGFR ERBB2 FBXO7 FKBP6 FOXP1 GADD45A GAS7 GOT2 GRIA2 GRM1 HES1 HNF4G HSPB2 HTT ITGB5 KARS1 KAT5 KCNE3 LAMA4 LAMTOR5 LIG4 LINC01554 MAPK1 MTNR1A MYOC NFYC NR1H4 NUFIP2 OGT OSMR OSTF1 PAFAH1B3 PCDHA4 PCNA PDIA2 PGK1 PLD2 POT1 POU2F2 PPM1E PRDX1 PRKCI PRPF40A PSEN1 PSMD11 PTPRF RAB2A RBM5 RPA2 RXFP4 S100A6 SERPINB9 SHANK3 SIAH1 SIRT1 SLC2A1 SLC2A4 SMARCA2 SMN1 SUMO4 TERF1 TINF2 TK1 TPPP TSC2 TXNIP USP25 WEE2-AS1 YWHAE YWHAQ	5 interacting genes: ARHGEF7 DISC1 GAPDH PRKAA1 TNIK
Entrez ID		2597	22843
HPRD ID		00713	17888
Ensembl ID		ENSG00000111640	ENSG00000175175
Uniprot IDs		P04406 V9HVZ4	Q8WY54
PDB IDs		1U8F 1ZNQ 3GPD 4WNC 4WNI 6ADE 6IQ6 6M61 6YND 6YNE 6YNF 6YNH 8DNS 8G12 8G13 8G14 8G15 8G16 8G17 8P5F
Enriched GO Terms of Interacting Partners?		Developmental Process Cellular Developmental Process Nucleus Cell Differentiation Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Shelterin Complex Regulation Of Cellular Component Organization Negative Regulation Of Metabolic Process Intracellular Signal Transduction Positive Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Nuclear Telomere Cap Complex Protein-containing Complex Regulation Of Cellular Localization Cellular Response To Stress Regulation Of Cellular Response To Stress Regulation Of Multicellular Organismal Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of DNA Metabolic Process Telomeric DNA Binding Telomere Capping Regulation Of Phosphorylation Nucleoplasm Regulation Of Developmental Process Negative Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomere Assembly Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Programmed Cell Death Positive Regulation Of Signaling Positive Regulation Of Chromosome Organization Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Development Positive Regulation Of Cellular Component Organization System Development	Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Response To Prostaglandin E Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Neuron Cellular Homeostasis Positive Regulation Of Intracellular Signal Transduction Organelle Organization Regulation Of Cellular Component Organization TOR Signaling Regulation Of Developmental Process Negative Regulation Of Glucosylceramide Biosynthetic Process Positive Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Microtubule Nucleation Positive Regulation Of Developmental Process Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Intracellular Chemical Homeostasis Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of JNK Cascade CCR7 Chemokine Receptor Binding CCL19-activated CCR7 Signaling Pathway Nervous System Development Glucose Metabolic Process Killing Of Cells Of Another Organism Regulation Of Protein Metabolic Process Positive Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Peptidyl-cysteine S-nitrosylase Activity Cold Acclimation Positive Regulation Of Mitochondrial Transcription Cellular Homeostasis Myeloid Dendritic Cell Chemotaxis Regulation Of Dendritic Cell Dendrite Assembly CCR10 Chemokine Receptor Binding Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Regulation Of JNK Cascade
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