GAPDH and PPM1E

Number of citations of the paper that reports this interaction (PMID 15680915)
3

Data Source:
HPRD (in vivo, in vitro)

		GAPDH	PPM1E
Gene Name		glyceraldehyde-3-phosphate dehydrogenase	protein phosphatase, Mg2+/Mn2+ dependent, 1E
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lipid Particle Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Ribonucleoprotein Complex Nuclear Membrane Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome GAIT Complex	Nucleus Nucleolus Mitochondrion Protein Complex
	Molecular Function	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding Microtubule Binding Peptidyl-cysteine S-nitrosylase Activity Identical Protein Binding NADP Binding NAD Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Pathogenesis Negative Regulation Of Translation Peptidyl-cysteine S-trans-nitrosylation Small Molecule Metabolic Process Protein Stabilization Neuron Apoptotic Process Oxidation-reduction Process Cellular Response To Interferon-gamma	Negative Regulation Of Protein Kinase Activity Cellular Response To Drug Peptidyl-threonine Dephosphorylation Positive Regulation Of Stress Fiber Assembly
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs		NADH Nicotinamide-Adenine-Dinucleotide Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
Diseases
GWAS			Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive test performance ( 17903297) Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		75 interactors: ACD ACTB ACTC1 ANXA1 ANXA7 APP AR ARL15 ATN1 ATXN1 BID BPGM BTBD2 CAMK1 CAMK2B CAMK4 CDKN1A CDKN2A CHP1 DYNLL1 EGFR FKBP6 GADD45A GAS7 GOT2 GRM1 GSK3B HES1 HNF4G HTT KARS KAT5 KCNE3 LAMA4 LAMTOR5 LIG4 MAPK1 MYOC NFYC NR1H4 OSMR OSTF1 PAFAH1B3 PCDHA4 PCNA PDIA2 PGK1 PLD2 POT1 POU2F2 PPM1E PRDX1 PRKCI PRPF40A PSEN1 PSMD11 RAB2A RBM5 RPA2 S100A6 SERPINB9 SIAH1 SIRT1 SLC2A1 SLC2A4 SMN1 SNCA SUMO4 TERF1 TINF2 TK1 TPPP USP25 YWHAE YWHAQ	4 interactors: ARHGEF7 DISC1 GAPDH TNIK
Entrez ID		2597	22843
HPRD ID		00713	17888
Ensembl ID		ENSG00000111640
Uniprot IDs		P04406	A7E2X1 Q8WY54
PDB IDs		1U8F 1ZNQ 2FEH 3GPD
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Cell Death Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death System Development Response To Stimulus Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Transport Regulation Of Cellular Response To Heat Regulation Of Cellular Component Organization Anatomical Structure Development Regulation Of Establishment Of Protein Localization Positive Regulation Of Apoptotic Process Multicellular Organismal Development Response To Abiotic Stimulus Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Localization Regulation Of Protein Localization Regulation Of Cellular Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Organelle Organization Neuron Apoptotic Process Cell Cycle Cellular Response To Stress Regulation Of Catalytic Activity Neuron Death Negative Regulation Of Protein Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Phosphorylation Cellular Response To Heat Negative Regulation Of Transferase Activity Regulation Of Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Homeostatic Process Positive Regulation Of Intracellular Transport Cell Differentiation Positive Regulation Of Metabolic Process Cellular Component Assembly Positive Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition	Regulation Of Cell Projection Organization Peptidyl-cysteine S-trans-nitrosylation Regulation Of Cell Development Cytoskeleton Organization Positive Regulation Of Lamellipodium Morphogenesis Peptidyl-cysteine S-nitrosylation Wnt Signaling Pathway Cell Projection Assembly Regulation Of Lamellipodium Morphogenesis Generation Of Neurons Regulation Of Cell Differentiation Neurogenesis Activation Of JNKK Activity Regulation Of Neuron Projection Development Positive Regulation Of Fibroblast Migration Intracellular Signal Transduction Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Morphogenesis Microvillus Assembly Positive Regulation Of Cell Development Microvillus Organization Mitochondrial Calcium Ion Homeostasis Regulation Of Protein Metabolic Process Positive Regulation Of Lamellipodium Organization Regulation Of Neuron Differentiation Regulation Of Synapse Maturation Nervous System Development TOR Signaling Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neurogenesis Focal Adhesion Assembly Regulation Of Fibroblast Migration Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Signal Transduction Microtubule-based Process Cellular Response To Stimulus Lamellipodium Assembly Positive Regulation Of Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Adherens Junction Assembly Regulation Of Signaling Lamellipodium Organization Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Cell Proliferation In Forebrain Organelle Organization
Tagcloud ?		apart caenorhabditis cloning cyst drive elegans ends flanking frame genetics globodera gluconeogenesis glyceraldehyde glycolysis gonads gpd green leader microinjected nematode nucleotides obligatory parasitic pathogenicity potato rostochiensis sl1 spliced	2c ac acetylated aging alters bipolar decarboxylase gad1 glutamic h3k9k14 hdac homolog htr2c hydroxytryptamine hypoacetylation lysines marks neuropsychiatric outer postmortem prefrontal psychiatric qpcr schizophrenia tomm70a transcriptionally translocase whereby
Tagcloud (Difference) ?		apart caenorhabditis cloning cyst drive elegans ends flanking frame genetics globodera gluconeogenesis glyceraldehyde glycolysis gonads gpd green leader microinjected nematode nucleotides obligatory parasitic pathogenicity potato rostochiensis sl1 spliced	2c ac acetylated aging alters bipolar decarboxylase gad1 glutamic h3k9k14 hdac homolog htr2c hydroxytryptamine hypoacetylation lysines marks neuropsychiatric outer postmortem prefrontal psychiatric qpcr schizophrenia tomm70a transcriptionally translocase whereby
Tagcloud (Intersection) ?