SMN1 and DMPK

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SMN1	DMPK
Description		survival of motor neuron 1, telomeric	DM1 protein kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Perikaryon Gemini Of Cajal Bodies	Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum Nuclear Membrane Mitochondrial Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Myosin Phosphatase Regulator Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly DNA-templated Transcription Termination MRNA Processing Nervous System Development RNA Splicing	Regulation Of Sodium Ion Transport Protein Phosphorylation Intracellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction Regulation Of Synapse Structural Plasticity
Pathways		snRNP Assembly SARS-CoV-2 modulates host translation machinery	Ion homeostasis
Drugs		Nusinersen	Bisindolylmaleimide VIII
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)	Myotonic dystrophy (DM)
GWAS			Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597)
Interacting Genes		166 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 ANXA2 APLP1 ARFGAP1 ATP5F1B ATP6V1A BAG6 BCL2 BLOC1S6 BYSL CARHSP1 CCDC90B CENPB CHTOP COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EEF1A2 EHHADH EIF3G EXT2 EZH2 FAM20C FAM9B FBL FGB FLAD1 FNDC11 FUBP1 FXR1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 H3-4 HADHB HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K IQUB ITCH JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAGED1 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NEURL2 NGFR NKIRAS2 NMT2 NRN1 NTAQ1 OSTF1 PDE4DIP PKM PLXNA3 POLR1C POLR2A POP7 PPIG PSME1 QARS1 RBBP4 RBBP6 RBFOX2 RBM48 REX1BD RN7SL1 RNU1-1 RNU11 RNU2-1 RNU4-1 RPL13 RPS2 RXRA SCARNA1 SDF4 SELENOW SEMA5B SETDB1 SMC5 SMN2 SNORA81 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNU13 SNUPN SP110 SPANXN2 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TERC TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 VPS28 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC	19 interacting genes: ANXA7 ATN1 ATXN1 CDC73 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4
Entrez ID		6606	1760
HPRD ID		02646	05645
Ensembl ID		ENSG00000172062	ENSG00000104936
Uniprot IDs		B4DP61 E7EQZ4 Q16637	B4DM55 B4DZE2 E5KR05 E5KR06 E5KR07 I6L989 Q09013
PDB IDs		1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 7W2P 7W30	1WT6 2VD5
Enriched GO Terms of Interacting Partners?		Spliceosomal SnRNP Assembly RNA Binding MRNA Metabolic Process RNA Splicing MRNA Processing RNA Splicing, Via Transesterification Reactions SMN-Sm Protein Complex RNA Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome RNA Metabolic Process U2-type Precatalytic Spliceosome Spliceosomal Complex Lsm2-8 Complex Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process U6 SnRNP Lsm1-7-Pat1 Complex Nucleoplasm Precatalytic Spliceosome SMN Complex U4 SnRNP Catalytic Step 2 Spliceosome Telomerase Holoenzyme Complex U7 SnRNP Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Small Nuclear Ribonucleoprotein Complex Nucleus Gemini Of Cajal Bodies Methylosome U12-type Spliceosomal Complex PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex Cytosol U2 SnRNP Spliceosomal Complex Assembly Protein-containing Complex Assembly U1 SnRNP U7 SnRNA Binding U5 SnRNP Cytoplasm Cajal Body Histone Pre-mRNA DCP Binding U2-type Prespliceosome Assembly Protein-containing Complex Organization U6 SnRNA Binding Promoter-specific Chromatin Binding	Regulation Of Cardiac Muscle Cell Membrane Potential G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Protein-containing Complex Organization SMN Complex Gemini Of Cajal Bodies SMN-Sm Protein Complex Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Motor Neuron Axon Guidance Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Developmental Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Rhombomere 3 Morphogenesis Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Cis-trans Isomerase Activity Cellular Component Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Protein Glutathionylation Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Insulin-like Growth Factor Receptor Signaling Pathway Spliceosomal SnRNP Assembly Response To Lipid Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Rhombomere 2 Development Positive Regulation Of Transcription By RNA Polymerase II Cytosol Enzyme Inhibitor Activity Focal Adhesion Regulation Of Biological Quality Positive Regulation Of Protein Phosphorylation Visual Behavior Regulation Of The Force Of Heart Contraction By Cardiac Conduction Visual Learning Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Susceptibility To T Cell Mediated Cytotoxicity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade
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