SMN1 and WIZ

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SMN1	WIZ
Gene Name		survival of motor neuron 1, telomeric	widely interspaced zinc finger motifs
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cajal Body Z Disc SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies	Nucleus Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Protein Binding Metal Ion Binding SET Domain Binding
	Biological Process	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly Nervous System Development Gene Expression NcRNA Metabolic Process	Positive Regulation Of Nuclear Cell Cycle DNA Replication Protein Stabilization Protein Heterotrimerization
Pathways		snRNP Assembly Metabolism of non-coding RNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		136 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 APLP1 ARFGAP1 ATP5B ATP6V1A BAG6 BCL2 C19orf60 CARHSP1 CCDC90B CENPB COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EIF3G EXT2 EZH2 FAM20C FBL FGB FLAD1 FUBP1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 HADHB HIST3H3 HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NGFR NKIRAS2 NMT2 OSTF1 PDE4DIP PKM PLXNA3 POLR2A POP7 PSME1 QARS RBBP4 RBBP6 RBFOX2 RBM48 RN7SL1 RNU1-1 RNU2-1 RPL13 RPS2 RXRA SDF4 SEMA5B SETDB1 SMC5 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNUPN SP110 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 WDR18 WDR73 WDYHV1 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC	14 interactors: C8orf33 CDKN1A EHMT1 EHMT2 OSGEP PIN1 RCC1 RPP14 RPS10 SMN1 SUV39H1 SUV39H2 TK1 TSC22D1
Entrez ID		6606	58525
HPRD ID		02646	11686
Ensembl ID		ENSG00000172062	ENSG00000011451
Uniprot IDs		B4DP61 Q16637	B3KVH1 M0QXA7 O95785
PDB IDs		1G5V 1MHN 2LEH 3S6N 4A4E 4A4G 4GLI
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Macromolecular Complex Assembly Histone MRNA Metabolic Process Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Process Nuclear-transcribed MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly MRNA Catabolic Process RNA Catabolic Process CRD-mediated MRNA Stabilization Regulation Of Protein Metabolic Process Termination Of RNA Polymerase II Transcription Regulation Of Cellular Protein Metabolic Process DNA-templated Transcription, Termination RNA Biosynthetic Process MRNA 3'-end Processing Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Transcription, DNA-templated RNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Spliceosomal Complex Assembly Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Developmental Process Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Cell Differentiation Catabolic Process	Peptidyl-lysine Dimethylation Histone H3-K9 Methylation Histone H3-K9 Modification Histone Lysine Methylation Peptidyl-lysine Methylation Histone Methylation Protein Methylation Histone H3-K9 Dimethylation Peptidyl-lysine Modification Histone H3-K9 Trimethylation Histone H3-K27 Methylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Cycle Histone Modification Negative Regulation Of Circadian Rhythm Methylation Nitrogen Compound Metabolic Process Peptidyl-lysine Trimethylation Peptidyl-amino Acid Modification NcRNA Metabolic Process Regulation Of Gene Expression, Epigenetic Chromatin Modification Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Chromatin Organization DNA Methylation Fetal Process Involved In Parturition Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process DNA Modification Threonylcarbamoyladenosine Biosynthetic Process Skeletal Muscle Cell Proliferation Regulation Of Circadian Rhythm Regulation Of Mitotic Cell Cycle Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Chromosome Organization Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Process DNA Methylation On Cytosine Within A CG Sequence Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Digestive Tract Development Threonylcarbamoyladenosine Metabolic Process
Tagcloud ?		atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness	ankyrin asd autism autistic ba21 ba40 boundaries brodmann delays dimethylation dorn ehmt1 ehmt2 g9a glp h3k9 heteromeric intellectual kleefstra lys968arg methyltransferases nonsynonymous novelty postmortem prioritized raphe restrictive surmise thr961ile
Tagcloud (Difference) ?		atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness	ankyrin asd autism autistic ba21 ba40 boundaries brodmann delays dimethylation dorn ehmt1 ehmt2 g9a glp h3k9 heteromeric intellectual kleefstra lys968arg methyltransferases nonsynonymous novelty postmortem prioritized raphe restrictive surmise thr961ile
Tagcloud (Intersection) ?