GAPDH and CAMK4

Number of citations of the paper that reports this interaction (PMID 15680915)
3

Data Source:
HPRD (in vitro)

		GAPDH	CAMK4
Gene Name		glyceraldehyde-3-phosphate dehydrogenase	calcium/calmodulin-dependent protein kinase IV
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lipid Particle Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Ribonucleoprotein Complex Nuclear Membrane Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome GAIT Complex	Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding Microtubule Binding Peptidyl-cysteine S-nitrosylase Activity Identical Protein Binding NADP Binding NAD Binding	Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding
	Biological Process	Microtubule Cytoskeleton Organization Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Pathogenesis Negative Regulation Of Translation Peptidyl-cysteine S-trans-nitrosylation Small Molecule Metabolic Process Protein Stabilization Neuron Apoptotic Process Oxidation-reduction Process Cellular Response To Interferon-gamma	Myeloid Dendritic Cell Cytokine Production Protein Phosphorylation Nucleocytoplasmic Transport Inflammatory Response Organelle Organization Mitochondrion Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Neuron-neuron Synaptic Transmission Long-term Memory Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of T Cell Differentiation In Thymus Myeloid Dendritic Cell Differentiation Innate Immune Response Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Export From Nucleus Neurotrophin TRK Receptor Signaling Pathway
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates	Signaling by GPCR Ca-dependent events CaM pathway Organelle biogenesis and maintenance Signaling by FGFR in disease Phospholipase C-mediated cascade Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR Activation of NMDA receptor upon glutamate binding and postsynaptic events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Post NMDA receptor activation events Innate Immune System Signaling by PDGF Calmodulin induced events Signalling by NGF CaMK IV-mediated phosphorylation of CREB DAP12 interactions PLC beta mediated events Opioid Signalling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma Mitochondrial biogenesis Signaling by ERBB2 CaMK IV-mediated phosphorylation of CREB Signaling by EGFR Activation of CaMK IV CREB phosphorylation through the activation of CaMKK Downstream signal transduction Calmodulin induced events PLC-gamma1 signalling Signaling by EGFR in Cancer Transcriptional activation of mitochondrial biogenesis Transmission across Chemical Synapses
Drugs		NADH Nicotinamide-Adenine-Dinucleotide Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Blood pressure ( 17903302)
Protein-Protein Interactions		75 interactors: ACD ACTB ACTC1 ANXA1 ANXA7 APP AR ARL15 ATN1 ATXN1 BID BPGM BTBD2 CAMK1 CAMK2B CAMK4 CDKN1A CDKN2A CHP1 DYNLL1 EGFR FKBP6 GADD45A GAS7 GOT2 GRM1 GSK3B HES1 HNF4G HTT KARS KAT5 KCNE3 LAMA4 LAMTOR5 LIG4 MAPK1 MYOC NFYC NR1H4 OSMR OSTF1 PAFAH1B3 PCDHA4 PCNA PDIA2 PGK1 PLD2 POT1 POU2F2 PPM1E PRDX1 PRKCI PRPF40A PSEN1 PSMD11 RAB2A RBM5 RPA2 S100A6 SERPINB9 SIAH1 SIRT1 SLC2A1 SLC2A4 SMN1 SNCA SUMO4 TERF1 TINF2 TK1 TPPP USP25 YWHAE YWHAQ	10 interactors: CABIN1 CAMKK1 CAMKK2 CREBBP GAPDH HDAC4 NEDD4 NOS1 NOTCH1 RELA
Entrez ID		2597	814
HPRD ID		00713	07169
Ensembl ID		ENSG00000111640
Uniprot IDs		P04406	Q16566
PDB IDs		1U8F 1ZNQ 2FEH 3GPD	2W4O
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Cell Death Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death System Development Response To Stimulus Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Transport Regulation Of Cellular Response To Heat Regulation Of Cellular Component Organization Anatomical Structure Development Regulation Of Establishment Of Protein Localization Positive Regulation Of Apoptotic Process Multicellular Organismal Development Response To Abiotic Stimulus Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Localization Regulation Of Protein Localization Regulation Of Cellular Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Organelle Organization Neuron Apoptotic Process Cell Cycle Cellular Response To Stress Regulation Of Catalytic Activity Neuron Death Negative Regulation Of Protein Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Phosphorylation Cellular Response To Heat Negative Regulation Of Transferase Activity Regulation Of Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Homeostatic Process Positive Regulation Of Intracellular Transport Cell Differentiation Positive Regulation Of Metabolic Process Cellular Component Assembly Positive Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition	Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Peptidyl-cysteine S-nitrosylation Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Protein Metabolic Process Response To Muramyl Dipeptide Signaling Peptidyl-amino Acid Modification Cell Communication Second-messenger-mediated Signaling Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Cellular Response To Stimulus Immune System Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Glial Cell Differentiation Response To Stress Defense Response Endocardial Cushion Development Response To Cytokine Negative Regulation Of Muscle Cell Differentiation Signal Transduction Negative Regulation Of Osteoblast Differentiation Response To Organic Substance Positive Regulation Of Gliogenesis Response To Hypoxia Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Regulation Of Myotube Differentiation Regulation Of Cell Development
Tagcloud ?		apart caenorhabditis cloning cyst drive elegans ends flanking frame genetics globodera gluconeogenesis glyceraldehyde glycolysis gonads gpd green leader microinjected nematode nucleotides obligatory parasitic pathogenicity potato rostochiensis sl1 spliced	7r believed cd27 cd28 cd8 cxcr1 cytolytic cytotoxic dapk1 differentiated effector exerted explained highlighted homeostasis il inf produce producers producing productivity proliferative promoted similarly spry2 subset subsets substantial terminally
Tagcloud (Difference) ?		apart caenorhabditis cloning cyst drive elegans ends flanking frame genetics globodera gluconeogenesis glyceraldehyde glycolysis gonads gpd green leader microinjected nematode nucleotides obligatory parasitic pathogenicity potato rostochiensis sl1 spliced	7r believed cd27 cd28 cd8 cxcr1 cytolytic cytotoxic dapk1 differentiated effector exerted explained highlighted homeostasis il inf produce producers producing productivity proliferative promoted similarly spry2 subset subsets substantial terminally
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