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SMN1 and LSM10
Number of citations of the paper that reports this interaction (PubMedID
16087681
)
0
Data Source:
BioGRID
(pull down, affinity chromatography technology)
SMN1
LSM10
Description
survival of motor neuron 1, telomeric
LSM10, U7 small nuclear RNA associated
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cajal Body
Nuclear Body
Z Disc
Axon
SMN Complex
SMN-Sm Protein Complex
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Neuron Projection
Perikaryon
Gemini Of Cajal Bodies
Nucleus
Nucleoplasm
U7 SnRNP
Cajal Body
Nuclear Body
Cytoplasmic U SnRNP Body
Ribonucleoprotein Complex
Molecular Function
RNA Binding
Protein Binding
Identical Protein Binding
RNA Binding
Protein Binding
Histone Pre-mRNA DCP Binding
U7 SnRNA Binding
Biological Process
Spliceosomal Complex Assembly
RNA Splicing, Via Transesterification Reactions
Spliceosomal SnRNP Assembly
DNA-templated Transcription Termination
MRNA Processing
Nervous System Development
RNA Splicing
MRNA Processing
MRNA 3'-end Processing By Stem-loop Binding And Cleavage
RNA Splicing
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
snRNP Assembly
SARS-CoV-2 modulates host translation machinery
SLBP independent Processing of Histone Pre-mRNAs
RNA Polymerase II Transcription Termination
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Drugs
Nusinersen
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Diverticulitis (
28585551
)
Neutrophil count (
29403010
)
Interacting Genes
166 interacting genes:
A1BG
A2M
ACTB
ACTL6B
ADAMTS10
AGAP1
ANXA2
APLP1
ARFGAP1
ATP5F1B
ATP6V1A
BAG6
BCL2
BLOC1S6
BYSL
CARHSP1
CCDC90B
CENPB
CHTOP
COIL
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CSAD
DDAH2
DDX20
DHX9
DMPK
DOCK7
DUS2
DYNC1I1
EEF1A1
EEF1A2
EHHADH
EIF3G
EXT2
EZH2
FAM20C
FAM9B
FBL
FGB
FLAD1
FNDC11
FUBP1
FXR1
GAPDH
GAR1
GDF9
GEMIN2
GEMIN5
GEMIN7
H3-4
HADHB
HMGXB3
HNRNPR
HNRNPU
HNRNPUL1
IGHM
ILF3
IMMT
INPP5K
IQUB
ITCH
JADE1
KDM1A
KIF5A
KLHL5
KMT2B
KPNB1
KRTAP19-6
KRTAP19-7
KRTAP21-2
KRTAP6-1
KRTAP6-2
LENG8
LRIF1
LSM1
LSM10
LSM11
LSM2
LSM3
LSM4
LSM5
LSM6
LSM7
MAGED1
MAST2
MED31
MKI67
MPP1
MRPL37
MSH2
NEURL2
NGFR
NKIRAS2
NMT2
NRN1
NTAQ1
OSTF1
PDE4DIP
PKM
PLXNA3
POLR1C
POLR2A
POP7
PPIG
PSME1
QARS1
RBBP4
RBBP6
RBFOX2
RBM48
REX1BD
RN7SL1
RNU1-1
RNU11
RNU2-1
RNU4-1
RPL13
RPS2
RXRA
SCARNA1
SDF4
SELENOW
SEMA5B
SETDB1
SMC5
SMN2
SNORA81
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNU13
SNUPN
SP110
SPANXN2
STRAP
STXBP2
STXBP3
SULT1A3
SUMO3
SYNCRIP
TAF1C
TERC
TIAL1
TLE1
TMSB4X
TP53
TRMT2A
TUBA1A
TUBB3
UCHL1
UNC119
USP4
VPS28
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZRANB2
ZXDC
10 interacting genes:
BMPR2
CLNS1A
LSM11
LSM3
MIR10B
MIR128-1
MIR20A
MIRLET7A1
SLBP
SMN1
Entrez ID
6606
84967
HPRD ID
02646
14326
Ensembl ID
ENSG00000172062
ENSG00000181817
Uniprot IDs
B4DP61
E7EQZ4
Q16637
Q969L4
PDB IDs
1G5V
1MHN
2LEH
4A4E
4A4G
4GLI
4QQ6
5XJL
5XJQ
5XJR
5XJS
5XJT
5XJU
7W2P
7W30
6V4X
Enriched GO Terms of Interacting Partners
?
Spliceosomal SnRNP Assembly
RNA Binding
MRNA Metabolic Process
RNA Splicing
MRNA Processing
RNA Splicing, Via Transesterification Reactions
SMN-Sm Protein Complex
RNA Processing
Ribonucleoprotein Complex
U4/U6 X U5 Tri-snRNP Complex
Protein-RNA Complex Assembly
MRNA Splicing, Via Spliceosome
RNA Metabolic Process
U2-type Precatalytic Spliceosome
Spliceosomal Complex
Lsm2-8 Complex
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
U6 SnRNP
Lsm1-7-Pat1 Complex
Nucleoplasm
Precatalytic Spliceosome
SMN Complex
U4 SnRNP
Catalytic Step 2 Spliceosome
Telomerase Holoenzyme Complex
U7 SnRNP
Macromolecule Metabolic Process
7-methylguanosine Cap Hypermethylation
Small Nuclear Ribonucleoprotein Complex
Nucleus
Gemini Of Cajal Bodies
Methylosome
U12-type Spliceosomal Complex
PICln-Sm Protein Complex
Spliceosomal Tri-snRNP Complex
Cytosol
U2 SnRNP
Spliceosomal Complex Assembly
Protein-containing Complex Assembly
U1 SnRNP
U7 SnRNA Binding
U5 SnRNP
Cytoplasm
Cajal Body
Histone Pre-mRNA DCP Binding
U2-type Prespliceosome Assembly
Protein-containing Complex Organization
U6 SnRNA Binding
Promoter-specific Chromatin Binding
MiRNA-mediated Gene Silencing By Inhibition Of Translation
MRNA Base-pairing Post-transcriptional Repressor Activity
RISC Complex
MiRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
Positive Regulation Of MRNA Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Regulatory NcRNA-mediated Gene Silencing
MRNA Processing
Negative Regulation Of Translation
Regulation Of Cell Migration Involved In Sprouting Angiogenesis
MRNA 3'-end Processing By Stem-loop Binding And Cleavage
Histone Pre-mRNA 3'end Processing Complex
MRNA Metabolic Process
MRNA Destabilization
RNA Destabilization
Regulation Of MRNA Metabolic Process
Positive Regulation Of MRNA Catabolic Process
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Cell Proliferation Involved In Heart Morphogenesis
MRNA 3'-UTR Binding
RNA Processing
Regulation Of Translation
Histone MRNA Metabolic Process
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Cell Migration
Regulation Of Cell Motility
MRNA 3'-end Processing
Regulation Of Endothelial Cell Migration
Regulation Of MRNA Stability
Regulation Of Locomotion
RNA Splicing, Via Transesterification Reactions
Regulation Of RNA Stability
Negative Regulation Of Protein Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Spliceosomal SnRNP Assembly
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Outflow Tract Morphogenesis
Negative Regulation Of Lipoprotein Transport
Negative Regulation Of Cardioblast Proliferation
RNA Metabolic Process
Negative Regulation Of Cell Migration
Negative Regulation Of Endothelial Cell Migration
Positive Regulation Of Osteoblast Differentiation
Extracellular Space
Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Motility
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