GAPDH and PSMD11

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GAPDH	PSMD11
Gene Name		glyceraldehyde-3-phosphate dehydrogenase	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lipid Particle Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Ribonucleoprotein Complex Nuclear Membrane Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome GAIT Complex	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle Membrane Proteasome Accessory Complex Extracellular Vesicular Exosome
	Molecular Function	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding Microtubule Binding Peptidyl-cysteine S-nitrosylase Activity Identical Protein Binding NADP Binding NAD Binding	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Pathogenesis Negative Regulation Of Translation Peptidyl-cysteine S-trans-nitrosylation Small Molecule Metabolic Process Protein Stabilization Neuron Apoptotic Process Oxidation-reduction Process Cellular Response To Interferon-gamma	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome Assembly Small Molecule Metabolic Process Stem Cell Differentiation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs		NADH Nicotinamide-Adenine-Dinucleotide Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
Diseases
GWAS
Protein-Protein Interactions		75 interactors: ACD ACTB ACTC1 ANXA1 ANXA7 APP AR ARL15 ATN1 ATXN1 BID BPGM BTBD2 CAMK1 CAMK2B CAMK4 CDKN1A CDKN2A CHP1 DYNLL1 EGFR FKBP6 GADD45A GAS7 GOT2 GRM1 GSK3B HES1 HNF4G HTT KARS KAT5 KCNE3 LAMA4 LAMTOR5 LIG4 MAPK1 MYOC NFYC NR1H4 OSMR OSTF1 PAFAH1B3 PCDHA4 PCNA PDIA2 PGK1 PLD2 POT1 POU2F2 PPM1E PRDX1 PRKCI PRPF40A PSEN1 PSMD11 RAB2A RBM5 RPA2 S100A6 SERPINB9 SIAH1 SIRT1 SLC2A1 SLC2A4 SMN1 SNCA SUMO4 TERF1 TINF2 TK1 TPPP USP25 YWHAE YWHAQ	33 interactors: APP BRD7 CCDC90B CCSER2 COPS6 CRMP1 EEF1A1 EEF1G GAPDH GDF9 HAP1 IGSF21 LRIF1 MED31 NFKB2 PRKAA1 PRMT6 PTN PTPRK RBM48 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 TLE1 TP53 TUBB2A UNC119 USP4 ZBTB16 ZHX1
Entrez ID		2597	5717
HPRD ID		00713	05119
Ensembl ID		ENSG00000111640	ENSG00000108671
Uniprot IDs		P04406	O00231
PDB IDs		1U8F 1ZNQ 2FEH 3GPD
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Cell Death Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death System Development Response To Stimulus Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Transport Regulation Of Cellular Response To Heat Regulation Of Cellular Component Organization Anatomical Structure Development Regulation Of Establishment Of Protein Localization Positive Regulation Of Apoptotic Process Multicellular Organismal Development Response To Abiotic Stimulus Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Localization Regulation Of Protein Localization Regulation Of Cellular Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Organelle Organization Neuron Apoptotic Process Cell Cycle Cellular Response To Stress Regulation Of Catalytic Activity Neuron Death Negative Regulation Of Protein Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Phosphorylation Cellular Response To Heat Negative Regulation Of Transferase Activity Regulation Of Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Homeostatic Process Positive Regulation Of Intracellular Transport Cell Differentiation Positive Regulation Of Metabolic Process Cellular Component Assembly Positive Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition	Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Cellular Response To Transforming Growth Factor Beta Stimulus RNA Biosynthetic Process RNA Metabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression SMAD Protein Complex Assembly Negative Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Pattern Specification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Response To Growth Factor Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mesonephros Development Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Primary MiRNA Processing Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Cell Proliferation Growth Positive Regulation Of Gene Expression Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Negative Regulation Of Transcription From RNA Polymerase II Promoter SMAD Protein Signal Transduction Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Developmental Growth
Tagcloud ?		apart caenorhabditis cloning cyst drive elegans ends flanking frame genetics globodera gluconeogenesis glyceraldehyde glycolysis gonads gpd green leader microinjected nematode nucleotides obligatory parasitic pathogenicity potato rostochiensis sl1 spliced
Tagcloud (Difference) ?		apart caenorhabditis cloning cyst drive elegans ends flanking frame genetics globodera gluconeogenesis glyceraldehyde glycolysis gonads gpd green leader microinjected nematode nucleotides obligatory parasitic pathogenicity potato rostochiensis sl1 spliced
Tagcloud (Intersection) ?