SMN1 and TERC

Number of citations of the paper that reports this interaction (PubMedID 30165668)
80

Data Source:
BioGRID (unspecified method)

		SMN1	TERC
Description		survival of motor neuron 1, telomeric	telomerase RNA component
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Perikaryon Gemini Of Cajal Bodies	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Telomerase Holoenzyme Complex Cytoplasm Cajal Body Box H/ACA Telomerase RNP Complex
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Template For Synthesis Of G-rich Strand Of Telomere DNA Activity Telomerase Activity RNA-directed DNA Polymerase Activity Protein Binding Protein-containing Complex Binding DNA Polymerase Binding WD40-repeat Domain Binding
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly DNA-templated Transcription Termination MRNA Processing Nervous System Development RNA Splicing	Telomere Maintenance Via Telomerase Cellular Response To Hypoxia Negative Regulation Of Cellular Senescence
Pathways		snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs		Nusinersen
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)	Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS			B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Bladder cancer ( 24163127) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 26237428) Glioma ( 28346443) Glioma (high-grade) ( 24908248) Leukocyte telomere length ( 32109421 31171785) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Multiple myeloma ( 23955597) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418) Telomere length ( 29151059 20139977 23900074 23535734 23001564 21573004) Thyroid cancer ( 28195142) Uterine fibroids ( 30194396 31649266)
Interacting Genes		166 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 ANXA2 APLP1 ARFGAP1 ATP5F1B ATP6V1A BAG6 BCL2 BLOC1S6 BYSL CARHSP1 CCDC90B CENPB CHTOP COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EEF1A2 EHHADH EIF3G EXT2 EZH2 FAM20C FAM9B FBL FGB FLAD1 FNDC11 FUBP1 FXR1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 H3-4 HADHB HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K IQUB ITCH JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAGED1 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NEURL2 NGFR NKIRAS2 NMT2 NRN1 NTAQ1 OSTF1 PDE4DIP PKM PLXNA3 POLR1C POLR2A POP7 PPIG PSME1 QARS1 RBBP4 RBBP6 RBFOX2 RBM48 REX1BD RN7SL1 RNU1-1 RNU11 RNU2-1 RNU4-1 RPL13 RPS2 RXRA SCARNA1 SDF4 SELENOW SEMA5B SETDB1 SMC5 SMN2 SNORA81 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNU13 SNUPN SP110 SPANXN2 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TERC TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 VPS28 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC	2 interacting genes: DKC1 SMN1
Entrez ID		6606	7012
HPRD ID		02646
Ensembl ID		ENSG00000172062	ENSG00000270141
Uniprot IDs		B4DP61 E7EQZ4 Q16637
PDB IDs		1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 7W2P 7W30
Enriched GO Terms of Interacting Partners?		Spliceosomal SnRNP Assembly RNA Binding MRNA Metabolic Process RNA Splicing MRNA Processing RNA Splicing, Via Transesterification Reactions SMN-Sm Protein Complex RNA Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome RNA Metabolic Process U2-type Precatalytic Spliceosome Spliceosomal Complex Lsm2-8 Complex Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process U6 SnRNP Lsm1-7-Pat1 Complex Nucleoplasm Precatalytic Spliceosome SMN Complex U4 SnRNP Catalytic Step 2 Spliceosome Telomerase Holoenzyme Complex U7 SnRNP Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Small Nuclear Ribonucleoprotein Complex Nucleus Gemini Of Cajal Bodies Methylosome U12-type Spliceosomal Complex PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex Cytosol U2 SnRNP Spliceosomal Complex Assembly Protein-containing Complex Assembly U1 SnRNP U7 SnRNA Binding U5 SnRNP Cytoplasm Cajal Body Histone Pre-mRNA DCP Binding U2-type Prespliceosome Assembly Protein-containing Complex Organization U6 SnRNA Binding Promoter-specific Chromatin Binding	Cajal Body Protein Localization To Cajal Body Box H/ACA Sno(s)RNA Metabolic Process Protein-RNA Complex Assembly Box H/ACA Sno(s)RNA 3'-end Processing Box H/ACA SnoRNA Binding Protein Localization To Nucleoplasm SnRNA Pseudouridine Synthesis Box H/ACA SnoRNP Complex Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA ScaRNP Complex Telomerase RNA Stabilization Box H/ACA Telomerase RNP Complex ScaRNA Localization To Cajal Body SnRNA Modification Telomerase Holoenzyme Complex Assembly Telomerase Activity RRNA Pseudouridine Synthesis Positive Regulation Of Telomerase RNA Localization To Cajal Body MRNA Pseudouridine Synthesis MRNA Metabolic Process Regulation Of Telomerase RNA Localization To Cajal Body Pseudouridine Synthase Activity SMN Complex Gemini Of Cajal Bodies Pseudouridine Synthesis Sno(s)RNA Metabolic Process SMN-Sm Protein Complex MRNA Modification DNA-templated Transcription Termination Telomerase RNA Binding Telomere Maintenance Via Telomerase Nucleobase-containing Compound Biosynthetic Process RNA Processing Telomerase Holoenzyme Complex Positive Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening RRNA Modification RNA Localization SnRNA Processing Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Protein-containing Complex Assembly Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly SnRNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening RNA Metabolic Process
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