STUB1 and CTNNB1

Number of citations of the paper that reports this interaction (PubMedID 29326975)
75

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		STUB1	CTNNB1
Description		STIP1 homology and U-box containing protein 1	catenin beta 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Z Disc Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Protein Folding Chaperone Complex	Euchromatin Spindle Pole Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Bicellular Tight Junction Focal Adhesion Cilium Cell Cortex Intercalated Disc Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Z Disc Lamellipodium Cell Junction Beta-catenin Destruction Complex Cell Projection Membrane Microvillus Membrane Protein-containing Complex Protein-DNA Complex Scrib-APC-beta-catenin Complex Ciliary Basal Body Presynaptic Membrane Cell Projection Apical Junction Complex Apical Part Of Cell Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Beta-catenin-TCF7L2 Complex Catenin-TCF7L2 Complex Cell Periphery RNA Polymerase II Transcription Regulator Complex Schaffer Collateral - CA1 Synapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse Postsynaptic Density, Intracellular Component Beta-catenin-ICAT Complex Beta-catenin-TCF Complex Wnt Signalosome
	Molecular Function	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Tau Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity R-SMAD Binding	Transcription Coregulator Binding Transcription Corepressor Binding Chromatin Binding Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Nuclear Receptor Binding Enzyme Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Protein Phosphatase Binding Nuclear Estrogen Receptor Binding Ubiquitin Protein Ligase Binding Transmembrane Transporter Binding Alpha-catenin Binding Cadherin Binding SMAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding I-SMAD Binding Disordered Domain Specific Binding DNA-binding Transcription Factor Binding Histone Methyltransferase Binding
	Biological Process	MAPK Cascade Protein Polyubiquitination Response To Ischemia DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins DNA Damage Response Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Protein Ubiquitination Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Glucocorticoid Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Heat Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway ERAD Pathway ERBB2 Signaling Pathway Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Protein Stabilization Protein Autoubiquitination Chaperone-mediated Autophagy Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Cellular Response To Hypoxia Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Mitophagy Positive Regulation Of ERAD Pathway Negative Regulation Of Vascular Associated Smooth Muscle Contraction	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Protein Polyubiquitination Embryonic Axis Specification Cell Morphogenesis Skeletal System Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Endoderm Formation Cell Fate Specification Endodermal Cell Fate Commitment Neuron Migration Kidney Development Epithelial To Mesenchymal Transition Neural Plate Development Tissue Homeostasis Vasculature Development Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Lens Morphogenesis In Camera-type Eye Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Metanephros Morphogenesis Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Adhesion Cell-matrix Adhesion Epidermal Growth Factor Receptor Signaling Pathway Chemical Synaptic Transmission Ectoderm Development Nervous System Development Glial Cell Fate Determination Neuroblast Proliferation Heart Development Intracellular Protein Localization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Xenobiotic Stimulus Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Mesenchymal Cell Proliferation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Layer Formation In Cerebral Cortex Hypothalamus Development Central Nervous System Vasculogenesis Hair Cycle Process Hemopoiesis Cell Differentiation Neuron Differentiation T Cell Differentiation Osteoclast Differentiation Lung Development Male Genitalia Development Epithelial Cell Differentiation Regulation Of Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Differentiation Forebrain Development Midbrain Development Hindbrain Development Regulation Of Centriole-centriole Cohesion Pancreas Development Hair Follicle Morphogenesis Regulation Of Protein Ubiquitination Regulation Of Myelination Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Transcription Elongation By RNA Polymerase II T Cell Differentiation In Thymus Negative Regulation Of Protein Sumoylation Positive Regulation Of Homotypic Cell-cell Adhesion Adherens Junction Organization Adherens Junction Assembly Protein Localization To Cell Surface Embryonic Heart Tube Development Genitalia Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Detection Of Muscle Stretch Embryonic Skeletal Limb Joint Morphogenesis Astrocyte-dopaminergic Neuron Signaling Regulation Of Cell Population Proliferation Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Cell-cell Adhesion Mediated By Cadherin Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Bone Resorption Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Fibroblast Proliferation Cell Maturation Synaptic Vesicle Transport Animal Organ Development Thymus Development Embryonic Organ Development Oocyte Development Embryonic Foregut Morphogenesis Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Determination Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Synapse Organization Detection Of Mechanical Stimulus Smooth Muscle Cell Differentiation Myoblast Proliferation Regulation Of Timing Of Anagen Regulation Of Synapse Assembly Oviduct Development Canonical Wnt Signaling Pathway Limb Development Mesenchymal To Epithelial Transition Trachea Morphogenesis Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Lung Cell Differentiation Lung-associated Mesenchyme Development Lung Epithelial Cell Differentiation Lung Induction Epithelial Cell Differentiation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Hair Follicle Placode Formation Establishment Of Blood-brain Barrier Mesenchymal Cell Proliferation Involved In Lung Development Positive Regulation Of Branching Involved In Lung Morphogenesis Endothelial Tube Morphogenesis Fungiform Papilla Formation Sympathetic Ganglion Development Cranial Ganglion Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Growth Factor Stimulus Cellular Response To Indole-3-methanol Renal Vesicle Formation Renal Inner Medulla Development Renal Outer Medulla Development Nephron Tubule Formation Stem Cell Proliferation Regulation Of Nephron Tubule Epithelial Cell Differentiation Mesenchymal Stem Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Calcium Ion Import Acinar Cell Differentiation Synaptic Vesicle Clustering Apoptotic Signaling Pathway Cell-cell Adhesion Positive Regulation Of Odontoblast Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cranial Skeletal System Development Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Blood Vessel Branching Neuron Projection Extension Embryonic Brain Development Dorsal Root Ganglion Development Establishment Of Blood-retinal Barrier Regulation Of Protein Localization To Cell Surface Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Myoblast Proliferation Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Downregulation of TGF-beta receptor signaling RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling Regulation of necroptotic cell death Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Myogenesis Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling Cardiogenesis Germ layer formation at gastrulation Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Formation of paraxial mesoderm Formation of axial mesoderm Formation of definitive endoderm Somitogenesis Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Formation of the nephric duct CDH11 homotypic and heterotypic interactions Specification of the neural plate border High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of PD-L1(CD274) transcription
Drugs			Urea
Diseases			Pilomatricoma; Epithelioma calcificans of Malherbe Gastric cancer Hepatocellular carcinoma Thyroid cancer Colorectal cancer Endometrial Cancer
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Bone mineral density (hip) ( 19801982 27311723) Bone mineral density (total hip) ( 29883787) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 22504420 29499414) Fractures ( 30158200) Heel bone mineral density ( 28869591 30598549) High myopia ( 31816047) Lumbar spine bone mineral density ( 29499414) Refractive error ( 32231278) Systolic blood pressure ( 30224653)
Interacting Genes		149 interacting genes: ABL1 ACD ADRM1 AHR AQP2 AR ATCAY ATXN3 BACE1 BAG1 BAG5 BBOX1 BCR BMPR1B CASP6 CCL28 CDK4 CDK9 CDKN1A CFTR CIP2A CRIP1 CTBP2 CTNNB1 CYP2E1 CYP3A4 DAPK1 DAXX DNAAF4 DNAJB1 E2F8 EGFR EIF5A ERBB2 ERG ERN1 ESR1 FADD FBXO2 FBXO27 FXR1 GHR GPR37 GUCY1A1 GUCY1A2 HMGB1 HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 HSPA9 HSPB1 HUNK INSR JAK1 JOSD1 JOSD2 KHDRBS1 KPNA2 LRRK1 MAP3K11 MAP3K2 MAP3K21 MAPK3 MAPT MCF2 METTL14 MFHAS1 MITF MPP1 MST1R MYOCD NOS1 NQO1 NR3C1 OLFM3 OTUD3 PA2G4 PFN1 PKM PLK1 PMAIP1 POLB POT1 PPP3CA PRKACA PRKCZ PRKN PRMT1 PSMA3 PSMC2 PSMD1 PSMD2 PSMD4 RAF1 RFFL RGS17 RHBDF2 RUNX1 RUNX2 RUSC1 S100A2 S100P SIRT6 SLC7A11-AS1 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SNCA SNPH SRC TAL1 TERF1 TGFBR1 TINF2 TP53 TP63 TP73 TPD52 TRAF6 TTN TXN2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2V2 UBE2W UNC45B VCP VDAC1 XIAP YTHDF2	205 interacting genes: ACP1 AJAP1 AKT1 AMER1 APC APC2 APP AR ARFGEF1 ARHGAP32 ASH2L AXIN1 AXIN2 BCL3 BCL6 BCL9 BCL9L BOC BRCA1 BTRC CA9 CARM1 CASP3 CASP8 CBL CBY1 CCAR1 CCDC88A CCND1 CDC27 CDC73 CDH1 CDH11 CDH15 CDH16 CDH2 CDH24 CDH3 CDH5 CDH7 CDH8 CDH9 CDK1 CDK2 CDK5R1 CDK6 CDON CEBPA CHD8 CHUK CREBBP CSNK1A1 CSNK1D CSNK2A1 CSNK2B CTNNA1 CTNNA3 CTNNBIP1 CTNND2 DLG5 DSC3 DVL1 DVL3 EGFR ELAVL1 EP300 ERBB2 ERBIN ESM1 ESR1 EZR FBXW2 FER FERMT2 FHIT FHL2 FLT1 FLT3 FOXO1 FOXO4 FSCN1 FUS FYN GLIS2 GNA13 GRIK2 GRIN1 GRIN2D GSK3B H1-2 HIF1A HNF1A HNF4A IGF2BP1 IKBKB IQGAP1 JADE1 KAT2A KAT2B KDR KMT2A KMT2D LATS2 LEF1 LEO1 MAGI1 MAGI2 MAP3K2 MAPK8 MAPK9 MEG3 MEN1 MET MITF MUC1 NAA10 NCOA2 NDRG1 NEK2 NEURL2 NF2 NFKB1 NHERF1 NOTCH1 NR5A1 NR5A2 PECAM1 PFKFB3 PICK1 PIK3R1 PIN1 PITX2 PKD1 PKM PKP2 PLK1 PPM1A PRKCG PSEN1 PSEN2 PTGS2 PTPN1 PTPN13 PTPN14 PTPN6 PTPRF PTPRJ PTPRK PTPRM PTPRU PTPRZ1 PYGO1 RAPGEF2 RBBP5 RIPK1 RUVBL1 RUVBL2 RXRA SALL1 SEC62 SHCBP1 SLC30A9 SMAD2 SMAD3 SMAD4 SMAD7 SMARCA4 SMARCA5 SMURF1 SOX1 SOX10 SOX17 SP1 SPN SRC STUB1 SYNE2 TAX1BP3 TBL1X TCF3 TCF4 TCF7L1 TCF7L2 TFAP2A TGFBR1 TGFBR2 TLE1 TRIM26 TRIM33 TRIM55 TRIM63 TRIP10 TRRAP TSC1 UBC UBE2B UBE2D1 UBE2R2 UBE3A UHRF2 USP10 USP13 USP9X ZFYVE9 ZIC3
Entrez ID		10273	1499
HPRD ID		06232	00286
Ensembl ID		ENSG00000103266	ENSG00000168036
Uniprot IDs		Q9UNE7	B4DGU4 P35222
PDB IDs		4KBQ 6EFK 6NSV 7TB1 8EHZ 8EI0 8F14 8F15 8F16 8F17 8FYU 8GCK 8SUV 9DRY	1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS 6M90 6M91 6M92 6M93 6M94 6O9B 6O9C 6WLX 6WNX 7AFW 7AR4 7UWI 7UWO 7ZRB 8EI9 8EIA 8EIB 8EIC 8RU3 8RU4 8VME 8VMF 8Y0G 8Y0P 8Y14 8Z0U 8Z10 8Z5J 8Z61
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Intracellular Signal Transduction Cytosol Regulation Of Primary Metabolic Process Enzyme Binding Positive Regulation Of Macromolecule Metabolic Process ATP Binding Nucleus Cytoplasm Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Protein Modification Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleotide Binding Regulation Of Intracellular Signal Transduction Protein-containing Complex Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Stress Cellular Response To Stress Proteasomal Protein Catabolic Process	Beta-catenin Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation Wnt Signaling Pathway Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Developmental Process Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Positive Regulation Of Signaling Positive Regulation Of Biosynthetic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Intracellular Signal Transduction Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Programmed Cell Death Cellular Developmental Process Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Anatomical Structure Morphogenesis Nucleoplasm Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway
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