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STUB1 and TINF2
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
STUB1
TINF2
Description
STIP1 homology and U-box containing protein 1
TERF1 interacting nuclear factor 2
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Z Disc
Ubiquitin Conjugating Enzyme Complex
Nuclear Inclusion Body
Protein Folding Chaperone Complex
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Chromosome
Perinucleolar Chromocenter
Nuclear Matrix
Nuclear Body
Shelterin Complex
Molecular Function
G Protein-coupled Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Enzyme Binding
Kinase Binding
Hsp70 Protein Binding
Protein-macromolecule Adaptor Activity
TPR Domain Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein Homodimerization Activity
SMAD Binding
Tau Protein Binding
Protein-folding Chaperone Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Ubiquitin Protein Ligase Activity
R-SMAD Binding
DNA Binding
Protein Binding
Telomeric DNA Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Response To Ischemia
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
DNA Damage Response
Signal Transduction
Positive Regulation Of Metabolic Process
Negative Regulation Of Cardiac Muscle Hypertrophy
Protein Ubiquitination
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Glucocorticoid Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Cellular Response To Heat
Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
ERAD Pathway
ERBB2 Signaling Pathway
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Protein Stabilization
Protein Autoubiquitination
Chaperone-mediated Autophagy
Protein K63-linked Ubiquitination
Cellular Response To Misfolded Protein
Cellular Response To Hypoxia
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Positive Regulation Of Mitophagy
Positive Regulation Of ERAD Pathway
Negative Regulation Of Vascular Associated Smooth Muscle Contraction
Telomere Capping
Telomere Assembly
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Epithelial Cell Proliferation
Protein Localization To Chromosome, Telomeric Region
Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways
Downregulation of TGF-beta receptor signaling
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
Regulation of RUNX2 expression and activity
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Leukocyte telomere length (
31171785
)
Platelet count (
29403010
)
Interacting Genes
149 interacting genes:
ABL1
ACD
ADRM1
AHR
AQP2
AR
ATCAY
ATXN3
BACE1
BAG1
BAG5
BBOX1
BCR
BMPR1B
CASP6
CCL28
CDK4
CDK9
CDKN1A
CFTR
CIP2A
CRIP1
CTBP2
CTNNB1
CYP2E1
CYP3A4
DAPK1
DAXX
DNAAF4
DNAJB1
E2F8
EGFR
EIF5A
ERBB2
ERG
ERN1
ESR1
FADD
FBXO2
FBXO27
FXR1
GHR
GPR37
GUCY1A1
GUCY1A2
HMGB1
HSF1
HSP90AA1
HSPA1A
HSPA1B
HSPA4
HSPA8
HSPA9
HSPB1
HUNK
INSR
JAK1
JOSD1
JOSD2
KHDRBS1
KPNA2
LRRK1
MAP3K11
MAP3K2
MAP3K21
MAPK3
MAPT
MCF2
METTL14
MFHAS1
MITF
MPP1
MST1R
MYOCD
NOS1
NQO1
NR3C1
OLFM3
OTUD3
PA2G4
PFN1
PKM
PLK1
PMAIP1
POLB
POT1
PPP3CA
PRKACA
PRKCZ
PRKN
PRMT1
PSMA3
PSMC2
PSMD1
PSMD2
PSMD4
RAF1
RFFL
RGS17
RHBDF2
RUNX1
RUNX2
RUSC1
S100A2
S100P
SIRT6
SLC7A11-AS1
SMAD1
SMAD2
SMAD3
SMAD4
SMG5
SMURF1
SNCA
SNPH
SRC
TAL1
TERF1
TGFBR1
TINF2
TP53
TP63
TP73
TPD52
TRAF6
TTN
TXN2
UBB
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2L3
UBE2N
UBE2Q1
UBE2V1
UBE2V2
UBE2W
UNC45B
VCP
VDAC1
XIAP
YTHDF2
91 interacting genes:
ACD
ACOT7
ACTB
ADA
AFAP1L2
AIPL1
AK1
ANKMY2
ANXA4
ANXA5
ANXA8L1
APOBEC3F
APPL2
ARHGDIA
ARID3B
BAG3
BIN2
CALD1
CCDC43
CCDC9
CKB
CLK3
CPNE3
CRYGS
CSNK2A1
CTTN
DBN1
DCX
DHFR2
DPP3
EEF1D
EIF4B
ENO2
FAM131B
FERMT3
FKBP6
GAPDH
GNMT
HNMT
HOXA3
HSP90AB1
IPO5
KCTD17
LASP1
LDHA
LGALSL
LTA4H
MAP2K3
MTNR1B
NCDN
NOL3
NUDC
NUDCD2
OR2H1
PAGE2
PAK1IP1
PEX5
PFKP
PGM1
PGM2
PHPT1
PKM
PPP1R2
PPP6R3
PRKCB
REM2
RGS14
RPSA
SARS1
SCRN2
SIAH2
STUB1
SULT1C2
TAGLN
TBL1X
TERF1
TERF2
TFRC
TOMM34
TPP1
TRIM15
TRIM16
TRIP10
TUBB
TUBB4B
TXNDC17
UCHL1
VIPR1
YWHAG
ZFP36L1
ZNF790
Entrez ID
10273
26277
HPRD ID
06232
16056
Ensembl ID
ENSG00000103266
ENSG00000092330
Uniprot IDs
Q9UNE7
B4DFJ1
Q9BSI4
PDB IDs
4KBQ
6EFK
6NSV
7TB1
8EHZ
8EI0
8F14
8F15
8F16
8F17
8FYU
8GCK
8SUV
9DRY
3BQO
3BU8
5XYF
Enriched GO Terms of Interacting Partners
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Ubiquitin Protein Ligase Binding
Positive Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Macromolecule Metabolic Process
Ubiquitin Conjugating Enzyme Activity
Intracellular Signal Transduction
Cytosol
Regulation Of Primary Metabolic Process
Enzyme Binding
Positive Regulation Of Macromolecule Metabolic Process
ATP Binding
Nucleus
Cytoplasm
Regulation Of Programmed Cell Death
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Catabolic Process
Protein Modification Process
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Nucleotide Binding
Regulation Of Intracellular Signal Transduction
Protein-containing Complex
Protein Polyubiquitination
Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
Regulation Of Post-translational Protein Modification
Positive Regulation Of Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Post-translational Protein Modification
Regulation Of Protein Modification Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Response To Stress
Cellular Response To Stress
Proteasomal Protein Catabolic Process
Cytosol
Extracellular Exosome
Cytoplasm
ADP Metabolic Process
Purine Ribonucleotide Catabolic Process
Ribonucleoside Diphosphate Metabolic Process
Glycolytic Process
ADP Catabolic Process
Purine Nucleotide Catabolic Process
Nucleoside Phosphate Catabolic Process
Nucleoside Diphosphate Metabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Ribonucleoside Diphosphate Catabolic Process
Nucleoside Diphosphate Catabolic Process
Cadherin Binding
Pyruvate Metabolic Process
Nucleotide Catabolic Process
Carbohydrate Catabolic Process
Shelterin Complex
Organophosphate Catabolic Process
Glucose Metabolic Process
RNA-templated DNA Biosynthetic Process
Nuclear Telomere Cap Complex
Glucose Catabolic Process
Nucleobase-containing Compound Catabolic Process
Protein Localization To Chromosome, Telomeric Region
ATP Metabolic Process
Hexose Metabolic Process
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Telomere Capping
Nicotinamide Nucleotide Metabolic Process
Purine-containing Compound Metabolic Process
Generation Of Precursor Metabolites And Energy
Ficolin-1-rich Granule Lumen
Nucleobase-containing Small Molecule Metabolic Process
Monosaccharide Metabolic Process
Carbohydrate Derivative Catabolic Process
Phosphoglucomutase Activity
Nucleoside Metabolic Process
Protein Binding
Purine Ribonucleotide Metabolic Process
Calcium-dependent Phospholipid Binding
Cellular Response To Heat
Canonical Glycolysis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Ribonucleotide Metabolic Process
Glycolytic Process Through Glucose-6-phosphate
Glycolytic Process Through Fructose-6-phosphate
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