Wiki-Pi
About
Search
People
Updates
Search
STUB1 and GHR
Number of citations of the paper that reports this interaction (PubMedID
22433856
)
60
Data Source:
BioGRID
(affinity chromatography technology, pull down)
STUB1
GHR
Description
STIP1 homology and U-box containing protein 1
growth hormone receptor
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Z Disc
Ubiquitin Conjugating Enzyme Complex
Nuclear Inclusion Body
Protein Folding Chaperone Complex
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Cytoplasmic Ribonucleoprotein Granule
Neuronal Cell Body
Receptor Complex
Growth Hormone Receptor Complex
Molecular Function
G Protein-coupled Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Enzyme Binding
Kinase Binding
Hsp70 Protein Binding
Protein-macromolecule Adaptor Activity
TPR Domain Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein Homodimerization Activity
SMAD Binding
Tau Protein Binding
Protein-folding Chaperone Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Ubiquitin Protein Ligase Activity
R-SMAD Binding
Cytokine Receptor Activity
Growth Hormone Receptor Activity
Protein Binding
Lipid Binding
Peptide Hormone Binding
Growth Factor Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cytokine Binding
Protein Tyrosine Kinase Activator Activity
SH2 Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
Proline-rich Region Binding
Protein Tyrosine Kinase Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Response To Ischemia
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
DNA Damage Response
Signal Transduction
Positive Regulation Of Metabolic Process
Negative Regulation Of Cardiac Muscle Hypertrophy
Protein Ubiquitination
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Glucocorticoid Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Cellular Response To Heat
Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
ERAD Pathway
ERBB2 Signaling Pathway
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Protein Stabilization
Protein Autoubiquitination
Chaperone-mediated Autophagy
Protein K63-linked Ubiquitination
Cellular Response To Misfolded Protein
Cellular Response To Hypoxia
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Positive Regulation Of Mitophagy
Positive Regulation Of ERAD Pathway
Negative Regulation Of Vascular Associated Smooth Muscle Contraction
Endocytosis
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Population Proliferation
Response To Gravity
Response To Hormone
Hormone-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Receptor Internalization
Response To Food
Regulation Of Response To Nutrient Levels
Response To Estradiol
Cellular Response To Insulin Stimulus
Cellular Response To Hormone Stimulus
Response To Cytokine
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Hormone Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of MAPK Cascade
Response To Peptide Hormone
Positive Regulation Of Cell Differentiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cycloheximide
Insulin-like Growth Factor Receptor Signaling Pathway
Response To Glucocorticoid
Cartilage Development Involved In Endochondral Bone Morphogenesis
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Response To Growth Hormone
Response To Interleukin-1
Pathways
Downregulation of TGF-beta receptor signaling
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
Regulation of RUNX2 expression and activity
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Prolactin receptor signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Somatotropin
Pegvisomant
Somatrem
Somapacitan
Lonapegsomatropin
Diseases
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Appendicular lean mass (
33097823
)
Blood protein levels (
30072576
)
Familial squamous cell lung carcinoma (
29924316
)
Heel bone mineral density (
30598549
)
Height (
25429064
28552196
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Iron status biomarkers (
19084217
)
Menarche (age at onset) (
25231870
)
Plasma renin activity levels (
29650764
)
Response to taxane treatment (docetaxel) (
23006423
)
Systemic lupus erythematosus (
18204098
)
Interacting Genes
149 interacting genes:
ABL1
ACD
ADRM1
AHR
AQP2
AR
ATCAY
ATXN3
BACE1
BAG1
BAG5
BBOX1
BCR
BMPR1B
CASP6
CCL28
CDK4
CDK9
CDKN1A
CFTR
CIP2A
CRIP1
CTBP2
CTNNB1
CYP2E1
CYP3A4
DAPK1
DAXX
DNAAF4
DNAJB1
E2F8
EGFR
EIF5A
ERBB2
ERG
ERN1
ESR1
FADD
FBXO2
FBXO27
FXR1
GHR
GPR37
GUCY1A1
GUCY1A2
HMGB1
HSF1
HSP90AA1
HSPA1A
HSPA1B
HSPA4
HSPA8
HSPA9
HSPB1
HUNK
INSR
JAK1
JOSD1
JOSD2
KHDRBS1
KPNA2
LRRK1
MAP3K11
MAP3K2
MAP3K21
MAPK3
MAPT
MCF2
METTL14
MFHAS1
MITF
MPP1
MST1R
MYOCD
NOS1
NQO1
NR3C1
OLFM3
OTUD3
PA2G4
PFN1
PKM
PLK1
PMAIP1
POLB
POT1
PPP3CA
PRKACA
PRKCZ
PRKN
PRMT1
PSMA3
PSMC2
PSMD1
PSMD2
PSMD4
RAF1
RFFL
RGS17
RHBDF2
RUNX1
RUNX2
RUSC1
S100A2
S100P
SIRT6
SLC7A11-AS1
SMAD1
SMAD2
SMAD3
SMAD4
SMG5
SMURF1
SNCA
SNPH
SRC
TAL1
TERF1
TGFBR1
TINF2
TP53
TP63
TP73
TPD52
TRAF6
TTN
TXN2
UBB
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2L3
UBE2N
UBE2Q1
UBE2V1
UBE2V2
UBE2W
UNC45B
VCP
VDAC1
XIAP
YTHDF2
44 interacting genes:
AP2A1
BTRC
CISH
CUL1
CUL5
DUSP7
ELOB
ELOC
FBXO31
GH1
GH2
GRB10
GRB2
IRS1
JAK1
JAK2
NCOA6
NEDD8
PIK3R1
PIK3R2
PLCG1
PTPN1
PTPN11
PTPN13
PTPN2
PTPN3
PTPN6
PTPN9
PTPRB
PTPRH
RBX1
RNF7
SGTA
SHC1
SKP1
SOCS1
SOCS2
SOCS3
SRPK2
STAT3
STAT5A
STAT5B
STUB1
TYK2
Entrez ID
10273
2690
HPRD ID
06232
02971
Ensembl ID
ENSG00000103266
ENSG00000112964
Uniprot IDs
Q9UNE7
A0A087X0H5
A0A087X162
P10912
PDB IDs
4KBQ
6EFK
6NSV
7TB1
8EHZ
8EI0
8F14
8F15
8F16
8F17
8FYU
8GCK
8SUV
9DRY
1A22
1AXI
1HWG
1HWH
1KF9
2AEW
3HHR
5OEK
5OHD
6I5J
6I5N
Enriched GO Terms of Interacting Partners
?
Ubiquitin Protein Ligase Binding
Positive Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Macromolecule Metabolic Process
Ubiquitin Conjugating Enzyme Activity
Intracellular Signal Transduction
Cytosol
Regulation Of Primary Metabolic Process
Enzyme Binding
Positive Regulation Of Macromolecule Metabolic Process
ATP Binding
Nucleus
Cytoplasm
Regulation Of Programmed Cell Death
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Catabolic Process
Protein Modification Process
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Nucleotide Binding
Regulation Of Intracellular Signal Transduction
Protein-containing Complex
Protein Polyubiquitination
Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
Regulation Of Post-translational Protein Modification
Positive Regulation Of Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Post-translational Protein Modification
Regulation Of Protein Modification Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Response To Stress
Cellular Response To Stress
Proteasomal Protein Catabolic Process
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Modification Process
Cytokine-mediated Signaling Pathway
Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Phosphotyrosine Residue Binding
Cell Surface Receptor Signaling Pathway Via STAT
Cytosol
Protein Dephosphorylation
Growth Hormone Receptor Binding
Protein Tyrosine Phosphatase Activity
Peptidyl-tyrosine Dephosphorylation
Signal Transduction
Protein Metabolic Process
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Insulin Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Macromolecule Metabolic Process
Cul5-RING Ubiquitin Ligase Complex
Dephosphorylation
Phosphoprotein Phosphatase Activity
Regulation Of Signal Transduction
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Cellular Response To Insulin Stimulus
Protein Ubiquitination
Insulin Receptor Binding
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Cellular Response To Insulin Stimulus
Regulation Of Growth Hormone Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Protein Modification By Small Protein Conjugation
Regulation Of Signaling
Regulation Of Cell Communication
Post-translational Protein Modification
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Regulation Of Cell Adhesion
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Cytoplasm
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?