STUB1 and NQO1

Number of citations of the paper that reports this interaction (PubMedID 29091030)
61

Data Source:
BioGRID (enzymatic study)

		STUB1	NQO1
Description		STIP1 homology and U-box containing protein 1	NAD(P)H quinone dehydrogenase 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Z Disc Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Protein Folding Chaperone Complex	Nucleus Cytoplasm Cytosol Synapse
	Molecular Function	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Tau Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity R-SMAD Binding	RNA Binding NAD(P)H Dehydrogenase (quinone) Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity Identical Protein Binding NADH Dehydrogenase (quinone) (non-electrogenic) Activity
	Biological Process	MAPK Cascade Protein Polyubiquitination Response To Ischemia DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins DNA Damage Response Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Protein Ubiquitination Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Glucocorticoid Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Heat Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway ERAD Pathway ERBB2 Signaling Pathway Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Protein Stabilization Protein Autoubiquitination Chaperone-mediated Autophagy Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Cellular Response To Hypoxia Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Mitophagy Positive Regulation Of ERAD Pathway Negative Regulation Of Vascular Associated Smooth Muscle Contraction	Protein Polyubiquitination Ubiquinone Metabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress Synaptic Transmission, Cholinergic Response To Toxic Substance Removal Of Superoxide Radicals Protein Catabolic Process Response To Lipopolysaccharide Cellular Response To Oxidative Stress Negative Regulation Of Protein Catabolic Process Vitamin E Metabolic Process Vitamin K Metabolic Process Innate Immune Response Cell Redox Homeostasis Response To Caloric Restriction Negative Regulation Of Ferroptosis
Pathways		Downregulation of TGF-beta receptor signaling RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling Regulation of necroptotic cell death Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Regulation of ornithine decarboxylase (ODC) NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs			Menadione Dicoumarol Duroquinone 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol ES-936 Cibacron Blue Flavin adenine dinucleotide 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione RH-1 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE Cannabidiol
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Alcohol consumption (drinks per week) ( 30679032) Blood osmolality (transformed sodium) ( 28360221) Blood protein levels ( 30072576) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Risk-taking tendency (4-domain principal component model) ( 30643258) Triglyceride levels ( 32203549)
Interacting Genes		149 interacting genes: ABL1 ACD ADRM1 AHR AQP2 AR ATCAY ATXN3 BACE1 BAG1 BAG5 BBOX1 BCR BMPR1B CASP6 CCL28 CDK4 CDK9 CDKN1A CFTR CIP2A CRIP1 CTBP2 CTNNB1 CYP2E1 CYP3A4 DAPK1 DAXX DNAAF4 DNAJB1 E2F8 EGFR EIF5A ERBB2 ERG ERN1 ESR1 FADD FBXO2 FBXO27 FXR1 GHR GPR37 GUCY1A1 GUCY1A2 HMGB1 HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 HSPA9 HSPB1 HUNK INSR JAK1 JOSD1 JOSD2 KHDRBS1 KPNA2 LRRK1 MAP3K11 MAP3K2 MAP3K21 MAPK3 MAPT MCF2 METTL14 MFHAS1 MITF MPP1 MST1R MYOCD NOS1 NQO1 NR3C1 OLFM3 OTUD3 PA2G4 PFN1 PKM PLK1 PMAIP1 POLB POT1 PPP3CA PRKACA PRKCZ PRKN PRMT1 PSMA3 PSMC2 PSMD1 PSMD2 PSMD4 RAF1 RFFL RGS17 RHBDF2 RUNX1 RUNX2 RUSC1 S100A2 S100P SIRT6 SLC7A11-AS1 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SNCA SNPH SRC TAL1 TERF1 TGFBR1 TINF2 TP53 TP63 TP73 TPD52 TRAF6 TTN TXN2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2V2 UBE2W UNC45B VCP VDAC1 XIAP YTHDF2	10 interacting genes: CDC42 DNAJB1 GALT HIF1A HSPA1A ING1 PRKN STUB1 TP53 UBE2D1
Entrez ID		10273	1728
HPRD ID		06232	00518
Ensembl ID		ENSG00000103266	ENSG00000181019
Uniprot IDs		Q9UNE7	B4DLR8 P15559
PDB IDs		4KBQ 6EFK 6NSV 7TB1 8EHZ 8EI0 8F14 8F15 8F16 8F17 8FYU 8GCK 8SUV 9DRY	1D4A 1DXO 1GG5 1H66 1H69 1KBO 1KBQ 1QBG 2F1O 3JSX 4CET 4CF6 5A4K 5EA2 5EAI 5FUQ 6FY4 6LLC 8C9J 8OK0 8PQN 8RFM 8RFN
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Intracellular Signal Transduction Cytosol Regulation Of Primary Metabolic Process Enzyme Binding Positive Regulation Of Macromolecule Metabolic Process ATP Binding Nucleus Cytoplasm Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Protein Modification Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleotide Binding Regulation Of Intracellular Signal Transduction Protein-containing Complex Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Stress Cellular Response To Stress Proteasomal Protein Catabolic Process	Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Post-translational Protein Modification Protein-folding Chaperone Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Topologically Incorrect Protein Ubiquitin Protein Ligase Binding Regulation Of Growth Histone Deacetylase Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Regulation Of Cell Growth Enzyme Binding Hsp70 Protein Binding Regulation Of Mitophagy Protein-containing Complex Cellular Response To Heat Regulation Of Autophagy Of Mitochondrion Regulation Of Protein-containing Complex Assembly Negative Regulation Of RNA Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Positive Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Heat Shock Protein Binding Negative Regulation Of Apoptotic Process Negative Regulation Of Growth Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Positive Regulation Of Response To Cytokine Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Biogenesis Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Protein Stabilization Regulation Of Programmed Cell Death Regulation Of Cellular Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Response To Heat
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