STUB1 and MITF

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		STUB1	MITF
Description		STIP1 homology and U-box containing protein 1	melanocyte inducing transcription factor
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Z Disc Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Protein Folding Chaperone Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Protein-containing Complex
	Molecular Function	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Tau Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity R-SMAD Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding
	Biological Process	MAPK Cascade Protein Polyubiquitination Response To Ischemia DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins DNA Damage Response Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Protein Ubiquitination Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Glucocorticoid Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Heat Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway ERAD Pathway ERBB2 Signaling Pathway Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Protein Stabilization Protein Autoubiquitination Chaperone-mediated Autophagy Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Cellular Response To Hypoxia Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Mitophagy Positive Regulation Of ERAD Pathway Negative Regulation Of Vascular Associated Smooth Muscle Contraction	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression Wnt Signaling Pathway Cell Differentiation Osteoclast Differentiation Melanocyte Differentiation Negative Regulation Of Cell Migration Regulation Of Cell Population Proliferation Camera-type Eye Development Negative Regulation Of Apoptotic Process Pigmentation Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Protein-containing Complex Assembly Melanocyte Apoptotic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of RNA Biosynthetic Process
Pathways		Downregulation of TGF-beta receptor signaling RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling Regulation of necroptotic cell death Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	SUMOylation of transcription factors Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases			Malignant melanoma Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Waardenburg syndrome (WS)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Apolipoprotein B levels ( 32203549) Blond vs. brown/black hair color ( 30531825) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Myocardial infarction ( 33532862) Neutrophil count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878) QRS complex (12-leadsum) ( 27659466) Red blood cell count ( 32888494 27863252) Renal underexcretion gout ( 32238385) Severe influenza A (H1N1) infection ( 26379185) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Waist-hip index ( 34021172)
Interacting Genes		149 interacting genes: ABL1 ACD ADRM1 AHR AQP2 AR ATCAY ATXN3 BACE1 BAG1 BAG5 BBOX1 BCR BMPR1B CASP6 CCL28 CDK4 CDK9 CDKN1A CFTR CIP2A CRIP1 CTBP2 CTNNB1 CYP2E1 CYP3A4 DAPK1 DAXX DNAAF4 DNAJB1 E2F8 EGFR EIF5A ERBB2 ERG ERN1 ESR1 FADD FBXO2 FBXO27 FXR1 GHR GPR37 GUCY1A1 GUCY1A2 HMGB1 HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 HSPA9 HSPB1 HUNK INSR JAK1 JOSD1 JOSD2 KHDRBS1 KPNA2 LRRK1 MAP3K11 MAP3K2 MAP3K21 MAPK3 MAPT MCF2 METTL14 MFHAS1 MITF MPP1 MST1R MYOCD NOS1 NQO1 NR3C1 OLFM3 OTUD3 PA2G4 PFN1 PKM PLK1 PMAIP1 POLB POT1 PPP3CA PRKACA PRKCZ PRKN PRMT1 PSMA3 PSMC2 PSMD1 PSMD2 PSMD4 RAF1 RFFL RGS17 RHBDF2 RUNX1 RUNX2 RUSC1 S100A2 S100P SIRT6 SLC7A11-AS1 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SNCA SNPH SRC TAL1 TERF1 TGFBR1 TINF2 TP53 TP63 TP73 TPD52 TRAF6 TTN TXN2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2V2 UBE2W UNC45B VCP VDAC1 XIAP YTHDF2	33 interacting genes: ADRB2 APP BTRC CLK4 CTNNB1 EBP EP300 FBXO7 FBXW11 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I
Entrez ID		10273	4286
HPRD ID		06232	01138
Ensembl ID		ENSG00000103266	ENSG00000187098
Uniprot IDs		Q9UNE7	A0A087WXU1 A0A8I5KSZ4 B4DNC7 O75030
PDB IDs		4KBQ 6EFK 6NSV 7TB1 8EHZ 8EI0 8F14 8F15 8F16 8F17 8FYU 8GCK 8SUV 9DRY	4C7N 7D8R 7D8S 7D8T 7EOD 8E1D
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Intracellular Signal Transduction Cytosol Regulation Of Primary Metabolic Process Enzyme Binding Positive Regulation Of Macromolecule Metabolic Process ATP Binding Nucleus Cytoplasm Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Protein Modification Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleotide Binding Regulation Of Intracellular Signal Transduction Protein-containing Complex Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Stress Cellular Response To Stress Proteasomal Protein Catabolic Process	Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Modification Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Negative Regulation Of RNA Metabolic Process Enzyme Binding Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction Post-translational Protein Modification Protein Sumoylation Cell Surface Receptor Signaling Pathway SUMO Transferase Activity Positive Regulation Of Cell Differentiation Chromatin Protein Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Hemopoiesis Positive Regulation Of Proteolysis Negative Regulation Of Intracellular Signal Transduction Regulation Of Myeloid Cell Differentiation Regulation Of Cell Communication Regulation Of Signaling Presynaptic Cytosol Postsynaptic Cytosol Chromatin Binding
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