STUB1 and CYP3A4

Number of citations of the paper that reports this interaction (PMID 22101235)
5

Data Source:
BioGRID (enzymatic study)

		STUB1	CYP3A4
Gene Name		STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	cytochrome P450, family 3, subfamily A, polypeptide 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	G-protein Coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein Binding, Bridging TPR Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity	Monooxygenase Activity Steroid Binding Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Enzyme Binding Heme Binding Vitamin D3 25-hydroxylase Activity Taurochenodeoxycholate 6alpha-hydroxylase Activity Caffeine Oxidase Activity Albendazole Monooxygenase Activity Quinine 3-monooxygenase Activity Testosterone 6-beta-hydroxylase Activity Vitamin D 24-hydroxylase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Misfolded Or Incompletely Synthesized Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Maturation Protein Autoubiquitination Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Positive Regulation Of Chaperone-mediated Protein Complex Assembly	Lipid Metabolic Process Steroid Catabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Androgen Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Small Molecule Metabolic Process Heterocycle Metabolic Process Oxidation-reduction Process Oxidative Demethylation
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by ERBB2 Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Aflatoxin activation and detoxification Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Xenobiotics Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations Defective ACY1 causes encephalopathy
Drugs
Diseases
GWAS			Metabolic traits ( 21886157)
Protein-Protein Interactions		92 interactors: ABL1 ACD AHR AR ATCAY ATXN3 BAG1 BAG5 BCR BMPR1B CCL28 CTBP2 CYP2E1 CYP3A4 DAXX DNAJB1 DYX1C1 EIF5A ERBB2 ERN1 ESR1 FBXO2 FBXO27 FOXP3 GHR GPR37 GUCY1A2 GUCY1A3 HIF1A HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 IRF1 JOSD1 JOSD2 KHDRBS1 KIAA1524 MAP3K11 MAP3K2 MAPT MCF2 MITF MPP1 MST1R MYOCD NOS1 NQO1 OLFM3 PARK2 PFN1 POLB POT1 PRKCZ PSMA3 PSMD4 RAF1 RUNX1 RUNX2 RUSC1 S100A2 S100P SIRT6 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SRC TAL1 TERF1 TGFBR1 TINF2 TRAF6 TXN2 UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2W VCP XIAP	9 interactors: AMFR CYB5A GK POR PRKACA PRKCA STUB1 UBC UGT2B7
Entrez ID		10273	1576
HPRD ID		06232	00484
Ensembl ID		ENSG00000103266
Uniprot IDs		Q9UNE7	P08684 Q6GRK0
PDB IDs			1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Cellular Response To Stimulus Protein Polyubiquitination Response To Stress Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Response To Stimulus Cellular Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Protein Modification Process Positive Regulation Of Gene Expression Cellular Response To Stress Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Catalytic Activity Regulation Of Cell Death Protein Ubiquitination Response To Growth Factor Regulation Of Cellular Component Organization Protein Modification By Small Protein Conjugation Cellular Protein Metabolic Process Regulation Of Cellular Process Cell Communication Positive Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Regulation Of Apoptotic Process Regulation Of Immune System Process Signaling Cell Death Death Cellular Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Death Negative Regulation Of Protein Metabolic Process Protein Metabolic Process	Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Cellular Response To Organic Substance Monosaccharide Metabolic Process Small Molecule Metabolic Process Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Organic Substance Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Catabolic Process Energy Reserve Metabolic Process Carbohydrate Metabolic Process Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Blood Vessel Endothelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Polyubiquitination Negative Regulation Of Adenylate Cyclase Activity Flavonoid Metabolic Process Negative Regulation Of Lyase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Rhodopsin Mediated Signaling Pathway Response To Growth Factor Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Neurotrophin TRK Receptor Signaling Pathway Regulation Of Platelet Activation Rhodopsin Mediated Signaling Pathway Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Neurotrophin Signaling Pathway Inactivation Of MAPK Activity Regulation Of Hormone Metabolic Process Regulation Of Proteolysis Mitotic Nuclear Envelope Disassembly Positive Regulation Of Adenylate Cyclase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		atg5 atg7 autophagic autophagosomes autophagy beclin chaperone degradation degraded delta133p53alpha downregulated e3 full identifies isoform knockdown ligase orchestrates passage proliferating replicative replicatively restores reveals senescence senescent sirna turnover unlike	amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cyp2c19 cyp2c9 cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin
Tagcloud (Difference) ?		atg5 atg7 autophagic autophagosomes autophagy beclin chaperone degradation degraded delta133p53alpha downregulated e3 full identifies isoform knockdown ligase orchestrates passage proliferating replicative replicatively restores reveals senescence senescent sirna turnover unlike	amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cyp2c19 cyp2c9 cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin
Tagcloud (Intersection) ?