CCT5 and ACTA1

Number of citations of the paper that reports this interaction (PMID 11580270)
13

Data Source:
HPRD (in vitro)

		CCT5	ACTA1
Gene Name		chaperonin containing TCP1, subunit 5 (epsilon)	actin, alpha 1, skeletal muscle
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Zona Pellucida Receptor Complex Nucleolus Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding ATP Binding G-protein Beta-subunit Binding Beta-tubulin Binding Unfolded Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Response To Virus Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development
Pathways		Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC	Striated Muscle Contraction
Drugs
Diseases
GWAS		Pain ( 22956598)
Protein-Protein Interactions		15 interactors: ACTA1 ACTA2 ACTB HDAC3 IKBKAP IMMT PDCL SSSCA1 SUMO4 TBC1D17 TCP1 TERT THEG TP53 XRN1	107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		22948	58
HPRD ID		06468	00030
Ensembl ID		ENSG00000150753	ENSG00000143632
Uniprot IDs		B4DYD8 B7ZAR1 E7ENZ3 E9PCA1 P48643	P68133 Q5T8M7
PDB IDs			1T44
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Protein Complex Assembly Replicative Senescence Chromatin Organization Chromosome Organization 'de Novo' Posttranslational Protein Folding Heterotrimeric G-protein Complex Assembly Negative Regulation Of Production Of SiRNA Involved In RNA Interference Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm 'de Novo' Protein Folding Protein Folding Cell Aging Negative Regulation Of Macromitophagy Negative Regulation Of RNA Interference Skeletal Muscle Fiber Adaptation Transcription, RNA-templated Oligodendrocyte Apoptotic Process Organelle Organization Negative Regulation Of Helicase Activity Telomere Formation Via Telomerase Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Negative Regulation Of Protein Refolding Notch Signaling Pathway Positive Regulation Of Thymocyte Apoptotic Process Glomerular Mesangial Cell Development Positive Regulation Of Cell Aging Skeletal Muscle Thin Filament Assembly Mitochondrial DNA Repair Mesangial Cell Development Telomere Assembly Nuclear MRNA Surveillance Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Renal Interstitial Fibroblast Development Glial Cell Apoptotic Process Circadian Rhythm Skeletal Myofibril Assembly Oxidative Stress-induced Premature Senescence RNA Surveillance	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly
Tagcloud ?		cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Difference) ?		cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Intersection) ?