CCT5 and ERCC6

Number of citations of the paper that reports this interaction (PubMedID 31722399)
57

Data Source:
BioGRID (pull down)

		CCT5	ERCC6
Description		chaperonin containing TCP1 subunit 5	ERCC excision repair 6, chromatin remodeling factor
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome	Nucleus Nucleoplasm Chromosome Nucleolus Transcription Elongation Factor Complex Nuclear Body Site Of DNA Damage B-WICH Complex
	Molecular Function	Nucleotide Binding MRNA 3'-UTR Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity G-protein Beta-subunit Binding Protein Folding Chaperone MRNA 5'-UTR Binding Beta-tubulin Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Nucleotide Binding DNA Binding DNA Helicase Activity Chromatin Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Protein Tyrosine Kinase Activator Activity Sequence-specific DNA Binding RNA Polymerase Binding Chromatin-protein Adaptor Activity ATP-dependent Chromatin Remodeler Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Response To Virus Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Single Strand Break Repair DNA Damage Checkpoint Signaling Response To Superoxide Positive Regulation Of Defense Response To Virus By Host DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Pyrimidine Dimer Repair Chromatin Remodeling Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II DNA Damage Response Response To Oxidative Stress JNK Cascade Nervous System Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Positive Regulation Of Gene Expression Protein Ubiquitination Neurogenesis Neuron Differentiation Neuron Projection Development Regulation Of DNA-templated Transcription Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Transcription Elongation By RNA Polymerase II Multicellular Organism Growth DNA Protection Photoreceptor Cell Maintenance Positive Regulation Of DNA Repair Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription Initiation By RNA Polymerase II Protein Localization To Chromatin Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Metabolite levels ( 23823483) Pain ( 22956598)	Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		23 interacting genes: ACTA1 ACTA2 ACTB CEBPA DCAF12 DUXAP9 ELP1 ERCC6 HDAC3 IMMT MCPH1 OGT PDCL SPMAP2 SUMO2 SUMO4 TBC1D17 TCP1 TERT TP53 VHL XRN1 ZNRD2	117 interacting genes: ACTR2 ACTR3 ARPC1A ATP5F1C ATP5PO CAVIN1 CCT5 CCT6A CHEK2 CLIC4 COPE CORO1C CSNK2A2 CSNK2B CTSB CUL5 DARS1 DCLRE1A ECHS1 EIF3C EIF3D EIF3F EIF3I EIF3L EIF4A3 ELOA ERCC5 ERCC8 FBLN2 FNDC3B FOSL1 FXR1 FYTTD1 GATAD2B GRPEL1 GTF2E2 GTF2I H2BC3 H3C1 H4C1 HDAC1 HDAC2 HNRNPUL2 HSPA5 HSPA9 HTATSF1 IARS2 IDH3G IWS1 LEO1 MBD3 MORC3 MRPL11 MRPL13 MRPL20 MRPL21 MRPL3 MRPL38 MRPL4 MRPL47 MRPL50 MRPL58 MRPS18B MRPS22 MRPS25 MRPS26 MTA1 MTA2 MTA3 NAP1L1 NONO NPLOC4 PAF1 PARP1 PCNA PFN2 PML POLR2A POLR2H PPIA PSMC5 RBBP7 RCC1 RHOG RNF11 RPL10 RPL13 RPL30 RPL39 RPL5 RPS15 RPS15A RPS24 RPS29 RPS6 SAE1 SDHA SENP2 SF3B3 SLC39A7 SNRPD1 SUMO1 SUMO2 SUPT6H TACO1 TP53 TPR UBA2 UBC UBE2I UQCRC1 UQCRQ USP7 XAB2 XPA XRCC5 ZBTB38
Entrez ID		22948	2074
HPRD ID		06468	00596
Ensembl ID		ENSG00000150753	ENSG00000225830
Uniprot IDs		B4DDU6 B4DX08 B4DYC8 B7ZAR1 E7ENZ3 E9PCA1 P48643 V9HW37	P0DP91 Q03468 Q59FF6
PDB IDs		5UYX 5UYZ 6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8AJM 8AJO 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT	4CVO 6A6I 7OO3 7OOB 7OOP 7OPC 7OPD 8B3D 8B3F 9BZ0 9ER2 9FD2
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Mesenchyme Migration Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of RNA Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Protein Localization To Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Protein Stability Regulation Of Metabolic Process Cell Body Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Initiation Protein Tag Activity Replicative Senescence Regulation Of Stem Cell Proliferation Regulation Of DNA Biosynthetic Process Chromatin DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Nucleus Regulation Of Cell Cycle Mitochondrion Organization Negative Regulation Of Telomere Maintenance Via Telomerase PML Body Regulation Of Telomere Maintenance Telomerase RNA Binding Regulation Of DNA Metabolic Process Regulation Of Protein Metabolic Process Ubiquitin-like Protein Ligase Binding Regulation Of RNA Metabolic Process Negative Regulation Of Stem Cell Proliferation Response To X-ray Nuclear Matrix Histone Deacetylase Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Circadian Rhythm Negative Regulation Of DNA Metabolic Process Cellular Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Translation Ribosome Macromolecule Metabolic Process RNA Binding Macromolecule Biosynthetic Process Structural Constituent Of Ribosome Ribonucleoprotein Complex Mitochondrial Translation Nucleoplasm Protein Metabolic Process NuRD Complex Mitochondrial Large Ribosomal Subunit Mitochondrial Inner Membrane Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Nucleus Protein-RNA Complex Assembly Cytosolic Ribosome Ubiquitin Protein Ligase Binding Nucleic Acid Metabolic Process PML Body Regulation Of Stem Cell Differentiation Small Protein Activating Enzyme Binding Cytoplasmic Translation Formation Of Cytoplasmic Translation Initiation Complex Chromosome, Telomeric Region Eukaryotic Translation Initiation Factor 3 Complex Nucleobase-containing Compound Metabolic Process Eukaryotic 48S Preinitiation Complex Protein Sumoylation Mitochondrion Eukaryotic 43S Preinitiation Complex Cytoplasmic Translational Initiation Chromatin Organization Protein-containing Complex Nucleosomal DNA Binding Nucleolus DNA Repair Chromatin Remodeling Mitochondrial Ribosome Regulation Of Protein Metabolic Process Transcription-coupled Nucleotide-excision Repair Translational Initiation Nucleotide-excision Repair Protein-containing Complex Organization DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Protein-containing Complex Assembly Chromosome
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