STAMBP and MAP2K5

Number of citations of the paper that reports this interaction (PMID 16730941)
46

Data Source:
HPRD (two hybrid)

		STAMBP	MAP2K5
Gene Name		STAM binding protein	mitogen-activated protein kinase kinase 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Early Endosome Plasma Membrane Cleavage Furrow Extracellular Vesicular Exosome	Intracellular Nucleus Spindle Cytosol
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Mitotic Cytokinesis Proteolysis JAK-STAT Cascade Positive Regulation Of Cell Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Deubiquitination Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Signal Transduction Heart Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Signalling to ERK5 Signalling by NGF NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS			Body mass index ( 22344219 20935630) Obesity ( 23563607) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		39 interactors: ALAS1 AMN BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 EPS15 GRAP2 GRB2 ITGA5 MAP2K5 MAP3K2 NTPCR PJA1 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SPG7 STAM STAM2 TNFRSF1A TRAF6 TRIP13 UACA UBC UBE2S USP21 USP28	15 interactors: ASRGL1 BAD CDC42BPB ESRRA MAP3K2 MAP3K3 MAPK7 PARD6A PRKCI PRKCZ RPL28 SQSTM1 STAMBP XRCC6 YWHAZ
Entrez ID		10617	5607
HPRD ID		05877	03951
Ensembl ID		ENSG00000124356	ENSG00000137764
Uniprot IDs		O95630	A6NK28 Q13163
PDB IDs		2XZE 3RZU 3RZV	2NPT 2O2V 4IC7
Enriched GO Terms of Interacting Partners?		Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Metaphase Plate Congression Vacuolar Transport Regulation Of Centrosome Duplication Establishment Of Chromosome Localization Endosomal Transport Regulation Of Centrosome Cycle Mitotic Sister Chromatid Segregation Mitotic Nuclear Division Sister Chromatid Segregation Chromosome Segregation Positive Regulation Of Viral Release From Host Cell Nucleus Organization Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Cycle Process Intracellular Transport Membrane Organization Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Viral Process Negative Regulation Of ERBB Signaling Pathway Protein Transport Mitotic Cell Cycle Viral Life Cycle Establishment Of Localization In Cell Establishment Of Protein Localization Regulation Of Mitotic Nuclear Division Regulation Of Protein Complex Assembly Regulation Of Viral Release From Host Cell Cellular Localization Virion Assembly Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Protein Localization Viral Budding Via Host ESCRT Complex Regulation Of Cellular Component Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Signaling Viral Budding Intracellular Signal Transduction Establishment Of Organelle Localization Regulation Of Cell Cycle Process Regulation Of Cytoskeleton Organization	Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Response To Growth Factor Signal Transduction Cellular Response To Stimulus Phosphorylation Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Signal Transduction Response To Stimulus Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Membrane Potential Positive Regulation Of Kinase Activity Intracellular Transport Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Endothelial Cell Apoptotic Process Response To Transforming Growth Factor Beta Positive Regulation Of Autophagy Positive Regulation Of Glucose Import Cellular Protein Modification Process Regulation Of Cellular Localization Positive Regulation Of Glucose Transport Viral Process Positive Regulation Of Transferase Activity
Tagcloud ?			amico atm dissect entered erg formalin fusions hiseq illumina maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Difference) ?			amico atm dissect entered erg formalin fusions hiseq illumina maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Intersection) ?