STAMBP and ATG14

Number of citations of the paper that reports this interaction (PubMedID 37632749)
0

Data Source:
BioGRID (enzymatic study)

		STAMBP	ATG14
Description		STAM binding protein	autophagy related 14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome	Phagophore Assembly Site Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Axoneme Membrane Cytoplasmic Vesicle Protein-containing Complex Phagophore Assembly Site Membrane Phosphatidylinositol 3-kinase Complex, Class III Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Phagocytic Vesicle Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane
	Molecular Function	Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Protein Domain Specific Binding Metal Ion Binding K63-linked Deubiquitinase Activity Deubiquitinase Activity Metal-dependent Deubiquitinase Activity	Protein Binding Phosphatidylinositol 3-kinase Regulator Activity Protein-membrane Adaptor Activity GTPase Binding Phosphatidylinositol 3-kinase Inhibitor Activity
	Biological Process	Mitotic Cytokinesis Proteolysis Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Protein Deubiquitination Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K63-linked Deubiquitination Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process	Autophagosome Assembly Mitophagy Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Targeting To Lysosome Autophagy Endosome To Lysosome Transport Cellular Response To Starvation Post-transcriptional Regulation Of Gene Expression Macroautophagy Autophagosome Membrane Docking Regulation Of Macroautophagy Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Early Endosome To Late Endosome Transport Innate Immune Response Defense Response To Virus Regulation Of Protein Complex Stability Regulation Of Triglyceride Metabolic Process Autophagosome Maturation Response To Mitochondrial Depolarisation
Pathways		Metalloprotease DUBs	Macroautophagy SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Anti-saccade response ( 29064472) Bell's palsy ( 33602968) Blood metabolite levels ( 26401656) Serum metabolite levels ( 23093944 33031748)	Eosinophil percentage of white cells ( 32888494) Platelet distribution width ( 27863252) Statin-induced myopathy ( 31220337) Testicular germ cell tumor ( 28604728) White blood cell count ( 32888494)
Interacting Genes		51 interacting genes: ALAS1 AMN APOBEC3A ATG14 BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 DSCR9 EGFR EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 MLKL NLRP7 NTPCR PJA1 RBM11 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S ULK1 USP21 USP28 VHL	14 interacting genes: ATG13 EXOC1 FSD2 MARCHF7 MIS18A OTUD3 OTUD7B RACK1 SNAPIN STAMBP STYK1 ULK2 USP2 YOD1
Entrez ID		10617	22863
HPRD ID		05877	13820
Ensembl ID		ENSG00000124356	ENSG00000126775
Uniprot IDs		A0A140VK54 A0A804HIF8 A0A804HII8 A0A804HJ64 O95630	Q6ZNE5
PDB IDs		2XZE 3RZU 3RZV 5IXF	6HOL 8SOR 9C82 9MHF 9MHG 9MHH
Enriched GO Terms of Interacting Partners?		ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Organization Multivesicular Body Assembly Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Late Endosome To Vacuole Transport Lysosomal Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Kinetochore Microtubule Autophagosome Membrane Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Regulation Of Mitotic Spindle Organization Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Endosome Organization Regulation Of Spindle Assembly Autophagy Cytokinetic Process Protein-containing Complex Disassembly Endosomal Transport Multivesicular Body Mitotic Metaphase Chromosome Alignment Biological Process Involved In Interaction With Host Nuclear Membrane Organization Vacuolar Transport Vacuole Organization Metaphase Chromosome Alignment Membrane Assembly Endosome Macroautophagy Regulation Of Microtubule Cytoskeleton Organization Chromosome Localization Lysosomal Transport Regulation Of Centrosome Duplication Nuclear Pore Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Nucleus Organization	Protein Deubiquitination Protein Modification By Small Protein Removal Protein K11-linked Deubiquitination Cysteine-type Deubiquitinase Activity Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Post-translational Protein Modification Cysteine-type Peptidase Activity Protein K27-linked Deubiquitination Protein Modification Process Peptidase Activity Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Piecemeal Microautophagy Of The Nucleus K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Protein Metabolic Process Phagophore Assembly Site Membrane Microautophagy Nucleophagy Perinuclear Region Of Cytoplasm Deubiquitinase Activity Negative Regulation Of Intracellular Signal Transduction Macroautophagy Phagophore Assembly Site Cyclin Binding Vacuole Organization Negative Regulation Of Cell Projection Organization Cytosol Rescue Of Stalled Ribosome Ribosome Disassembly Cytoplasm Somatic Sensory System Development Positive Regulation Of Late Endosome To Lysosome Transport Protein Stabilization Mitophagy Translational Elongation Mitotic Cytokinesis Autophagy Autophagy Of Mitochondrion IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Negative Regulation Of Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Organelle Disassembly Autophagosome Negative Regulation Of Cellular Component Organization Hippocampal Neuron Apoptotic Process Protein K6-linked Deubiquitination Pericentric Heterochromatin Organization
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