STAMBP and NLRP7

Number of citations of the paper that reports this interaction (PubMedID 28492230)
52

Data Source:
BioGRID (enzymatic study)

		STAMBP	NLRP7
Description		STAM binding protein	NLR family pyrin domain containing 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome	Cytoplasm
	Molecular Function	Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Protein Domain Specific Binding Metal Ion Binding K63-linked Deubiquitinase Activity Deubiquitinase Activity Metal-dependent Deubiquitinase Activity	Nucleotide Binding ATP Binding Aspartic-type Endopeptidase Inhibitor Activity Interleukin-1 Binding Identical Protein Binding Caspase Binding
	Biological Process	Mitotic Cytokinesis Proteolysis Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Protein Deubiquitination Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K63-linked Deubiquitination Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process	Negative Regulation Of Protein Processing Negative Regulation Of Interleukin-1 Beta Production Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Metalloprotease DUBs
Drugs
Diseases			Recurrent hydatidiform moles (RHM); Familial biparental hydatidiform
GWAS		Anti-saccade response ( 29064472) Bell's palsy ( 33602968) Blood metabolite levels ( 26401656) Serum metabolite levels ( 23093944 33031748)	Inflammatory bowel disease ( 23128233)
Interacting Genes		51 interacting genes: ALAS1 AMN APOBEC3A ATG14 BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 DSCR9 EGFR EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 MLKL NLRP7 NTPCR PJA1 RBM11 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S ULK1 USP21 USP28 VHL	2 interacting genes: FAF1 STAMBP
Entrez ID		10617	199713
HPRD ID		05877	10112
Ensembl ID		ENSG00000124356	ENSG00000167634
Uniprot IDs		A0A140VK54 A0A804HIF8 A0A804HII8 A0A804HJ64 O95630	A0A0G2JNK3 K7ERG0 Q8WX94
PDB IDs		2XZE 3RZU 3RZV 5IXF	2KM6
Enriched GO Terms of Interacting Partners?		ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Organization Multivesicular Body Assembly Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Late Endosome To Vacuole Transport Lysosomal Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Kinetochore Microtubule Autophagosome Membrane Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Regulation Of Mitotic Spindle Organization Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Endosome Organization Regulation Of Spindle Assembly Autophagy Cytokinetic Process Protein-containing Complex Disassembly Endosomal Transport Multivesicular Body Mitotic Metaphase Chromosome Alignment Biological Process Involved In Interaction With Host Nuclear Membrane Organization Vacuolar Transport Vacuole Organization Metaphase Chromosome Alignment Membrane Assembly Endosome Macroautophagy Regulation Of Microtubule Cytoskeleton Organization Chromosome Localization Lysosomal Transport Regulation Of Centrosome Duplication Nuclear Pore Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Nucleus Organization	Protein Domain Specific Binding Hippocampal Neuron Apoptotic Process Ooplasm Fas Signaling Pathway Negative Regulation Of Hippocampal Neuron Apoptotic Process Regulation Of Hippocampal Neuron Apoptotic Process CD95 Death-inducing Signaling Complex VCP-NPL4-UFD1 AAA ATPase Complex Metal-dependent Deubiquitinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intracellular Signal Transduction K63-linked Deubiquitinase Activity Protein Kinase Regulator Activity Cell Death Apoptotic Process Protein K63-linked Deubiquitination Deubiquitinase Activity Programmed Cell Death Negative Regulation Of Ras Protein Signal Transduction NF-kappaB Binding Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Mitotic Cytokinesis Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Communication Regulation Of Ras Protein Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cleavage Furrow Proteolysis Negative Regulation Of Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Heat Shock Protein Binding Positive Regulation Of DNA Replication Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Via STAT Cytoskeleton-dependent Cytokinesis ERAD Pathway Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Binding Protein Modification By Small Protein Removal Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of DNA Replication Metallopeptidase Activity Positive Regulation Of Apoptotic Signaling Pathway
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