SPRED2 and SPG21

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SPRED2	SPG21
Gene Name		sprouty-related, EVH1 domain containing 2	spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Transport Vesicle Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	Protein Binding CD4 Receptor Binding
	Biological Process	Inactivation Of MAPK Activity Multicellular Organismal Development Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Deacetylation	Antigen Receptor-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967) Inflammatory bowel disease ( 23128233) Rheumatoid arthritis ( 20453842)
Protein-Protein Interactions		5 interactors: KIT RHOA SPG21 TOP3B ZDHHC17	37 interactors: AGTRAP AKIRIN2 ARL6IP1 ATPAF2 CCDC102B CCDC33 CD4 CMTM5 CRYAA CTPS2 CUTC DTX2 DTX3L EFHC2 FAM114A1 GGA2 GSK3A IKZF3 INCA1 KRT15 MID2 MTMR9 PRPS1 RABAC1 REEP6 RTN4 S100B SPRED2 TCF12 TCF4 TFG TRAF1 TRAF2 TRIM23 TRIM54 TRIM9 ZNF263
Entrez ID		200734	51324
HPRD ID		18100	10492
Ensembl ID		ENSG00000198369	ENSG00000090487
Uniprot IDs		B3KPL5 Q7Z698	Q9NZD8
PDB IDs		2JP2
Enriched GO Terms of Interacting Partners?		Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Phosphatidylinositol-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mast Cell Differentiation Skeletal Muscle Satellite Cell Migration Cellular Response To Erythropoietin Mast Cell Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Bone Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apolipoprotein A-I-mediated Signaling Pathway Melanocyte Migration Cleavage Furrow Formation Positive Regulation Of Cell Projection Organization Positive Regulation Of Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Myeloid Progenitor Cell Differentiation Cellular Response To Thyroid Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Lymphoid Progenitor Cell Differentiation Positive Regulation Of Pseudopodium Assembly Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Neurogenesis Ectopic Germ Cell Programmed Cell Death Immature B Cell Differentiation Cytokine Production Involved In Immune Response Cell Division Megakaryocyte Development Response To Thyroid Hormone Ossification Involved In Bone Maturation Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Bone Maturation Regulation Of Cell Projection Organization Negative Chemotaxis Mitotic Spindle Assembly Lipoprotein Transport Germ Cell Migration	Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Ubiquitination Regulation Of Cell Death Protein Modification By Small Protein Conjugation Negative Regulation Of Developmental Growth Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-2 Production Positive Regulation Of Cell Death Immune Response Negative Regulation Of Organ Growth Negative Regulation Of UDP-glucose Catabolic Process Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Regulation Of Intracellular Signal Transduction Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Striated Muscle Tissue Development Regulation Of Cellular Localization Negative Regulation Of Muscle Organ Development Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Pyrimidine Nucleotide Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of SNARE Complex Assembly Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Urate Biosynthetic Process 'de Novo' CTP Biosynthetic Process Glycogen Metabolic Process Regulation Of Kinase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Differentiation Positive Regulation Of Protein Binding Regulation Of Skeletal Muscle Tissue Development Regulation Of Cellular Ketone Metabolic Process Gliogenesis Negative Regulation Of Growth Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Tagcloud ?		3g bim bolsters btg3 cdc25a cfue cyclinb1 deployed eaf1 engages epo epor erythroblast erythroblasts gas5 interrogate lyl1 maturing pim1 pim3 presently proerythroblast serpina sf13c socs2 sophisticated tnfr trib3
Tagcloud (Difference) ?		3g bim bolsters btg3 cdc25a cfue cyclinb1 deployed eaf1 engages epo epor erythroblast erythroblasts gas5 interrogate lyl1 maturing pim1 pim3 presently proerythroblast serpina sf13c socs2 sophisticated tnfr trib3
Tagcloud (Intersection) ?