SPRED2 and KPRP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPRED2	KPRP
Description		sprouty related EVH1 domain containing 2	keratinocyte proline rich protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle	Cytoplasm Extracellular Exosome
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	Protein Binding
	Biological Process	Regulation Of Signal Transduction Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Lens Fiber Cell Differentiation	Desmosome Organization Inflammatory Response Epidermis Development Skin Development Establishment Of Skin Barrier
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Body size at age 10 ( 32376654) Celiac disease or Rheumatoid arthritis ( 21383967) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 33020668) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gamma glutamyl transferase levels ( 33339817 29403010) Glaucoma (primary open-angle) ( 33627673) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 27569725) Intraocular pressure ( 29617998) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Red blood cell count ( 32888494) Rheumatoid arthritis ( 23143596 24390342 24782177 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 27399966) Systolic blood pressure ( 31647587) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 30275531) White blood cell count ( 32888494 27863252)	Asthma ( 31619474) Psoriasis ( 25854761)
Interacting Genes		30 interacting genes: AQP1 CTSD DYRK1A KCNIP1 KIT KPRP KRTAP12-2 KRTAP2-3 KRTAP2-4 LCE1C LCE2B LCE5A MDFI MTDH MYO15B NCS1 NDUFB7 QARS1 RBM48 RHOA RPS6KA6 SPG21 TOP3B TSNAX VSNL1 ZNF250 ZNF414 ZNF417 ZNF575 ZNF837	110 interacting genes: ACTMAP AKAP8L ANKS1A ATG9A BTC CATSPER1 CCDC57 CES1 CKS1B CLCNKA CNFN CNNM3 COL8A1 CREB5 CYSRT1 DARS1-AS1 DMRT3 DYRK1A EIF3E ESR2 FAM221B FAM72B FBXO17 FCHO1 FHL2 FHL3 FRS3 GNE GRAP2 GRB2 GUCD1 HCK HEXIM2 HNRNPF HOXA1 HOXC8 HSD3B7 ITGB4 ITIH6 KRTAP1-3 KRTAP1-5 KRTAP10-8 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP3-2 KRTAP4-2 KRTAP4-5 KRTAP5-3 KRTAP5-7 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-3 LCE3A LCE3C LCE3D LCE3E LIMS1 LMO2 LNX1 MAPKBP1 MEOX2 MGAT5B MIIP MLH1 NBPF19 NCK2 NID2 NOTCH2NLA NPBWR2 NR4A3 NTN4 NUFIP2 OTX1 PDGFRB PHLDA1 PLA2G10 PLSCR4 POU4F2 PPIL1 RANBP3 RBP3 RGL2 RNF38 SAXO4 SEMA3B SH3KBP1 SLC15A2 SPRED2 SPRY1 SPRY3 STK16 TEKT4 TFAP2D TNS2 TRIM42 TRIP6 UBASH3A UBASH3B VGLL3 VWC2 ZNF587
Entrez ID		200734	448834
HPRD ID		18100	18838
Ensembl ID		ENSG00000198369	ENSG00000203786
Uniprot IDs		B3KPL5 Q7Z698	Q5T749
PDB IDs		2JP2 8EQ5
Enriched GO Terms of Interacting Partners?			Intermediate Filament Protein Binding Keratin Filament Keratinization
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