SPRED2 and TOP3B

Number of citations: 71 (PubMedID 35748872)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		SPRED2	TOP3B
Name		sprouty related EVH1 domain containing 2	DNA topoisomerase III beta
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle	Condensed Chromosome Nucleus DNA Topoisomerase III-beta-TDRD3 Complex
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Isomerase Activity RNA Topoisomerase Activity
	Biological Process	Regulation Of Signal Transduction Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Lens Fiber Cell Differentiation	DNA Topological Change DNA Repair DNA Recombination Chromosome Segregation
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants	None
GWAS		Appendicular lean mass ( 33097823 ) Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Body size at age 10 ( 32376654 ) Celiac disease or Rheumatoid arthritis ( 21383967 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Coronary artery disease ( 33020668 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Gamma glutamyl transferase levels ( 33339817 29403010 ) Glaucoma (primary open-angle) ( 33627673 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Inflammatory bowel disease ( 23128233 27569725 ) Intraocular pressure ( 29617998 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400 ) Red blood cell count ( 32888494 ) Rheumatoid arthritis ( 23143596 24390342 24782177 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Severe influenza A (H1N1) infection ( 26379185 ) Sum eosinophil basophil counts ( 27863252 ) Systemic lupus erythematosus ( 26502338 27399966 ) Systolic blood pressure ( 31647587 ) Tonsillectomy ( 27182965 28928442 ) Total cholesterol levels ( 30275531 ) White blood cell count ( 32888494 27863252 )	Attention function in attention deficit hyperactive disorder ( 26174813 ) Bipolar disorder ( 31043756 ) Diastolic blood pressure ( 29208002 ) Response to selective serotonin reuptake inhibitors in depression ( 27622933 )
Interacting Genes		30 interacting genes: AQP1 CTSD DYRK1A KCNIP1 KIT KPRP KRTAP12-2 KRTAP2-3 KRTAP2-4 LCE1C LCE2B LCE5A MDFI MTDH MYO15B NCS1 NDUFB7 QARS1 RBM48 RHOA RPS6KA6 SPG21 TOP3B TSNAX VSNL1 ZNF250 ZNF414 ZNF417 ZNF575 ZNF837	25 interacting genes: ADAMTSL4 AXIN2 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GPRASP3 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TDRD3 TRIM41 UPF2 ZFPM1 ZNF250 ZNF408
Entrez ID		200734	8940
HPRD ID		18100	04662
Ensembl ID		ENSG00000198369	ENSG00000100038
Uniprot IDs		B3KPL5 Q7Z698	A8K4N2 O95985
PDB IDs		2JP2 8EQ5	5GVC 5GVE 9C9W 9C9Y 9CA0 9CA1 9CA4 9CAG 9CAH 9CAJ 9CAK 9CAL