SPRED2 and TOP3B

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SPRED2	TOP3B
Gene Name		sprouty-related, EVH1 domain containing 2	topoisomerase (DNA) III beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Transport Vesicle Membrane	Condensed Chromosome Nucleus Nucleoplasm
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I Activity Poly(A) RNA Binding
	Biological Process	Inactivation Of MAPK Activity Multicellular Organismal Development Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Deacetylation	DNA Topological Change Chromosome Segregation
Pathways
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967) Inflammatory bowel disease ( 23128233) Rheumatoid arthritis ( 20453842)
Protein-Protein Interactions		5 interactors: KIT RHOA SPG21 TOP3B ZDHHC17	18 interactors: ADAMTSL4 C1QBP CENPF CHD8 CHIC2 FBLN5 GRN KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF408
Entrez ID		200734	8940
HPRD ID		18100	04662
Ensembl ID		ENSG00000198369	ENSG00000100038
Uniprot IDs		B3KPL5 Q7Z698	A8K4N2 O95985
PDB IDs		2JP2
Enriched GO Terms of Interacting Partners?		Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Phosphatidylinositol-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mast Cell Differentiation Skeletal Muscle Satellite Cell Migration Cellular Response To Erythropoietin Mast Cell Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Bone Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apolipoprotein A-I-mediated Signaling Pathway Melanocyte Migration Cleavage Furrow Formation Positive Regulation Of Cell Projection Organization Positive Regulation Of Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Myeloid Progenitor Cell Differentiation Cellular Response To Thyroid Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Lymphoid Progenitor Cell Differentiation Positive Regulation Of Pseudopodium Assembly Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Neurogenesis Ectopic Germ Cell Programmed Cell Death Immature B Cell Differentiation Cytokine Production Involved In Immune Response Cell Division Megakaryocyte Development Response To Thyroid Hormone Ossification Involved In Bone Maturation Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Bone Maturation Regulation Of Cell Projection Organization Negative Chemotaxis Mitotic Spindle Assembly Lipoprotein Transport Germ Cell Migration	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Interleukin-4 Biosynthetic Process Negative Regulation Of Mast Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription DNA Duplex Unwinding DNA Geometric Change Positive Regulation Of Trophoblast Cell Migration Negative Regulation Of MDA-5 Signaling Pathway Mitral Valve Formation Cellular Macromolecule Biosynthetic Process Regulation Of Interferon-gamma Production Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Transcriptional Activation By Promoter-enhancer Looping Tricuspid Valve Formation Tricuspid Valve Morphogenesis Primitive Erythrocyte Differentiation Tricuspid Valve Development Blood Coagulation Hemostasis Regulation Of Definitive Erythrocyte Differentiation Regulation Of Mast Cell Differentiation Intraciliary Transport Involved In Cilium Morphogenesis Positive Regulation Of Mitochondrial Translation Mitral Valve Morphogenesis Definitive Erythrocyte Differentiation Organelle Assembly Cellular Localization Negative Regulation Of Interleukin-4 Production Positive Regulation Of Dendritic Cell Chemotaxis Mitral Valve Development Elastic Fiber Assembly Chromosome Organization Protein Localization To Microtubule
Tagcloud ?		3g bim bolsters btg3 cdc25a cfue cyclinb1 deployed eaf1 engages epo epor erythroblast erythroblasts gas5 interrogate lyl1 maturing pim1 pim3 presently proerythroblast serpina sf13c socs2 sophisticated tnfr trib3	accelerate advancing aging bubr1 claimed ebp ghr ghrhr gompertz insr instance interpreted klotho lmna longevity msra pit1 polga prdx1 prop1 prove retard shc1 span straightforward tables terc trx wrn
Tagcloud (Difference) ?		3g bim bolsters btg3 cdc25a cfue cyclinb1 deployed eaf1 engages epo epor erythroblast erythroblasts gas5 interrogate lyl1 maturing pim1 pim3 presently proerythroblast serpina sf13c socs2 sophisticated tnfr trib3	accelerate advancing aging bubr1 claimed ebp ghr ghrhr gompertz insr instance interpreted klotho lmna longevity msra pit1 polga prdx1 prop1 prove retard shc1 span straightforward tables terc trx wrn
Tagcloud (Intersection) ?