CSNK2B and POT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CSNK2B	POT1
Description		casein kinase 2 beta	protection of telomeres 1
Image
GO Annotations	Cellular Component	Chromatin Fibrillar Center Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex PML Body PcG Protein Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Shelterin Complex
	Molecular Function	Chromatin Binding Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding Protein Kinase Regulator Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	DNA Binding Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding G-rich Strand Telomeric DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding G-rich Single-stranded DNA Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Release From Viral Latency Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of SMAD Protein Signal Transduction Endothelial Tube Morphogenesis Protein-containing Complex Assembly Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Viral Life Cycle	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Strand Elongation Telomeric D-loop Disassembly Establishment Of Protein Localization To Telomere Positive Regulation Of Telomeric D-loop Disassembly Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity KEAP1-NFE2L2 pathway Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins SPOP-mediated proteasomal degradation of PD-L1(CD274) Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs		ATP Quercetin
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Systemic lupus erythematosus ( 26316170) Ulcerative colitis ( 28067908)	Chronic lymphocytic leukemia ( 24292274 28165464) Cutaneous malignant melanoma ( 26237428) Leukocyte telomere length ( 31171785 32109421) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Telomere length ( 33941849)
Interacting Genes		222 interacting genes: ABHD4 ACTB ACTL6B ACTR1B ACTR5 ACVRL1 ADD1 ADH5 ANGPT2 ANKRD28 AP2M1 APLP1 ARAF ATF1 ATG101 ATXN3 BAG6 BANP BCCIP BHLHE41 BID BMI1 BRCA1 BTF3 C6orf136 CACNA1A CALM1 CCDC187 CCNB1 CCNH CD163 CD81 CDC25B CDC34 CDK1 CDK20 CDKN1A CHEK1 CHRNA4 CIC CIPC CLOCK COIL COL4A2 COPS3 COPS7A CPNE7 CREB1 CSN1S1 CSN2 CSNK1E CSNK2A1 CSNK2A2 CST1 CTDP1 CTNNB1 DACT1 DALRD3 DAXX DELEC1 DENND5A DNMT1 DPF3 DSCAM DUX1 DYNLT2B EIF2S2 EIF5 EIF6 EPS8 ERCC6 ERCC8 ESR1 FAF1 FAM86C1P FBXL15 FBXL5 FGB FGF1 FGF2 FIBP FKBP3 FTH1 FXR1 FXR2 GADD45GIP1 GAMT GBP2 GLB1 GLIS2 GNB5 GRIN2A GRIN2B GRK2 GSK3B HEXB HNRNPA2B1 HOXB5 HOXB6 HTRA1 HYPK IER3IP1 INO80B INTS11 IRS1 ITSN1 KDM6B KIF2C LCK LEPR LMO4 LRP5L LTB4R2 LYN LYST MAPK14 MBD4 MDM2 MME MOXD1 MPP2 NAP1L1 NCF1 NGDN NMT2 NOLC1 NOTCH3 NPAS2 NRBP1 NRF1 NTAQ1 ODC1 OGA OGT PDS5A PER1 PER2 PFKFB4 PHF11 PIMREG PIN1 PITPNA PLXNA3 POT1 PPID PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E PPP3CC PRKAB2 PRKCZ PRNP PROC PTPRK PTTG2 PYROXD2 RAD17 RAD51 RFC1 RNF126 RNF7 RORB RPA1 RPL13 RPL41 RPL5 RPS6KB1 RRAD RXRA SARNP SDHA SEC11A SELENOI SHMT1 SHMT2 SIMC1 SNX2 SPOUT1 SPSB3 SSB STAT5A STAU1 STK16 SUMO2 SYNE4 TCEAL7 TENM1 TFAP2A TFAP2D TLE1 TLX3 TNFAIP1 TOP2B TP53 TP53BP2 TP63 TRIM54 TSEN54 TUBB2B TWF1 UBE2I UPF1 USO1 UTP14A VDAC1 VMA22 VRK3 WDR1 WDR18 WFIKKN1 WWOX ZNF19 ZNF410 ZNF44 ZNF71 ZNF784 ZNHIT1	166 interacting genes: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C2orf74 CALD1 CAMK1D CCDC32 CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN H2AC20 HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 PYM1 RBKS RECQL4 RGS14 RHOU RIF1 RPAP1 RPSA RTN4 SARS1 SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790
Entrez ID		1460	25913
HPRD ID		00278	07572
Ensembl ID		ENSG00000204435	ENSG00000128513
Uniprot IDs		A0A1U9X7J2 N0E4C7 P67870	A8MTK3 Q5MJ33 Q9NUX5
PDB IDs		1DS5 1JWH 1QF8 3EED 4DGL 4MD7 4MD8 4MD9 4NH1 6Q38	1XJV 3KJO 3KJP 5H65 5UN7 7QXB 7QXS 7S1O 7S1T 7S1U 8SH0 8SH1 8SOJ 8SOK
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Protein Binding Regulation Of Cell Cycle Cytoplasm Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process DNA Damage Response Rhythmic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Gene Expression Chromosome Organization Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Regulation Of Cell Cycle Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Circadian Regulation Of Gene Expression Nucleic Acid Metabolic Process Circadian Rhythm Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Photoperiodism Negative Regulation Of Metabolic Process DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Response To Radiation Signal Transduction In Response To DNA Damage Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Cellular Response To Oxygen-containing Compound Cell Cycle Phase Transition Intracellular Signal Transduction	Cytoplasm Cytosol Extracellular Exosome Cytoskeleton Organization Actin Filament Organization Cytoskeleton Protein Binding Cadherin Binding Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Supramolecular Fiber Organization Cellular Response To Heat Actin Binding Carbohydrate Catabolic Process Response To Heat Pyruvate Metabolic Process Organelle Organization Glycolytic Process Nucleoside Phosphate Metabolic Process ADP Catabolic Process Vesicle Purine Nucleotide Metabolic Process Identical Protein Binding Generation Of Precursor Metabolites And Energy Purine Ribonucleoside Diphosphate Catabolic Process Small Molecule Metabolic Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Response To Temperature Stimulus Nucleoside Diphosphate Catabolic Process Purine Nucleotide Catabolic Process Ficolin-1-rich Granule Lumen Glucose Metabolic Process Microtubule Cytoskeleton Organization Nucleoside Phosphate Catabolic Process Actin Filament-based Process Actin Cytoskeleton Organization Monocarboxylic Acid Metabolic Process Nucleotide Metabolic Process Negative Regulation Of Cellular Component Organization Cytoskeletal Protein Binding Protein Sequestering Activity Focal Adhesion Catabolic Process Monosaccharide Metabolic Process Actin Monomer Binding Cellular Response To Raffinose Nucleotide Catabolic Process Organic Acid Metabolic Process
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