CSNK2B and LEPR

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		CSNK2B	LEPR
Description		casein kinase 2 beta	leptin receptor
Image
GO Annotations	Cellular Component	Chromatin Fibrillar Center Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex PML Body PcG Protein Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Chromatin Binding Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding Protein Kinase Regulator Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Leptin Receptor Activity Signaling Receptor Activity Identical Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Release From Viral Latency Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of SMAD Protein Signal Transduction Endothelial Tube Morphogenesis Protein-containing Complex Assembly Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Viral Life Cycle	Angiogenesis Glycogen Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Phagocytosis Cell Surface Receptor Signaling Pathway Multicellular Organism Development Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy Glial Cell Proliferation Cytokine-mediated Signaling Pathway Sexual Reproduction T Cell Differentiation Leptin-mediated Signaling Pathway Glucose Homeostasis Response To Leptin Negative Regulation Of Gluconeogenesis Regulation Of Bone Remodeling System Development Regulation Of Transport Regulation Of Feeding Behavior Energy Homeostasis Cell Surface Receptor Signaling Pathway Via STAT Bone Growth Positive Regulation Of Cold-induced Thermogenesis Transport Across Blood-brain Barrier
Pathways		Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity KEAP1-NFE2L2 pathway Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins SPOP-mediated proteasomal degradation of PD-L1(CD274) Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs		ATP Quercetin	Leptin Metreleptin
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Systemic lupus erythematosus ( 26316170) Ulcerative colitis ( 28067908)	Adult body size ( 32376654) Age at voice drop ( 27182965) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Blood protein levels ( 30072576) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) BMI at 3 months old ( 31575865) BMI at 6 months old ( 31575865) BMI at 8 months old ( 31575865) BMI at adiposity peak ( 31840077) Body size at age 10 ( 32376654) C-reactive protein ( 23844046 18439548 22939635 19567438) C-reactive protein levels ( 33339817 21300955 29878111 30388399) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Eosinophil percentage of white cells ( 32888494) Fasting plasma glucose (childhood) ( 25223902) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Hip circumference ( 28552196) Iron status biomarkers (iron levels) ( 33536631) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Metabolic traits ( 19060910) Molybdenum levels ( 26025379) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Nonalcoholic steatohepatitis ( 32298765) Obesity (early onset extreme) ( 23563609) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum alkaline phosphatase levels ( 33547301) Soluble leptin receptor levels ( 20167575) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)
Interacting Genes		222 interacting genes: ABHD4 ACTB ACTL6B ACTR1B ACTR5 ACVRL1 ADD1 ADH5 ANGPT2 ANKRD28 AP2M1 APLP1 ARAF ATF1 ATG101 ATXN3 BAG6 BANP BCCIP BHLHE41 BID BMI1 BRCA1 BTF3 C6orf136 CACNA1A CALM1 CCDC187 CCNB1 CCNH CD163 CD81 CDC25B CDC34 CDK1 CDK20 CDKN1A CHEK1 CHRNA4 CIC CIPC CLOCK COIL COL4A2 COPS3 COPS7A CPNE7 CREB1 CSN1S1 CSN2 CSNK1E CSNK2A1 CSNK2A2 CST1 CTDP1 CTNNB1 DACT1 DALRD3 DAXX DELEC1 DENND5A DNMT1 DPF3 DSCAM DUX1 DYNLT2B EIF2S2 EIF5 EIF6 EPS8 ERCC6 ERCC8 ESR1 FAF1 FAM86C1P FBXL15 FBXL5 FGB FGF1 FGF2 FIBP FKBP3 FTH1 FXR1 FXR2 GADD45GIP1 GAMT GBP2 GLB1 GLIS2 GNB5 GRIN2A GRIN2B GRK2 GSK3B HEXB HNRNPA2B1 HOXB5 HOXB6 HTRA1 HYPK IER3IP1 INO80B INTS11 IRS1 ITSN1 KDM6B KIF2C LCK LEPR LMO4 LRP5L LTB4R2 LYN LYST MAPK14 MBD4 MDM2 MME MOXD1 MPP2 NAP1L1 NCF1 NGDN NMT2 NOLC1 NOTCH3 NPAS2 NRBP1 NRF1 NTAQ1 ODC1 OGA OGT PDS5A PER1 PER2 PFKFB4 PHF11 PIMREG PIN1 PITPNA PLXNA3 POT1 PPID PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E PPP3CC PRKAB2 PRKCZ PRNP PROC PTPRK PTTG2 PYROXD2 RAD17 RAD51 RFC1 RNF126 RNF7 RORB RPA1 RPL13 RPL41 RPL5 RPS6KB1 RRAD RXRA SARNP SDHA SEC11A SELENOI SHMT1 SHMT2 SIMC1 SNX2 SPOUT1 SPSB3 SSB STAT5A STAU1 STK16 SUMO2 SYNE4 TCEAL7 TENM1 TFAP2A TFAP2D TLE1 TLX3 TNFAIP1 TOP2B TP53 TP53BP2 TP63 TRIM54 TSEN54 TUBB2B TWF1 UBE2I UPF1 USO1 UTP14A VDAC1 VMA22 VRK3 WDR1 WDR18 WFIKKN1 WWOX ZNF19 ZNF410 ZNF44 ZNF71 ZNF784 ZNHIT1	17 interacting genes: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 USP7 XRN1
Entrez ID		1460	3953
HPRD ID		00278	03001
Ensembl ID		ENSG00000204435	ENSG00000116678
Uniprot IDs		A0A1U9X7J2 N0E4C7 P67870	P48357 Q4G138
PDB IDs		1DS5 1JWH 1QF8 3EED 4DGL 4MD7 4MD8 4MD9 4NH1 6Q38	3V6O 6E2P 7Z3Q 8AVE 8AVF 8AVO 8X80 8X81 8X85
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Protein Binding Regulation Of Cell Cycle Cytoplasm Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process DNA Damage Response Rhythmic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Gene Expression Chromosome Organization Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Regulation Of Cell Cycle Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Circadian Regulation Of Gene Expression Nucleic Acid Metabolic Process Circadian Rhythm Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Photoperiodism Negative Regulation Of Metabolic Process DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Response To Radiation Signal Transduction In Response To DNA Damage Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Cellular Response To Oxygen-containing Compound Cell Cycle Phase Transition Intracellular Signal Transduction	Leptin Receptor Binding Retromer, Tubulation Complex Insulin Receptor Binding Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Peptide Hormone Receptor Binding Transferrin Receptor Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Metabolic Process Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Catabolic Process Regulation Of Autophagy Retromer Complex Negative Regulation Of Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Cytosol Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Autophagy Phosphatidylinositol Binding Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Regulation Of Hormone Secretion Regulation Of Intracellular Transport Epidermal Growth Factor Receptor Binding Regulation Of Nucleocytoplasmic Transport Regulation Of Transport Regulation Of Immune System Process Regulation Of Defense Response Regulation Of Intracellular Protein Transport Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Hormone Secretion Establishment Of Protein Localization Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Regulation Of Protein Localization To Nucleus
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