CSNK2B and GLB1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CSNK2B	GLB1
Gene Name		casein kinase 2, beta polypeptide	galactosidase, beta 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex PcG Protein Complex Extracellular Vesicular Exosome	Cytoplasm Vacuole Golgi Apparatus Lysosomal Lumen Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Binding Protein Binding Transcription Factor Binding Protein Kinase Regulator Activity Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding	Beta-galactosidase Activity Protein Binding Galactoside Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Signal Transduction Axon Guidance Negative Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Wnt Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Cellular Protein Complex Assembly Regulation Of Protein Kinase Activity Regulation Of DNA Binding Endothelial Tube Morphogenesis	Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Pathogenesis Protein N-linked Glycosylation Via Asparagine Galactose Catabolic Process Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways		Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes	Metabolism of lipids and lipoproteins Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective CHST14 causes EDS, musculocontractural type Myoclonic epilepsy of Lafora Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective EXT2 causes exostoses 2 Synthesis of substrates in N-glycan biosythesis Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective PAPSS2 causes SEMD-PA Defective ALG9 causes ALG9-CDG (CDG-1l) MPS IIIA - Sanfilippo syndrome A Defective MAN1B1 causes MRT15 MPS IIIC - Sanfilippo syndrome C Defective ALG11 causes ALG11-CDG (CDG-1p) Sphingolipid metabolism Glycosphingolipid metabolism Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome HS-GAG degradation
Drugs
Diseases
GWAS			Atopic dermatitis ( 23042114) Hepatocellular carcinoma ( 21105107)
Protein-Protein Interactions		175 interactors: ABHD4 ACTB ACTL6B ACTR1B ACTR5 ACVRL1 ADD1 ADH5 ADRBK1 ANGPT2 ANKRD28 AP2M1 APLP1 ARAF ATF1 ATG101 ATXN3 BAG6 BCCIP BID BMI1 BRCA1 BTF3 C6orf136 C9orf114 CACNA1A CALM1 CBX4 CCDC115 CCNH CD163 CD81 CDC25B CDC34 CDK1 CDK20 CDKN1A CENPB CHEK1 CHRNA4 CIC COIL COL4A2 COPS2 COPS3 COPS7A CPNE7 CPSF3L CSN1S1 CSN2 CSNK2A1 CSNK2A2 CTDP1 CTNNB1 DACT1 DALRD3 DENND5A DNMT1 EIF2S2 EIF5 EIF6 EPS8 ERCC8 ESR1 FAF1 FBXL5 FGB FGF1 FGF2 FIBP FKBP3 FTH1 GADD45GIP1 GAMT GBP2 GLB1 GNB5 HEXB HIRIP3 HNRNPA2B1 HOXB6 HTRA1 IER3IP1 IRS1 ITSN1 JUN KDM6B KIF2C LCK LEPR LMO4 LRP5L LYN LYST MAPK14 MBD4 MGEA5 MME MOXD1 MPP2 NAP1L1 NCF1 NMT2 NOLC1 NOTCH3 NRBP1 ODC1 PDS5A PFKFB4 PHC2 PHF11 PHRF1 PIN1 PITPNA PLXNA3 POT1 PPID PPP3CC PRKAB2 PRKCZ PRNP PROC PTPRK PYROXD2 RFC1 RNF126 RNF7 RPA1 RPL13 RPL41 RPL5 RPS6KA2 RPS6KA5 RPS6KB1 RPS6KB2 RRAD RXRA SARNP SDHA SEC11A SHANK3 SHMT1 SHMT2 SIMC1 SIRT1 SNX2 SPSB3 SSB STAT5A STAU1 STK16 SUMO2 SYNE4 TCEAL7 TCTEX1D2 TLE1 TNFAIP1 TOP2B TP53 TP53BP2 TSEN54 TUBB2B UBE2I UPF1 USO1 UTP14A VDAC1 VRK3 WDR1 WDR18 WFIKKN1 ZNF44 ZNF71 ZNF784 ZNHIT1	7 interactors: CSNK2B CTSA DNAJB1 FOS NEU1 PLK1 TK1
Entrez ID		1460	2720
HPRD ID		00278	01975
Ensembl ID		ENSG00000204435	ENSG00000170266
Uniprot IDs		N0E4C7 P67870 Q5SRQ6	P16278
PDB IDs		1DS5 1JWH 1QF8 3EED 4DGL	3THC 3THD
Enriched GO Terms of Interacting Partners?		Cellular Metabolic Process Response To Growth Factor Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Developmental Process Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Multicellular Organismal Development Regulation Of Cell Proliferation Anatomical Structure Development Metabolic Process Response To Organic Substance Regulation Of Cellular Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Macromolecule Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Cycle Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process System Development Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Stimulus Cell Cycle Positive Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Nitrogen Compound Metabolic Process Biosynthetic Process Cellular Protein Modification Process Cellular Response To Stimulus Cell Death Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Death Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Radiation Response To Radiation Positive Regulation Of Cell Proliferation Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Cellular Response To Light Stimulus Gene Expression Regulation Of Phosphorylation Peptidyl-amino Acid Modification Programmed Cell Death Cellular Aromatic Compound Metabolic Process	Response To Toxic Substance Dolichol-linked Oligosaccharide Biosynthetic Process Glycosphingolipid Metabolic Process Fetal Process Involved In Parturition Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Skeletal Muscle Cell Proliferation Activation Of APC-Cdc20 Complex Activity Glycolipid Metabolic Process Response To Glucocorticoid Sphingolipid Metabolic Process Response To Corticosteroid Positive Regulation Of Metabolic Process Phosphorylation Polar Body Extrusion After Meiotic Divisions Response To Temperature Stimulus Post-translational Protein Modification Response To Cortisol Chaperone Cofactor-dependent Protein Refolding Conditioned Taste Aversion Thymidine Metabolic Process Membrane Lipid Metabolic Process Activation Of Anaphase-promoting Complex Activity Meiotic Cytokinesis Response To Hormone Peptidyl-amino Acid Modification Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Activin Receptor Signaling Pathway Deoxyribonucleoside Monophosphate Biosynthetic Process Regulation Of Binding Adiponectin-activated Signaling Pathway Metaphase/anaphase Transition Of Mitotic Cell Cycle Oligosaccharide Catabolic Process Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Cellular Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Inclusion Body Assembly Cellular Protein Metabolic Process Endothelial Tube Morphogenesis Response To Organic Substance Protein Localization To Chromatin Response To Metal Ion Protein Glycosylation Macromolecule Glycosylation Glycosylation Sleep Response To Gravity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Chromosome Segregation
Tagcloud ?		bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis	acy acy1 acylamino aminoacylase aminohydrolase approximate assignment autosomal chromosome chromosomes conserved electrophoretic eliminating galactosidase gangliosidosis gm1 hamster hybrids inbred linkage mammals map q21 segment segregating somatic tf transferrin translocations
Tagcloud (Difference) ?		bovine casein catalytic cattle coast composed defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent subunit subunits synteny theileriosis	acy acy1 acylamino aminoacylase aminohydrolase approximate assignment autosomal electrophoretic eliminating galactosidase gangliosidosis gm1 hamster hybrids inbred linkage mammals map q21 segregating tf transferrin translocations
Tagcloud (Intersection) ?		chromosome chromosomes conserved segment somatic