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CSNK2B and LCK
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
CSNK2B
LCK
Description
casein kinase 2 beta
LCK proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Chromatin
Fibrillar Center
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Protein Kinase CK2 Complex
PML Body
PcG Protein Complex
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Pericentriolar Material
Immunological Synapse
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Membrane Raft
Extracellular Exosome
Molecular Function
Chromatin Binding
Protein Serine/threonine Kinase Activity
Signaling Receptor Binding
Protein Binding
Protein Kinase Regulator Activity
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Serine/threonine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Phospholipase Binding
Phosphatidylinositol 3-kinase Binding
ATPase Binding
Protein Antigen Binding
Biological Process
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Wnt Signaling Pathway
Peptidyl-threonine Phosphorylation
Release From Viral Latency
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Activin Receptor Signaling Pathway
Adiponectin-activated Signaling Pathway
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of SMAD Protein Signal Transduction
Endothelial Tube Morphogenesis
Protein-containing Complex Assembly
Symbiont-mediated Disruption Of Host Cell PML Body
Negative Regulation Of Viral Life Cycle
Immune Response-activating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Intracellular Zinc Ion Homeostasis
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Xenobiotic Stimulus
Positive Regulation Of Gene Expression
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Platelet Activation
T Cell Differentiation
T Cell Costimulation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway
T Cell Activation
Gamma-delta T Cell Differentiation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Gamma-delta T Cell Differentiation
Regulation Of Regulatory T Cell Differentiation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Leukocyte Migration
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Multicellular Organismal Process
Regulation Of Lymphocyte Activation
CD27 Signaling Pathway
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Neutrophil degranulation
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity
KEAP1-NFE2L2 pathway
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Maturation of hRSV A proteins
SPOP-mediated proteasomal degradation of PD-L1(CD274)
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Nef Mediated CD4 Down-regulation
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
Co-stimulation by CD28
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
Co-inhibition by CTLA4
Co-inhibition by PD-1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RHOH GTPase cycle
Interleukin-2 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
FLT3 signaling through SRC family kinases
Drugs
ATP
Quercetin
Dasatinib
AP-22408
Staurosporine
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
{4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid
Phosphoaminophosphonic Acid-Adenylate Ester
3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE
5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
Ponatinib
Nintedanib
Fostamatinib
Zanubrutinib
Zotiraciclib
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Cutaneous lupus erythematosus (
25827949
)
Hip circumference adjusted for BMI (
34021172
)
Inflammatory bowel disease (
28067908
)
Malaria (
31844061
)
Systemic lupus erythematosus (
26316170
)
Ulcerative colitis (
28067908
)
Multiple sclerosis (
31604244
)
Interacting Genes
222 interacting genes:
ABHD4
ACTB
ACTL6B
ACTR1B
ACTR5
ACVRL1
ADD1
ADH5
ANGPT2
ANKRD28
AP2M1
APLP1
ARAF
ATF1
ATG101
ATXN3
BAG6
BANP
BCCIP
BHLHE41
BID
BMI1
BRCA1
BTF3
C6orf136
CACNA1A
CALM1
CCDC187
CCNB1
CCNH
CD163
CD81
CDC25B
CDC34
CDK1
CDK20
CDKN1A
CHEK1
CHRNA4
CIC
CIPC
CLOCK
COIL
COL4A2
COPS3
COPS7A
CPNE7
CREB1
CSN1S1
CSN2
CSNK1E
CSNK2A1
CSNK2A2
CST1
CTDP1
CTNNB1
DACT1
DALRD3
DAXX
DELEC1
DENND5A
DNMT1
DPF3
DSCAM
DUX1
DYNLT2B
EIF2S2
EIF5
EIF6
EPS8
ERCC6
ERCC8
ESR1
FAF1
FAM86C1P
FBXL15
FBXL5
FGB
FGF1
FGF2
FIBP
FKBP3
FTH1
FXR1
FXR2
GADD45GIP1
GAMT
GBP2
GLB1
GLIS2
GNB5
GRIN2A
GRIN2B
GRK2
GSK3B
HEXB
HNRNPA2B1
HOXB5
HOXB6
HTRA1
HYPK
IER3IP1
INO80B
INTS11
IRS1
ITSN1
KDM6B
KIF2C
LCK
LEPR
LMO4
LRP5L
LTB4R2
LYN
LYST
MAPK14
MBD4
MDM2
MME
MOXD1
MPP2
NAP1L1
NCF1
NGDN
NMT2
NOLC1
NOTCH3
NPAS2
NRBP1
NRF1
NTAQ1
ODC1
OGA
OGT
PDS5A
PER1
PER2
PFKFB4
PHF11
PIMREG
PIN1
PITPNA
PLXNA3
POT1
PPID
PPP1CA
PPP1CB
PPP1CC
PPP2CA
PPP2R1A
PPP2R1B
PPP2R5D
PPP2R5E
PPP3CC
PRKAB2
PRKCZ
PRNP
PROC
PTPRK
PTTG2
PYROXD2
RAD17
RAD51
RFC1
RNF126
RNF7
RORB
RPA1
RPL13
RPL41
RPL5
RPS6KB1
RRAD
RXRA
SARNP
SDHA
SEC11A
SELENOI
SHMT1
SHMT2
SIMC1
SNX2
SPOUT1
SPSB3
SSB
STAT5A
STAU1
STK16
SUMO2
SYNE4
TCEAL7
TENM1
TFAP2A
TFAP2D
TLE1
TLX3
TNFAIP1
TOP2B
TP53
TP53BP2
TP63
TRIM54
TSEN54
TUBB2B
TWF1
UBE2I
UPF1
USO1
UTP14A
VDAC1
VMA22
VRK3
WDR1
WDR18
WFIKKN1
WWOX
ZNF19
ZNF410
ZNF44
ZNF71
ZNF784
ZNHIT1
142 interacting genes:
ACP1
ADAM15
AJUBA
AR
ARHGAP17
ASB9
AXL
BCAR1
BRCA1
C1QTNF2
CBL
CCR5
CD2
CD247
CD28
CD38
CD3E
CD4
CD44
CD48
CD5
CD55
CD79A
CD79B
CD8A
CDC25C
CDC42
CDC45
CDKAL1
CIMIP2B
CSF2RB
CSF3R
CSK
CSNK2B
CTDSP1
CTLA4
CTNND2
DAPP1
DEF6
DLG1
DOK1
DOK2
DOK3
EGFR
ERBB2
ERBB3
ERBB4
ESR1
ESR2
EZR
FAM174A
FAS
FASLG
FCGR3A
FYN
G3BP1
GAB2
GATA3
GRAP
HSP90AA1
IFNAR1
IKBKG
IL2RB
ITK
JAK3
KHDRBS1
KIR2DL3
KIT
LAT
LAX1
LCP2
LIME1
LZTS2
MAPK1
MAPK3
MAPT
MED28
MET
MS4A1
MUC1
NEDD9
NFKBIA
NFKBID
NOTCH1
NR3C1
PAG1
PAK2
PECAM1
PI4KA
PIK3CA
PIK3R1
PLCG1
PLCG2
PLD2
PRKACA
PRKCA
PRKCD
PRKCQ
PTK2
PTK2B
PTPN11
PTPN22
PTPN6
PTPRC
PTPRF
PTPRH
PXN
RAF1
RASA1
RIN3
RORB
SH2B3
SH2D1A
SH2D2A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SMAD2
SMAD3
SMURF1
SOCS1
SOS1
SQSTM1
STAT1
STAT3
STAT5A
SYK
THY1
TRAT1
TRIM35
TRPV4
TUB
UBAP2
UBE3A
UHRF2
UNC119
VAV1
WAS
WASL
ZAP70
Entrez ID
1460
3932
HPRD ID
00278
01080
Ensembl ID
ENSG00000204435
ENSG00000182866
Uniprot IDs
A0A1U9X7J2
N0E4C7
P67870
A0A0S2Z3Y8
E9PJ92
E9PKQ8
P06239
Q573B4
PDB IDs
1DS5
1JWH
1QF8
3EED
4DGL
4MD7
4MD8
4MD9
4NH1
6Q38
1BHF
1BHH
1CWD
1CWE
1FBZ
1H92
1IJR
1KIK
1LCJ
1LCK
1LKK
1LKL
1Q68
1Q69
1QPC
1QPD
1QPE
1QPJ
1X27
2IIM
2OF2
2OF4
2OFU
2OFV
2OG8
2PL0
2ZM1
2ZM4
2ZYB
3AC1
3AC2
3AC3
3AC4
3AC5
3AC8
3ACJ
3ACK
3AD4
3AD5
3AD6
3B2W
3BRH
3BYM
3BYO
3BYS
3BYU
3KMM
3KXZ
3LCK
3MPM
4C3F
4D8K
5MTM
5MTN
6H6A
6PDJ
8X2P
Enriched GO Terms of Interacting Partners
?
Nucleus
Nucleoplasm
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Cytosol
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of DNA Metabolic Process
Protein Binding
Regulation Of Cell Cycle
Cytoplasm
Macromolecule Metabolic Process
Positive Regulation Of DNA Metabolic Process
DNA Damage Response
Rhythmic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Circadian Rhythm
Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Gene Expression
Chromosome Organization
Regulation Of Transcription By RNA Polymerase II
Response To Light Stimulus
Regulation Of Cell Cycle Process
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Circadian Regulation Of Gene Expression
Nucleic Acid Metabolic Process
Circadian Rhythm
Positive Regulation Of RNA Biosynthetic Process
Regulation Of DNA-templated Transcription
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Programmed Cell Death
Photoperiodism
Negative Regulation Of Metabolic Process
DNA Damage Checkpoint Signaling
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Response To Radiation
Signal Transduction In Response To DNA Damage
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Cellular Response To Oxygen-containing Compound
Cell Cycle Phase Transition
Intracellular Signal Transduction
Signal Transduction
Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Immune Response-activating Signaling Pathway
Activation Of Immune Response
Plasma Membrane
Intracellular Signal Transduction
T Cell Receptor Signaling Pathway
Lymphocyte Activation
Positive Regulation Of Immune Response
Leukocyte Activation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Activation
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Immune Response
Adaptive Immune Response
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Intracellular Signaling Cassette
Regulation Of Cell Activation
Protein Kinase Binding
Regulation Of T Cell Activation
T Cell Activation
Cytokine-mediated Signaling Pathway
Regulation Of MAPK Cascade
Regulation Of Leukocyte Cell-cell Adhesion
B Cell Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Positive Regulation Of Intracellular Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Cellular Component Organization
Regulation Of Multicellular Organismal Process
Negative Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
ERBB Signaling Pathway
Tagcloud
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Tagcloud (Intersection)
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