ADD1 and MAP1LC3B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ADD1	MAP1LC3B
Description		adducin 1	microtubule associated protein 1 light chain 3 beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Membrane Nuclear Body Cell Junction	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Cytosol Cytoskeleton Microtubule Axoneme Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Mitochondrial Membrane
	Molecular Function	RNA Binding Actin Binding Protein Binding Calmodulin Binding Cytoskeletal Anchor Activity Spectrin Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Protein Dimerization Activity Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Ceramide Binding
	Biological Process	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cellular Component Size Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Positive Regulation Of Developmental Process Positive Regulation Of Cellular Component Organization Cellular Response To Calcium Ion Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Adherens Junction Organization Regulation Of Multicellular Organismal Development	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Autophagosome Maturation
Pathways		Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events	Macroautophagy PINK1-PRKN Mediated Mitophagy TBC/RABGAPs Receptor Mediated Mitophagy Pexophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 modulates autophagy KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Coffee consumption (cups per day) ( 31837886) Household income ( 31844048) Household income (MTAG) ( 31844048) Huntington's disease progression ( 28642124) Monocyte percentage of white cells ( 32888494)	General factor of neuroticism ( 30867560) Major depressive disorder ( 22472876) Metabolite levels ( 23823483) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		24 interacting genes: ADD2 AIRIM ATP1A1 CALM1 CASP3 CDK1 CSNK2B GEMIN7 HMG20A HSF2BP HSPH1 ID2 ID3 KLHL42 MAP1LC3B PRKACA PRKCA PRKCD RFX1 ROCK1 SPTA1 SPTB TK1 ZDHHC17	97 interacting genes: AAMP ABTB3 ADD1 ADNP AFTPH AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4C ATG4D ATG7 BAG6 BIRC6 BNIP3 BRD3 BRD9 CAMSAP1 CARS2 CASP8 CCDC50 CCPG1 CCSER2 CDC37 CLTA CUL3 DBI DBN1 DNMT3B DPPA4 EED EPS8 EVA1A FLCN FUNDC1 GORASP2 HYPK IRGQ KBTBD7 KLHL5 KXD1 LUC7L2 MESD MKRN1 MRFAP1 MRTFA MTX1 MYBL2 NCOR1 NEDD4 NEK9 OPTN PCNT PLEKHM1 PRKCZ PRUNE2 RAD1 RAP1GAP RASAL3 RETREG1 RETREG2 RIC1 RIPOR1 RPLP1 SAMM50 SEM1 SEPTIN3 SMARCB1 SNCA SNU13 SNX18 SPAG9 SQSTM1 STK3 STK36 TAF7 TBC1D17 TBC1D25 TBC1D5 TBC1D9 TBC1D9B THAP7 TMOD3 TNIP1 TPPP TRIM21 TRIM25 TRIM32 TTN UPF2 USP10 VHL WDR90
Entrez ID		118	81631
HPRD ID		00036	14358
Ensembl ID		ENSG00000087274	ENSG00000140941
Uniprot IDs		A0A804HL01 P35611	Q658J6 Q9GZQ8
PDB IDs			1V49 2LUE 2N9X 2ZJD 3VTU 3VTV 3VTW 3WAO 3X0W 4WAA 5D94 5DCN 5GMV 5MS2 5MS5 5MS6 5V4K 5W9A 5XAC 5XAD 5XAE 6J04 6LAN 7ELG 7GA8 7GA9 7GAA 7GAB 7GAC 7GAD 7GAE 7GAF 7GAG 7GAH 7GAI 7GAJ 7GAK 7GAL 7GAM 7GAN 7GAO 7GAP 7GAQ 7GAR 7GAS 7GAU 8Q53 8Q7K 8YV6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Actin Filament Polymerization Cytosol DNA Synthesis Involved In Mitotic DNA Replication Peptidyl-threonine Phosphorylation Protein Phosphorylation Actin Filament Capping Phosphorylation Kinase Activity Thymidine Biosynthetic Process Protein Serine/threonine Kinase Activity Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase C Signaling Negative Regulation Of Actin Filament Depolymerization Regulation Of Muscle System Process Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Organization Negative Regulation Of Protein-containing Complex Assembly Thymidine Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Length Spectrin-associated Cytoskeleton Negative Regulation Of Cytoskeleton Organization Protein Kinase Activity Cytoplasm Negative Regulation Of Supramolecular Fiber Organization Spectrin Response To Reactive Oxygen Species ATP Binding Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Nucleocytoplasmic Transport Mitotic Nuclear Membrane Disassembly Regulation Of Actin Cytoskeleton Organization Protein Serine Kinase Activity Pyrimidine Nucleoside Metabolic Process Intracellular Signaling Cassette Regulation Of Actin Filament-based Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Regulation Of Amide Metabolic Process Nuclear Membrane Disassembly Response To Hormone Cell Communication By Electrical Coupling Involved In Cardiac Conduction Membrane Disassembly Positive Regulation Of Macrophage Differentiation Regulation Of Cell Activation Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Depolymerization Protein Modification Process	Autophagy Autophagy Of Mitochondrion Mitophagy Macroautophagy Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Organelle Organization Regulation Of Autophagy Vacuole Organization Organelle Assembly Piecemeal Microautophagy Of The Nucleus Protein-phosphatidylethanolamide Deconjugating Activity Microautophagy Catabolic Process Positive Regulation Of Autophagy Protein Delipidation Aggrephagy Cellular Component Assembly Establishment Of Protein Localization Cytoplasm Substrate Localization To Autophagosome Intracellular Protein Localization Protein Transport Protein Binding Positive Regulation Of Catabolic Process Cytosol Endoplasmic Reticulum-autophagosome Adaptor Activity Cellular Localization Establishment Of Localization In Cell Regulation Of Protein Stability Proteolysis Involved In Protein Catabolic Process Cysteine-type Endopeptidase Activity Regulation Of Cellular Component Organization Response To Mitochondrial Depolarisation Proteolysis Regulation Of Organelle Organization Regulation Of Macroautophagy Protein Monoubiquitination GTPase Activator Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Macroautophagy Phagophore Assembly Site Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Catabolic Process Regulation Of Cell Projection Assembly
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