ADD1 and SPTB

Number of citations of the paper that reports this interaction (PubMedID 8663089)
0

Data Source:
HPRD (in vitro)

		ADD1	SPTB
Description		adducin 1	spectrin beta, erythrocytic
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Membrane Nuclear Body Cell Junction	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Cytoplasmic Side Of Plasma Membrane Cell Surface Spectrin-associated Cytoskeleton Actin Cytoskeleton Cell Junction Cortical Actin Cytoskeleton Protein-containing Complex Cell Projection Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding Actin Binding Protein Binding Calmodulin Binding Cytoskeletal Anchor Activity Spectrin Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Protein Dimerization Activity Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Actin Filament Binding
	Biological Process	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cellular Component Size Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Positive Regulation Of Developmental Process Positive Regulation Of Cellular Component Organization Cellular Response To Calcium Ion Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Adherens Junction Organization Regulation Of Multicellular Organismal Development	Actin Cytoskeleton Organization Synapse Organization Actin Filament Capping Modification Of Postsynaptic Actin Cytoskeleton
Pathways		Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases			Hereditary spherocytosis (SPH) Hereditary elliptocytosis (HE)
GWAS		Coffee consumption (cups per day) ( 31837886) Household income ( 31844048) Household income (MTAG) ( 31844048) Huntington's disease progression ( 28642124) Monocyte percentage of white cells ( 32888494)	Daytime sleep phenotypes ( 27126917) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Pediatric areal bone mineral density (radius) ( 28181694) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Type 2 diabetes ( 31049640)
Interacting Genes		24 interacting genes: ADD2 AIRIM ATP1A1 CALM1 CASP3 CDK1 CSNK2B GEMIN7 HMG20A HSF2BP HSPH1 ID2 ID3 KLHL42 MAP1LC3B PRKACA PRKCA PRKCD RFX1 ROCK1 SPTA1 SPTB TK1 ZDHHC17	18 interacting genes: ACTB ADD1 ANK1 AP1G1 CSRP3 DMTN ENO3 EPB41 MAPT NCAM1 NRIP1 SH2D2A SNAPIN SPTA1 SPTAN1 STAT1 TULP3 YWHAQ
Entrez ID		118	6710
HPRD ID		00036	01686
Ensembl ID		ENSG00000087274	ENSG00000070182
Uniprot IDs		A0A804HL01 P35611	P11277
PDB IDs			1S35 3EDU 3F57 3KBT 3KBU 3LBX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Actin Filament Polymerization Cytosol DNA Synthesis Involved In Mitotic DNA Replication Peptidyl-threonine Phosphorylation Protein Phosphorylation Actin Filament Capping Phosphorylation Kinase Activity Thymidine Biosynthetic Process Protein Serine/threonine Kinase Activity Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase C Signaling Negative Regulation Of Actin Filament Depolymerization Regulation Of Muscle System Process Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Organization Negative Regulation Of Protein-containing Complex Assembly Thymidine Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Length Spectrin-associated Cytoskeleton Negative Regulation Of Cytoskeleton Organization Protein Kinase Activity Cytoplasm Negative Regulation Of Supramolecular Fiber Organization Spectrin Response To Reactive Oxygen Species ATP Binding Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Nucleocytoplasmic Transport Mitotic Nuclear Membrane Disassembly Regulation Of Actin Cytoskeleton Organization Protein Serine Kinase Activity Pyrimidine Nucleoside Metabolic Process Intracellular Signaling Cassette Regulation Of Actin Filament-based Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Regulation Of Amide Metabolic Process Nuclear Membrane Disassembly Response To Hormone Cell Communication By Electrical Coupling Involved In Cardiac Conduction Membrane Disassembly Positive Regulation Of Macrophage Differentiation Regulation Of Cell Activation Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Depolymerization Protein Modification Process	Spectrin-associated Cytoskeleton Cortical Cytoskeleton Spectrin Binding Actin Filament Capping Structural Constituent Of Cytoskeleton Actin Cytoskeleton Organization Actin Binding Negative Regulation Of Actin Filament Depolymerization Actin Filament-based Process Cytosol Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Cytoskeleton Organization Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Regulation Of Cellular Component Size Cytoskeleton Regulation Of Actin Filament Polymerization Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Protein-containing Complex Assembly Organelle Organization Cytoplasm Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Spectrin Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Filament Binding Cell Junction Negative Regulation Of Cellular Component Organization Regulation Of Protein-containing Complex Assembly Axolemma Supramolecular Fiber Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Mesenchymal Cell Differentiation Regulation Of Cytoskeleton Organization Cytoskeletal Anchor Activity Protein Phosphatase 2A Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Protein Localization To Cell Periphery Kinesin Binding Axon Substantia Nigra Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Melanosome Organization Pigment Granule Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?