ADD1 and ATP1A1

Number of citations of the paper that reports this interaction (PubMedID 10516168)
0

Data Source:
HPRD (in vitro)

		ADD1	ATP1A1
Description		adducin 1	ATPase Na+/K+ transporting subunit alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Membrane Nuclear Body Cell Junction	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Axon Organelle Membrane Protein-containing Complex Sperm Flagellum Sarcolemma Melanosome Cell Projection Membrane Raft Photoreceptor Inner Segment Membrane Extracellular Exosome Extracellular Vesicle
	Molecular Function	RNA Binding Actin Binding Protein Binding Calmodulin Binding Cytoskeletal Anchor Activity Spectrin Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Protein Dimerization Activity Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity Phosphatase Activity ATP Hydrolysis Activity Potassium Ion Binding Sodium Ion Binding Transmembrane Transporter Binding Metal Ion Binding Protein Heterodimerization Activity Protein-folding Chaperone Binding Steroid Hormone Binding
	Biological Process	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cellular Component Size Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Positive Regulation Of Developmental Process Positive Regulation Of Cellular Component Organization Cellular Response To Calcium Ion Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Adherens Junction Organization Regulation Of Multicellular Organismal Development	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Osmosensory Signaling Pathway Regulation Of Blood Pressure Response To Xenobiotic Stimulus Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Sodium Ion Homeostasis Relaxation Of Cardiac Muscle Heart Contraction Cellular Response To Steroid Hormone Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Potassium Ion Import Across Plasma Membrane
Pathways		Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Digoxin Acetyldigitoxin Hydroflumethiazide Etacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Ciclopirox Bepridil Potassium cation Aluminium Magnesium cation Digitoxin Almitrine Istaroxime Bisacodyl Magnesium acetate Potassium acetate Potassium sulfate Potassium Magnesium levulinate Magnesium lactate Aluminium phosphate Aluminum acetate Tegoprazan
Diseases
GWAS		Coffee consumption (cups per day) ( 31837886) Household income ( 31844048) Household income (MTAG) ( 31844048) Huntington's disease progression ( 28642124) Monocyte percentage of white cells ( 32888494)	Coffee consumption ( 29367735) HDL cholesterol levels in HIV infection ( 33109212) Hip index ( 34021172) Macular thickness ( 30535121)
Interacting Genes		24 interacting genes: ADD2 AIRIM ATP1A1 CALM1 CASP3 CDK1 CSNK2B GEMIN7 HMG20A HSF2BP HSPH1 ID2 ID3 KLHL42 MAP1LC3B PRKACA PRKCA PRKCD RFX1 ROCK1 SPTA1 SPTB TK1 ZDHHC17	21 interacting genes: A2M ADD1 CEBPA CFL1 EGFR EZH2 FNDC3B FXYD1 FXYD2 FXYD7 GPR35 HGS MAPK1 MAPK3 NDRG1 PRKCA RNF10 SNAPIN TPT1 ZNRF1 ZNRF2
Entrez ID		118	476
HPRD ID		00036	01662
Ensembl ID		ENSG00000087274	ENSG00000163399
Uniprot IDs		A0A804HL01 P35611	P05023
PDB IDs			7E1Z 7E20 7E21
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Actin Filament Polymerization Cytosol DNA Synthesis Involved In Mitotic DNA Replication Peptidyl-threonine Phosphorylation Protein Phosphorylation Actin Filament Capping Phosphorylation Kinase Activity Thymidine Biosynthetic Process Protein Serine/threonine Kinase Activity Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase C Signaling Negative Regulation Of Actin Filament Depolymerization Regulation Of Muscle System Process Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Organization Negative Regulation Of Protein-containing Complex Assembly Thymidine Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Length Spectrin-associated Cytoskeleton Negative Regulation Of Cytoskeleton Organization Protein Kinase Activity Cytoplasm Negative Regulation Of Supramolecular Fiber Organization Spectrin Response To Reactive Oxygen Species ATP Binding Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Nucleocytoplasmic Transport Mitotic Nuclear Membrane Disassembly Regulation Of Actin Cytoskeleton Organization Protein Serine Kinase Activity Pyrimidine Nucleoside Metabolic Process Intracellular Signaling Cassette Regulation Of Actin Filament-based Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Regulation Of Amide Metabolic Process Nuclear Membrane Disassembly Response To Hormone Cell Communication By Electrical Coupling Involved In Cardiac Conduction Membrane Disassembly Positive Regulation Of Macrophage Differentiation Regulation Of Cell Activation Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Depolymerization Protein Modification Process	Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Response To Epidermal Growth Factor Regulation Of Transport Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Autophagosome-lysosome Fusion ERBB2 Signaling Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Transport Interleukin-34-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Sodium Channel Regulator Activity Intracellular Monoatomic Ion Homeostasis Regulation Of Cell Population Proliferation Positive Regulation Of Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Negative Regulation Of Developmental Process Regulation Of Golgi Inheritance Regulation Of Sodium Ion Transmembrane Transport Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Positive Regulation Of Cellular Component Organization Intracellular Chemical Homeostasis Regulation Of Protein Metabolic Process Chemical Homeostasis Positive Regulation Of Cell Motility Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Sodium Ion Transport Positive Regulation Of Locomotion Epidermal Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Sodium:potassium-exchanging ATPase Complex Regulation Of Sodium Ion Transport Homeostatic Process Cellular Homeostasis Caveola ERBB Signaling Pathway Negative Regulation Of Cell Differentiation Focal Adhesion Morphogenesis Of An Epithelial Fold Regulation Of Cellular PH MAP Kinase Activity Regulation Of Golgi Organization
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