ADD1 and CDK1

Number of citations: 36 (PubMedID 24379415)
Data Source: BioGRID (enzymatic study)

		ADD1	CDK1
Name		adducin 1	cyclin dependent kinase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Membrane Nuclear Body Cell Junction	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Membrane Centrosome Spindle Cytosol Cytoskeleton Spindle Microtubule Membrane Midbody Extracellular Exosome Mitotic Spindle Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Cyclin B1-CDK1 Complex
	Molecular Function	RNA Binding Actin Binding Protein Binding Calmodulin Binding Cytoskeletal Anchor Activity Spectrin Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Protein Dimerization Activity Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding Virus Receptor Activity Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity Cyclin Binding Hsp70 Protein Binding Histone Kinase Activity Cyclin-dependent Protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cellular Component Size Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Positive Regulation Of Developmental Process Positive Regulation Of Cellular Component Organization Cellular Response To Calcium Ion Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Adherens Junction Organization Regulation Of Multicellular Organismal Development	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization DNA Replication DNA Repair Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Nuclear Envelope Organization Mitotic Nuclear Membrane Disassembly Mitotic G2 DNA Damage Checkpoint Signaling Centrosome Cycle Pronuclear Fusion Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Schwann Cell Differentiation Response To Amine Response To Activity Cell Migration Protein Deubiquitination Peptidyl-threonine Phosphorylation Chromosome Condensation Epithelial Cell Differentiation Protein Localization To Kinetochore Positive Regulation Of Protein Import Into Nucleus Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Response To Ethanol Positive Regulation Of DNA Replication Regulation Of Embryonic Development Thymidine Biosynthetic Process Response To Cadmium Ion Response To Copper Ion Symbiont Entry Into Host Cell Microtubule Polymerization Fibroblast Proliferation Rhythmic Process Response To Axon Injury Cell Division Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Cilium Disassembly Positive Regulation Of Mitotic Sister Chromatid Segregation Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide ERK1 And ERK2 Cascade Golgi Disassembly DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Protein Localization To Nucleus Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Organization Involved In Mitosis DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Protein Localization To Site Of Double-strand Break Mitotic DNA-templated DNA Replication
Pathways		Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events	MAPK3 (ERK1) activation E2F-enabled inhibition of pre-replication complex formation Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdc20 mediated degradation of Cyclin B Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Depolymerization of the Nuclear Lamina Anchoring of the basal body to the plasma membrane MAPK6/MAPK4 signaling Ovarian tumor domain proteases TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Degradation Mitotic Prophase G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Transcriptional regulation by RUNX2 PKR-mediated signaling
Drugs		None	Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone Seliciclib AT-7519 Fostamatinib Avotaciclib
GWAS		Coffee consumption (cups per day) ( 31837886 ) Household income ( 31844048 ) Household income (MTAG) ( 31844048 ) Huntington's disease progression ( 28642124 ) Monocyte percentage of white cells ( 32888494 )	Cocaine dependence ( 23958962 ) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 31095298 )
Novel Interactors		1 novel interactors: FGFR3	2 novel interactors: IPO13 RFX3
Interacting Genes		24 interacting genes: ADD2 AIRIM ATP1A1 CALM1 CASP3 CDK1 CSNK2B GEMIN7 HMG20A HSF2BP HSPH1 ID2 ID3 KLHL42 MAP1LC3B PRKACA PRKCA PRKCD RFX1 ROCK1 SPTA1 SPTB TK1 ZDHHC17	241 interacting genes: ABL1 ACSL4 ADD1 AKAP12 AKT1 AMPH APLP2 AR ARID4A BARD1 BCL2 BCL2L11 BIRC5 BIRC6 BRCA1 BRCA2 BTG2 BTRC BUB1 CALD1 CCNA1 CCNA2 CCNB1 CCNB1IP1 CCNB2 CCNE1 CCP110 CD8A CDC20 CDC25A CDC25B CDC25C CDCA2 CDCA5 CDK7 CDKN1A CDKN3 CDT1 CEBPA CENPF CEP55 CEP63 CHAF1B CIITA CIP2A CKS2 CNOT7 CREB1 CREM CSN2 CSNK2A1 CSNK2B CTNNB1 CUL4B CUX1 CXCR1 DAB2 DCTN6 DNM2 DTL DUT E2F1 ECT2 EEF1D EEF2K EML3 EPN1 ERCC2 ERCC6L FANCA FANCC FANCG FBXO5 FEN1 FLNA FOXM1 FOXO1 FYN GADD45A GADD45B GADD45G GAS2L3 GATA2 GBF1 GFAP GOLGA2 GORASP1 H1-0 H1-1 H1-3 H1-5 H2AC4 H2BC3 H4C1 HASPIN HJURP HMGA1 HMGA2 HMGB1 HSPA2 HTRA2 ID2 IDH1 IDH2 IL16 IL3RA IQGAP1 ITGB3 ITPR1 JAK3 KAT5 KHDRBS1 KIF11 KIF20B KIF26B KMT2E KRT18 LATS1 LMNA LMNB1 LRRK1 LYN LZTS1 MAP4 MAPK12 MAPT MBP MCM2 MCM4 MDM4 MEF2C MIS18BP1 MISP MKI67 MLKL MLST8 MNDA MYC MYT1 NCAPD2 NCAPD3 NCAPG NCAPH NCL NDE1 NEDD1 NES NHERF1 NONO NPM1 NSFL1C NUP210 PAK6 PBK PCM1 PCNA PIN1 PIP5K1C PITPNM1 PKMYT1 PLEC PML POLA1 POLL PON1 PPP1R12A PPP2R1A PPP2R1B PPP2R2B PPP4R2 PPP4R3A PRC1 PRDX1 PRDX2 PRKAR2A PSRC1 PTCH1 PTMA PTPN1 PTPN2 PTPN6 PTTG1 RAB4A RAB5B RACGAP1 RAD9A RANGAP1 RAP1GAP RB1 RCC1 RELB REPS2 RGCC RPA2 RPS3 RPS6KB1 RRM2 RSF1 RUNX1 RUNX2 SAMHD1 SFN SLBP SOX2 SP1 SPAG5 SQSTM1 SRC SSBP1 STK3 STMN1 STMN2 TERF1 TFDP1 TGFBR2 TK1 TLE1 TMPO TNNC1 TOP2A TP53 TP53BP1 TP73 TPR TSC1 TSPYL2 TUBB UBA1 UBE2A UBE3A UHRF2 USP14 USP16 VHL VIM WAC WEE1 XIAP XPO1 XRCC6 ZBTB16
Entrez ID		118	983
HPRD ID		00036	00302
Ensembl ID		ENSG00000087274	ENSG00000170312
Uniprot IDs		A0A804HL01 P35611	B7Z3D6 I6L9I5 P06493
PDB IDs		Not available	4Y72 4YC3 4YC6 5HQ0 5LQF 6GU2 6GU3 6GU4 6GU6 6GU7 6TWN 7NJ0
GO Terms Enriched among Interactors		Negative Regulation Of Actin Filament Polymerization Cytosol DNA Synthesis Involved In Mitotic DNA Replication Peptidyl-threonine Phosphorylation Protein Phosphorylation Actin Filament Capping Phosphorylation Kinase Activity Thymidine Biosynthetic Process Protein Serine/threonine Kinase Activity Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase C Signaling Negative Regulation Of Actin Filament Depolymerization Regulation Of Muscle System Process Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Organization Negative Regulation Of Protein-containing Complex Assembly Thymidine Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Length Spectrin-associated Cytoskeleton Negative Regulation Of Cytoskeleton Organization Protein Kinase Activity Cytoplasm Negative Regulation Of Supramolecular Fiber Organization Spectrin Response To Reactive Oxygen Species ATP Binding Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Nucleocytoplasmic Transport Mitotic Nuclear Membrane Disassembly Regulation Of Actin Cytoskeleton Organization Protein Serine Kinase Activity Pyrimidine Nucleoside Metabolic Process Intracellular Signaling Cassette Regulation Of Actin Filament-based Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Regulation Of Amide Metabolic Process Nuclear Membrane Disassembly Response To Hormone Cell Communication By Electrical Coupling Involved In Cardiac Conduction Membrane Disassembly Positive Regulation Of Macrophage Differentiation Regulation Of Cell Activation Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Depolymerization Protein Modification Process	Regulation Of Cell Cycle Regulation Of Cell Cycle Process Cell Division Nucleus Cellular Response To Stress Nucleoplasm DNA Damage Response Regulation Of Mitotic Cell Cycle Organelle Organization Cytosol Cytoplasm Regulation Of Cell Cycle Phase Transition Chromosome Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Cell Cycle Phase Transition Intracellular Signal Transduction Positive Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization DNA Metabolic Process Response To Stress Negative Regulation Of Macromolecule Metabolic Process DNA Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Cytoskeleton Regulation Of DNA Metabolic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Cell Cycle Process Positive Regulation Of Apoptotic Process Protein Kinase Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Cell Cycle G2/M Phase Transition Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Signal Transduction G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Component Assembly Negative Regulation Of Mitotic Cell Cycle