ADD1 and HSPH1

Number of citations of the paper that reports this interaction (PubMedID 14733918)
0

Data Source:
HPRD (in vitro, in vivo)

		ADD1	HSPH1
Description		adducin 1	heat shock protein family H (Hsp110) member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Membrane Nuclear Body Cell Junction	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Protein-containing Complex Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	RNA Binding Actin Binding Protein Binding Calmodulin Binding Cytoskeletal Anchor Activity Spectrin Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Protein Dimerization Activity Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Alpha-tubulin Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cellular Component Size Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Positive Regulation Of Developmental Process Positive Regulation Of Cellular Component Organization Cellular Response To Calcium Ion Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Adherens Junction Organization Regulation Of Multicellular Organismal Development	Protein Folding Response To Unfolded Protein Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of NK T Cell Activation
Pathways		Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events	Scavenging by Class F Receptors Scavenging by Class F Receptors Regulation of HSF1-mediated heat shock response
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Coffee consumption (cups per day) ( 31837886) Household income ( 31844048) Household income (MTAG) ( 31844048) Huntington's disease progression ( 28642124) Monocyte percentage of white cells ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		24 interacting genes: ADD2 AIRIM ATP1A1 CALM1 CASP3 CDK1 CSNK2B GEMIN7 HMG20A HSF2BP HSPH1 ID2 ID3 KLHL42 MAP1LC3B PRKACA PRKCA PRKCD RFX1 ROCK1 SPTA1 SPTB TK1 ZDHHC17	20 interacting genes: ADD1 CEBPA CFL1 CHD3 CSNK2A1 CSNK2A2 DYNLRB1 FNDC3B HSPA13 HSPA8 NEDD8 NMI PAFAH1B1 PAFAH1B3 PGK1 PTEN STK39 TUBA4A UBA1 VAV2
Entrez ID		118	10808
HPRD ID		00036	09990
Ensembl ID		ENSG00000087274	ENSG00000120694
Uniprot IDs		A0A804HL01 P35611	A0A0A0MSM0 B4DY72 Q92598
PDB IDs			6GFA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Actin Filament Polymerization Cytosol DNA Synthesis Involved In Mitotic DNA Replication Peptidyl-threonine Phosphorylation Protein Phosphorylation Actin Filament Capping Phosphorylation Kinase Activity Thymidine Biosynthetic Process Protein Serine/threonine Kinase Activity Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase C Signaling Negative Regulation Of Actin Filament Depolymerization Regulation Of Muscle System Process Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Organization Negative Regulation Of Protein-containing Complex Assembly Thymidine Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Length Spectrin-associated Cytoskeleton Negative Regulation Of Cytoskeleton Organization Protein Kinase Activity Cytoplasm Negative Regulation Of Supramolecular Fiber Organization Spectrin Response To Reactive Oxygen Species ATP Binding Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Nucleocytoplasmic Transport Mitotic Nuclear Membrane Disassembly Regulation Of Actin Cytoskeleton Organization Protein Serine Kinase Activity Pyrimidine Nucleoside Metabolic Process Intracellular Signaling Cassette Regulation Of Actin Filament-based Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Regulation Of Amide Metabolic Process Nuclear Membrane Disassembly Response To Hormone Cell Communication By Electrical Coupling Involved In Cardiac Conduction Membrane Disassembly Positive Regulation Of Macrophage Differentiation Regulation Of Cell Activation Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Depolymerization Protein Modification Process	Regulation Of Proteolysis Regulation Of Cell Size Protein Kinase CK2 Complex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Cytoplasm Regulation Of Cellular Component Size Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Size Nucleotide Binding ATP Binding Protein Targeting To Vacuole Involved In Autophagy Microtubule Cytoskeleton Organization Positive Regulation Of Embryonic Development Cellular Response To Stress Microtubule-based Process PML Body PcG Protein Complex Protein Refolding Negative Regulation Of Cellular Component Organization Negative Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Negative Regulation Of Actin Filament Depolymerization Cellular Response To Metal Ion Protein Heterodimerization Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Protein Metabolic Process Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Cell Growth Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Protein Depolymerization Positive Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Cell Projection Organization Positive Regulation Of Protein Localization To Cell Leading Edge Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Chaperone-mediated Autophagy Translocation Complex Disassembly ATP-dependent Protein Folding Chaperone Dynein Intermediate Chain Binding Central Nervous System Neuron Axonogenesis Phosphoglycerate Kinase Activity Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Sodium Ion Import Across Plasma Membrane Response To Stress Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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