ADD1 and ADD2

Number of citations of the paper that reports this interaction (PubMedID 7490111)
0

Data Source:
HPRD (in vivo)

		ADD1	ADD2
Description		adducin 1	adducin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Membrane Nuclear Body Cell Junction	Cytoplasm Cytosol Cytoskeleton Plasma Membrane F-actin Capping Protein Complex Postsynaptic Density Membrane Cytoplasmic Vesicle Plasma Membrane Raft
	Molecular Function	RNA Binding Actin Binding Protein Binding Calmodulin Binding Cytoskeletal Anchor Activity Spectrin Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Protein Dimerization Activity Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Cytoskeletal Anchor Activity Protein Kinase Binding Spectrin Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity Actin Filament Binding
	Biological Process	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cellular Component Size Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Positive Regulation Of Developmental Process Positive Regulation Of Cellular Component Organization Cellular Response To Calcium Ion Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Adherens Junction Organization Regulation Of Multicellular Organismal Development	Synapse Assembly Actin Cytoskeleton Organization Hemopoiesis Leukocyte Migration Leukocyte Tethering Or Rolling Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Protein-containing Complex Assembly
Pathways		Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events	Miscellaneous transport and binding events
Drugs
Diseases
GWAS		Coffee consumption (cups per day) ( 31837886) Household income ( 31844048) Household income (MTAG) ( 31844048) Huntington's disease progression ( 28642124) Monocyte percentage of white cells ( 32888494)	Acne (severe) ( 24927181) Response to esketamine in treatment resistant depression ( 32724131)
Interacting Genes		24 interacting genes: ADD2 AIRIM ATP1A1 CALM1 CASP3 CDK1 CSNK2B GEMIN7 HMG20A HSF2BP HSPH1 ID2 ID3 KLHL42 MAP1LC3B PRKACA PRKCA PRKCD RFX1 ROCK1 SPTA1 SPTB TK1 ZDHHC17	8 interacting genes: ADD1 APP CALM1 FYN PRKACA PRKCD PTPRZ1 RPH3A
Entrez ID		118	119
HPRD ID		00036	00037
Ensembl ID		ENSG00000087274	ENSG00000075340
Uniprot IDs		A0A804HL01 P35611	P35612 Q05DK5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Actin Filament Polymerization Cytosol DNA Synthesis Involved In Mitotic DNA Replication Peptidyl-threonine Phosphorylation Protein Phosphorylation Actin Filament Capping Phosphorylation Kinase Activity Thymidine Biosynthetic Process Protein Serine/threonine Kinase Activity Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase C Signaling Negative Regulation Of Actin Filament Depolymerization Regulation Of Muscle System Process Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Organization Negative Regulation Of Protein-containing Complex Assembly Thymidine Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Length Spectrin-associated Cytoskeleton Negative Regulation Of Cytoskeleton Organization Protein Kinase Activity Cytoplasm Negative Regulation Of Supramolecular Fiber Organization Spectrin Response To Reactive Oxygen Species ATP Binding Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Nucleocytoplasmic Transport Mitotic Nuclear Membrane Disassembly Regulation Of Actin Cytoskeleton Organization Protein Serine Kinase Activity Pyrimidine Nucleoside Metabolic Process Intracellular Signaling Cassette Regulation Of Actin Filament-based Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Regulation Of Amide Metabolic Process Nuclear Membrane Disassembly Response To Hormone Cell Communication By Electrical Coupling Involved In Cardiac Conduction Membrane Disassembly Positive Regulation Of Macrophage Differentiation Regulation Of Cell Activation Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Depolymerization Protein Modification Process	Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Growth Factor Receptor Binding Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Calcium-mediated Signaling Regulation Of Dendritic Spine Maintenance Regulation Of Metal Ion Transport Regulation Of Biological Quality Regulation Of Superoxide Anion Generation Regulation Of Monoatomic Ion Transport Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Transport Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Protein Localization To Nucleus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Fc Receptor Mediated Stimulatory Signaling Pathway Modulation Of Chemical Synaptic Transmission Calcium-mediated Signaling Calcium Channel Complex Cellular Response To Peptide Hormone Stimulus Ephrin Receptor Binding Regulation Of Establishment Of Protein Localization Regulation Of Superoxide Metabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Organization Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Fc-gamma Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Motile Cilium Cell Projection Neuron Projection Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-serine Phosphorylation Positive Regulation Of Protein Transport Membrane Regulation Of Neuron Apoptotic Process Regulation Of Blood Circulation Negative Regulation Of Actin Filament Polymerization Glutamate Receptor Signaling Pathway Learning Or Memory Perinuclear Region Of Cytoplasm Neuron Projection Morphogenesis Cellular Response To Amyloid-beta Sperm Midpiece Cell Projection Morphogenesis
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