ADD1 and ID2

Number of citations of the paper that reports this interaction (PMID 10585876)
18

Data Source:
HPRD (in vitro, in vivo)

		ADD1	ID2
Gene Name		adducin 1 (alpha)	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Dendritic Spine Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Cytoskeleton Protein Complex
	Molecular Function	Actin Binding Structural Molecule Activity Calmodulin Binding Transcription Factor Binding Spectrin Binding T Cell Receptor Binding Protein Homodimerization Activity Poly(A) RNA Binding Protein Heterodimerization Activity Actin Filament Binding	Protein Binding Ion Channel Binding Protein Dimerization Activity
	Biological Process	Cell Morphogenesis In Utero Embryonic Development Cell Volume Homeostasis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Hemoglobin Metabolic Process Actin Cytoskeleton Organization Erythrocyte Differentiation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Binding Multicellular Organism Growth Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Endocytosis Homeostasis Of Number Of Cells Within A Tissue Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Cellular Response To Retinoic Acid	Negative Regulation Of Transcription From RNA Polymerase II Promoter Metanephros Development Natural Killer Cell Differentiation Membranous Septum Morphogenesis Bundle Of His Development Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Regulation Of Lipid Metabolic Process Olfactory Bulb Development Circadian Regulation Of Gene Expression Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Enucleate Erythrocyte Differentiation Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Locomotor Rhythm Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Maturation Peyer's Patch Development Embryonic Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Adipose Tissue Development Mammary Gland Alveolus Development Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Endodermal Digestive Tract Morphogenesis Positive Regulation Of Cell Cycle Arrest Cellular Response To Lithium Ion Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Senescence Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Apoptotic cleavage of cellular proteins IRE1alpha activates chaperones Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS			IgE levels ( 22075330)
Protein-Protein Interactions		21 interactors: ADD2 ATP1A1 CALM1 CASP3 CSNK2B GEMIN7 HMG20A HSPH1 ID2 ID3 MAP1LC3B PRKACA PRKCD RFX1 ROCK1 SMARCC1 SPTA1 SPTAN1 SPTB TK1 ZDHHC17	37 interactors: ADD1 ASB4 CDK2 ELK1 ELK3 ELK4 GATA4 HES1 HSPA5 IFI16 KDM1A LRIF1 MAPK1 MAPK3 MAPK8 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 PAX2 PAX5 PAX8 PPP1CA PRMT6 RB1 RBL1 RBL2 RBM48 SUV39H1 SUV39H2 TCF12 TCF3 TCF4 TSTA3 UNC119
Entrez ID		118	3398
HPRD ID		00036	02664
Ensembl ID		ENSG00000087274	ENSG00000115738
Uniprot IDs		A2A3N8 P35611 Q86XM2	Q02363 Q53T66
PDB IDs			4AYA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Actin Filament Polymerization Response To External Stimulus Negative Regulation Of Protein Polymerization Regulation Of Actin Filament-based Process Regulation Of Binding Nervous System Development Negative Regulation Of Protein Complex Assembly Actin Filament Capping Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Execution Phase Of Apoptosis Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length System Development Negative Regulation Of Protein Complex Disassembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stimulus Regulation Of Cell Activation Regulation Of Protein Depolymerization Neuron Differentiation Generation Of Neurons Developmental Process Regulation Of Cytoskeleton Organization Regulation Of Protein Complex Disassembly Multicellular Organismal Development Immune System Process Neurogenesis Anatomical Structure Development Cellular Metabolic Process Regulation Of Protein Binding Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Chemotaxis Regulation Of Cell Adhesion Activation Of Phospholipase C Activity Anatomical Structure Morphogenesis Regulation Of Cell-cell Adhesion Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Cell Morphogenesis Involved In Differentiation Negative Regulation Of Glial Cell Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cardiac Muscle Contraction Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase Activity	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Muscle Structure Development Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Differentiation Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Muscle Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Organ Development Positive Regulation Of Skeletal Muscle Fiber Development Skeletal Muscle Cell Differentiation Cell Fate Commitment Developmental Process Regulation Of Cellular Process Chromatin Modification Tissue Development Skeletal Muscle Tissue Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Development
Tagcloud ?		arnt2 asked camk2g cstb ctgf downregulated dr1 epas1 globin gna11 hif1a hypoxic il6st khsrp mars multitude neuroglobin neuroprotection ngb o4 ogd pea15 r4 reoxygenation rest spatially temporally tg wt	basic bhlh blackfan broadly compensated competed dba declined defect diamond disrupted downregulate e47 enhancing erythroblasts erythroid globin heb helix heterodimer maturation positively precursors progenitors scf scl sequesters stimulates transfusion
Tagcloud (Difference) ?		arnt2 asked camk2g cstb ctgf downregulated dr1 epas1 gna11 hif1a hypoxic il6st khsrp mars multitude neuroglobin neuroprotection ngb o4 ogd pea15 r4 reoxygenation rest spatially temporally tg wt	basic bhlh blackfan broadly compensated competed dba declined defect diamond disrupted downregulate e47 enhancing erythroblasts erythroid heb helix heterodimer maturation positively precursors progenitors scf scl sequesters stimulates transfusion
Tagcloud (Intersection) ?		globin