ADD1 and ROCK1

Number of citations of the paper that reports this interaction (PMID 10209029)
62

Data Source:
HPRD (in vivo)

		ADD1	ROCK1
Gene Name		adducin 1 (alpha)	Rho-associated, coiled-coil containing protein kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Dendritic Spine Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm	Golgi Membrane Ruffle Centriole Cytosol Cytoskeleton Plasma Membrane Lamellipodium Bleb
	Molecular Function	Actin Binding Structural Molecule Activity Calmodulin Binding Transcription Factor Binding Spectrin Binding T Cell Receptor Binding Protein Homodimerization Activity Poly(A) RNA Binding Protein Heterodimerization Activity Actin Filament Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP-Rho Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis In Utero Embryonic Development Cell Volume Homeostasis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Hemoglobin Metabolic Process Actin Cytoskeleton Organization Erythrocyte Differentiation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Binding Multicellular Organism Growth Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Endocytosis Homeostasis Of Number Of Cells Within A Tissue Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Cellular Response To Retinoic Acid	Apical Constriction Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Axon Guidance Negative Regulation Of Angiogenesis Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Bleb Assembly Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Apoptotic Process Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Leukocyte Tethering Or Rolling Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility
Pathways		Apoptotic cleavage of cellular proteins IRE1alpha activates chaperones Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	Signaling by GPCR Apoptotic cleavage of cellular proteins Axon guidance Semaphorin interactions Apoptotic execution phase VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse GPCR downstream signaling Signaling by VEGF Programmed Cell Death EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs			HYDROXYFASUDIL (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ADD2 ATP1A1 CALM1 CASP3 CSNK2B GEMIN7 HMG20A HSPH1 ID2 ID3 MAP1LC3B PRKACA PRKCD RFX1 ROCK1 SMARCC1 SPTA1 SPTAN1 SPTB TK1 ZDHHC17	32 interactors: ADD1 ARHGAP24 C6orf165 CASP3 CASP7 CDC25A CDC34 CRMP1 DES DPYSL2 EZR FAM124A GFAP IKBKB IRS1 ITSN2 LIMK1 LIMK2 LMO2 MAGEB4 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOC RND3 SMAD2 TSG101 VIM
Entrez ID		118	6093
HPRD ID		00036	03414
Ensembl ID		ENSG00000087274
Uniprot IDs		A2A3N8 P35611 Q86XM2	Q13464
PDB IDs			1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Actin Filament Polymerization Response To External Stimulus Negative Regulation Of Protein Polymerization Regulation Of Actin Filament-based Process Regulation Of Binding Nervous System Development Negative Regulation Of Protein Complex Assembly Actin Filament Capping Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Execution Phase Of Apoptosis Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length System Development Negative Regulation Of Protein Complex Disassembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stimulus Regulation Of Cell Activation Regulation Of Protein Depolymerization Neuron Differentiation Generation Of Neurons Developmental Process Regulation Of Cytoskeleton Organization Regulation Of Protein Complex Disassembly Multicellular Organismal Development Immune System Process Neurogenesis Anatomical Structure Development Cellular Metabolic Process Regulation Of Protein Binding Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Chemotaxis Regulation Of Cell Adhesion Activation Of Phospholipase C Activity Anatomical Structure Morphogenesis Regulation Of Cell-cell Adhesion Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Cell Morphogenesis Involved In Differentiation Negative Regulation Of Glial Cell Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cardiac Muscle Contraction Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase Activity	Regulation Of Cellular Component Organization Cytoskeleton Organization Negative Regulation Of Cell Projection Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Cell Development Regulation Of Cell Projection Organization Cell Differentiation Positive Regulation Of Metabolic Process Epithelium Development Axon Guidance Movement Of Cell Or Subcellular Component Actin Filament-based Process Organelle Organization Regulation Of Cellular Process Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Skeletal Muscle Satellite Cell Migration Axonogenesis Cell Morphogenesis Neuron Projection Development Axon Development Neuron Differentiation System Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neuron Projection Development Cell Projection Organization Response To Stimulus Response To Growth Factor Establishment Of Endothelial Barrier Chemotaxis Regulation Of Metabolic Process Developmental Process Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Neuron Projection Morphogenesis Negative Regulation Of Neuron Projection Development Locomotion Neuron Development Wound Healing, Spreading Of Cells Neurogenesis Negative Regulation Of Ruffle Assembly Membrane To Membrane Docking Tissue Development Bergmann Glial Cell Differentiation Positive Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Multicellular Organismal Development Endothelial Cell Development Positive Regulation Of Actin Filament Bundle Assembly
Tagcloud ?		arnt2 asked camk2g cstb ctgf downregulated dr1 epas1 globin gna11 hif1a hypoxic il6st khsrp mars multitude neuroglobin neuroprotection ngb o4 ogd pea15 r4 reoxygenation rest spatially temporally tg wt	angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory
Tagcloud (Difference) ?		arnt2 asked camk2g cstb ctgf downregulated dr1 epas1 globin gna11 hif1a hypoxic il6st khsrp mars multitude neuroglobin neuroprotection ngb o4 ogd pea15 r4 reoxygenation rest spatially temporally tg wt	angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory
Tagcloud (Intersection) ?