PRKCZ and NCOA3

Number of citations of the paper that reports this interaction (PMID 18313384)
28

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		PRKCZ	NCOA3
Gene Name		protein kinase C, zeta	nuclear receptor coactivator 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Tight Junction Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Cell Leading Edge Filamentous Actin Myelin Sheath Abaxonal Region Axon Hillock Membrane Raft Apical Cortex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Phospholipase Binding Insulin Receptor Substrate Binding Metal Ion Binding 14-3-3 Protein Binding	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Androgen Receptor Binding
	Biological Process	Microtubule Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Long-term Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Cell Migration Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Platelet Activation Negative Regulation Of Protein Complex Assembly Actin Cytoskeleton Reorganization Activation Of Phospholipase D Activity Activation Of Protein Kinase B Activity Positive Regulation Of Interleukin-4 Production Negative Regulation Of Apoptotic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Vesicle Transport Along Microtubule Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Negative Regulation Of Hydrolase Activity Membrane Hyperpolarization Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Protein Localization To Plasma Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Interleukin-5 Secretion Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-10 Secretion	Transcription, DNA-templated Positive Regulation Of Gene Expression Histone Acetylation Androgen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Cellular Response To Hormone Stimulus Multicellular Organism Growth Receptor Transactivation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Developmental Growth Vagina Development Labyrinthine Layer Morphogenesis Mammary Gland Branching Involved In Thelarche Regulation Of RNA Biosynthetic Process
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by VEGF GPVI-mediated activation cascade Platelet activation, signaling and aggregation SMAD4 MH2 Domain Mutants in Cancer	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Height ( 20881960) Reasoning ( 21107309)	Response to treatment for acute lymphoblastic leukemia ( 19176441)
Protein-Protein Interactions		84 interactors: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BTK C1QBP CASP3 CASP6 CASP7 CASP8 CASP9 CCDC115 CDC42 CHAT CSNK2B DAPK3 DENND5A FADD FEZ1 FEZ2 FRS2 FYN GLRX3 GRB14 GRM5 GSK3A GSK3B HABP4 HIST1H1A HIST1H1B HIST3H3 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MARCKS MBP NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UTP14A WWC1 YWHAB YWHAQ YWHAZ ZNF71	77 interactors: ABL1 ANKRD11 AR ARNT2 ATAD2 BMP6 BMP7 BRCA1 BRE CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B HIST3H3 HIST4H4 IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SMARCE1 SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ
Entrez ID		5590	8202
HPRD ID		01504	03570
Ensembl ID		ENSG00000067606	ENSG00000124151
Uniprot IDs		Q05513	Q0IIN7 Q59EE8 Q9Y6Q9
PDB IDs			1KBH 3L3X 3L3Z
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Defense Response Fc Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Signaling Fc-epsilon Receptor Signaling Pathway Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Communication Apoptotic Signaling Pathway Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Death Apoptotic Process Response To Fibroblast Growth Factor Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cell Death Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity	Steroid Hormone Mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Response To Steroid Hormone Response To Lipid Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Lipid Regulation Of Gene Expression Response To Hormone Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Cellular Response To Organic Cyclic Compound Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Gene Expression Negative Regulation Of RNA Biosynthetic Process Signaling Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cell Communication Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process
Tagcloud ?		apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap	acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy meis1 menin mll1 moz myst3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Difference) ?		apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap	acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy meis1 menin mll1 moz myst3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Intersection) ?