PRKCZ and KRT10

Number of citations of the paper that reports this interaction (PMID 11585925)
18

Data Source:
HPRD (in vivo)

		PRKCZ	KRT10
Gene Name		protein kinase C, zeta	keratin 10, type I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Tight Junction Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Cell Leading Edge Filamentous Actin Myelin Sheath Abaxonal Region Axon Hillock Membrane Raft Apical Cortex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Space Nucleus Cytoplasm Intermediate Filament Membrane Keratin Filament Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Phospholipase Binding Insulin Receptor Substrate Binding Metal Ion Binding 14-3-3 Protein Binding	Structural Constituent Of Epidermis
	Biological Process	Microtubule Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Long-term Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Cell Migration Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Platelet Activation Negative Regulation Of Protein Complex Assembly Actin Cytoskeleton Reorganization Activation Of Phospholipase D Activity Activation Of Protein Kinase B Activity Positive Regulation Of Interleukin-4 Production Negative Regulation Of Apoptotic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Vesicle Transport Along Microtubule Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Negative Regulation Of Hydrolase Activity Membrane Hyperpolarization Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Protein Localization To Plasma Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Interleukin-5 Secretion Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-10 Secretion	Keratinocyte Differentiation Cellular Response To Calcium Ion
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by VEGF GPVI-mediated activation cascade Platelet activation, signaling and aggregation SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Height ( 20881960) Reasoning ( 21107309)
Protein-Protein Interactions		84 interactors: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BTK C1QBP CASP3 CASP6 CASP7 CASP8 CASP9 CCDC115 CDC42 CHAT CSNK2B DAPK3 DENND5A FADD FEZ1 FEZ2 FRS2 FYN GLRX3 GRB14 GRM5 GSK3A GSK3B HABP4 HIST1H1A HIST1H1B HIST3H3 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MARCKS MBP NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UTP14A WWC1 YWHAB YWHAQ YWHAZ ZNF71	5 interactors: AKT1 EVPL GLE1 PRKCZ SMAD3
Entrez ID		5590	3858
HPRD ID		01504	01021
Ensembl ID		ENSG00000067606	ENSG00000186395
Uniprot IDs		Q05513	P13645
PDB IDs			3ASW 4F1Z
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Defense Response Fc Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Signaling Fc-epsilon Receptor Signaling Pathway Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Communication Apoptotic Signaling Pathway Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Death Apoptotic Process Response To Fibroblast Growth Factor Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cell Death Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity	Positive Regulation Of Glucose Import Negative Regulation Of Protein Phosphorylation Positive Regulation Of Glucose Transport Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell Adhesion Negative Regulation Of Phosphorylation Regulation Of Glucose Import Epithelial Cell Differentiation Cellular Response To Growth Factor Stimulus Regulation Of Glucose Transport Response To Growth Factor Wound Healing Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Peptidyl-serine Phosphorylation Positive Regulation Of Transforming Growth Factor Beta3 Production Glycogen Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Establishment Of Protein Localization Cell Activation Response To Wounding Positive Regulation Of Transport Osteoblast Differentiation Regulation Of Protein Localization Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-5 Secretion Positive Regulation Of Cell Differentiation Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cell-substrate Adhesion Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Interleukin-10 Secretion Evasion Or Tolerance Of Host Defenses By Virus Response To Transforming Growth Factor Beta Negative Regulation Of Cell Death Platelet Activation Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of T Cell Activation Cellular Response To Insulin Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap	ceph d17s181 d17s183 d17s190 d17s250 d17s507 d17s508 d17s509 d17s518 d17s579 d17s78 d17s791 d17s797 d17s80 d17s800 d17s806 d17s810 d17s855 d17s856 d17s857 d17s858 d17s859 edh17b epb3 gp3a hox2b kindreds ppy thra1
Tagcloud (Difference) ?		apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap	ceph d17s181 d17s183 d17s190 d17s250 d17s507 d17s508 d17s509 d17s518 d17s579 d17s78 d17s791 d17s797 d17s80 d17s800 d17s806 d17s810 d17s855 d17s856 d17s857 d17s858 d17s859 edh17b epb3 gp3a hox2b kindreds ppy thra1
Tagcloud (Intersection) ?