PRKCZ and BLVRA

Number of citations: 0 (PubMedID 17639074)
Data Source: BioGRID (affinity chromatography technology, pull down)

		PRKCZ	BLVRA
Name		protein kinase C zeta	biliverdin reductase A
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Cell Cortex Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Vesicle Myelin Sheath Abaxonal Region Ciliary Basal Body Axon Hillock Apical Cortex Extracellular Exosome Tight Junction Anchoring Junction PAR Polarity Complex	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Insulin Receptor Substrate Binding Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Biliverdin Reductase [NAD(P)H] Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding Biliberdin Reductase (NADH) Activity Biliverdin Reductase (NADPH) Activity
	Biological Process	Microtubule Cytoskeleton Organization Protein Phosphorylation Inflammatory Response Signal Transduction Establishment Of Cell Polarity Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of T-helper 2 Cell Cytokine Production	Fatty Acid Metabolic Process Triglyceride Metabolic Process Chemotaxis Inflammatory Response Response To Oxidative Stress Gene Expression Response To Food Response To Lipopolysaccharide Lipid Oxidation Complement Component C5a Signaling Pathway Heme Catabolic Process Pigment Metabolic Process Sensory Perception Of Itch Response To Cyclosporin A
Pathways		GPVI-mediated activation cascade TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ	Heme degradation Cytoprotection by HMOX1
Drugs		Tamoxifen Staurosporine Dequalinium Benzoyl peroxide	NADH
GWAS		Body mass index ( 26426971 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) General risk tolerance (MTAG) ( 30643258 ) Height ( 20881960 ) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Mean corpuscular volume ( 32888494 ) Peak insulin response ( 28490609 )
Novel Interactors		2 novel interactors: C5 MTHFR	1 novel interactors: AGPS
Interacting Genes		91 interacting genes: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BLVRA BTK C1QBP CASP3 CASP6 CASP7 CASP8 CASP9 CDC42 CHAT CREBBP CSNK2B DAPK3 DENND5A EGFR FADD FEZ1 FEZ2 FRS2 FYN GABARAP GLRX3 GRB14 GRM5 GSK3A GSK3B H1-1 H1-5 HABP4 HDAC6 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP1LC3B MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MAPT MBP NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PIAS4 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UBC UTP14A VMA22 WWC1 YWHAB YWHAQ YWHAZ ZNF71	5 interacting genes: AKT1 AKT2 LNX1 PRKCB PRKCZ
Entrez ID		5590	644
HPRD ID		01504	11229
Ensembl ID		ENSG00000067606	ENSG00000106605
Uniprot IDs		Q05513	A0A140VJF4 P53004
PDB IDs		Not available	2H63
GO Terms Enriched among Interactors		Cytosol Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Cellular Localization Enzyme-linked Receptor Protein Signaling Pathway Insulin Receptor Signaling Pathway Protein Kinase Activity Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization Positive Regulation Of Cell Migration Phosphorylation Regulation Of Cell-cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Motility Response To Lipid Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Regulation Of Immune System Process Positive Regulation Of Locomotion Regulation Of Cell Migration Activation Of Immune Response Regulation Of Locomotion Kinase Activity Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Signal Transduction Response To Stress	Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Transferase Activity Regulation Of D-glucose Transmembrane Transport Protein Serine Kinase Activity Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Cellular Response To Insulin Stimulus Protein Serine/threonine Kinase Activity Negative Regulation Of Transmembrane Transport Negative Regulation Of PERK-mediated Unfolded Protein Response Mammary Gland Epithelial Cell Differentiation Glycogen Biosynthetic Process Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Fatty Acid Beta-oxidation Myelin Maintenance Positive Regulation Of Glycogen Biosynthetic Process Protein Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Response To Insulin Cell Cortex Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Peptide Hormone Stimulus Kinase Activity Protein Localization To Plasma Membrane Polysaccharide Biosynthetic Process Protein Modification Process Protein Localization To Cell Periphery Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Transport Regulation Of Fatty Acid Oxidation Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Negative Regulation Of Lipid Transport Regulation Of Glycogen Metabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Glucose Metabolic Process Response To Peptide Hormone Protein Localization To Membrane Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Hormone Stimulus Protein Phosphorylation Regulation Of D-glucose Import Regulation Of Lipid Catabolic Process Glycogen Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration