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PRKCZ and PRG2
Number of citations of the paper that reports this interaction (PMID
9748166
)
196
Data Source:
HPRD
(in vitro)
PRKCZ
PRG2
Gene Name
protein kinase C, zeta
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Envelope
Cytoplasm
Endosome
Microtubule Organizing Center
Cytosol
Plasma Membrane
Cell-cell Junction
Tight Junction
Membrane
Apical Plasma Membrane
Nuclear Matrix
Cell Junction
Cell Leading Edge
Filamentous Actin
Myelin Sheath Abaxonal Region
Axon Hillock
Membrane Raft
Apical Cortex
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Extracellular Region
Transport Vesicle
Extracellular Vesicular Exosome
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Protein Binding
ATP Binding
Potassium Channel Regulator Activity
Protein Kinase Binding
Protein Domain Specific Binding
Phospholipase Binding
Insulin Receptor Substrate Binding
Metal Ion Binding
14-3-3 Protein Binding
Heparin Binding
Carbohydrate Binding
Biological Process
Microtubule Cytoskeleton Organization
Positive Regulation Of Cell-matrix Adhesion
Protein Phosphorylation
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Blood Coagulation
Long-term Memory
Positive Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Cell Migration
Peptidyl-serine Phosphorylation
Establishment Of Cell Polarity
Platelet Activation
Negative Regulation Of Protein Complex Assembly
Actin Cytoskeleton Reorganization
Activation Of Phospholipase D Activity
Activation Of Protein Kinase B Activity
Positive Regulation Of Interleukin-4 Production
Negative Regulation Of Apoptotic Process
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Insulin Receptor Signaling Pathway
Vesicle Transport Along Microtubule
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Heterooligomerization
Negative Regulation Of Hydrolase Activity
Membrane Hyperpolarization
Long-term Synaptic Potentiation
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Protein Localization To Plasma Membrane
Neuron Projection Extension
Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Positive Regulation Of T-helper 2 Cell Cytokine Production
Positive Regulation Of Interleukin-5 Secretion
Positive Regulation Of Interleukin-13 Secretion
Positive Regulation Of Interleukin-10 Secretion
Defense Response To Nematode
Immune Response
Negative Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-4 Production
Defense Response To Bacterium
Pathways
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by VEGF
GPVI-mediated activation cascade
Platelet activation, signaling and aggregation
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Height (
20881960
)
Reasoning (
21107309
)
Crohn's disease (
22412388
)
Protein-Protein Interactions
84 interactors:
ADAP1
ADCY5
AFAP1
AKT1
AKT3
BTK
C1QBP
CASP3
CASP6
CASP7
CASP8
CASP9
CCDC115
CDC42
CHAT
CSNK2B
DAPK3
DENND5A
FADD
FEZ1
FEZ2
FRS2
FYN
GLRX3
GRB14
GRM5
GSK3A
GSK3B
HABP4
HIST1H1A
HIST1H1B
HIST3H3
HRAS
IKBKB
IL4R
IRAK1
IRS1
IRS4
JAK1
KRT10
LRRK2
MAP2K1
MAP2K5
MAPK1
MAPK3
MAPK7
MARCKS
MBP
NCF1
NCL
NCOA3
NFATC2
NMT2
NUMB
PARD6A
PARD6B
PARD6G
PAWR
PDLIM7
PDPK1
PEBP1
PPP1R14A
PPP3CA
PRG2
PRKCA
PRKCD
PSEN1
RAF1
RELA
RHOA
SLC39A1
SP1
SQSTM1
SRC
STAT6
STUB1
TIAM1
TRAF6
UTP14A
WWC1
YWHAB
YWHAQ
YWHAZ
ZNF71
7 interactors:
AGT
AKT1
CHD3
CSF2
PAPPA
PRKCZ
RBM48
Entrez ID
5590
5553
HPRD ID
01504
09283
Ensembl ID
ENSG00000067606
Uniprot IDs
Q05513
A6XMW0
P13727
PDB IDs
1H8U
2BRS
Enriched GO Terms of Interacting Partners
?
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Innate Immune Response
Immune Response
Immune Response-regulating Signaling Pathway
Regulation Of Signaling
Regulation Of Signal Transduction
Defense Response
Fc Receptor Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Organic Substance
Regulation Of Immune Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Immune System Process
Positive Regulation Of Signal Transduction
Regulation Of Immune System Process
Signaling
Fc-epsilon Receptor Signaling Pathway
Signal Transduction
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Communication
Apoptotic Signaling Pathway
Response To Organic Substance
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cell Death
Cellular Response To Fibroblast Growth Factor Stimulus
Death
Apoptotic Process
Response To Fibroblast Growth Factor
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Programmed Cell Death
Regulation Of Apoptotic Process
Cellular Response To Stimulus
Regulation Of Cell Death
Positive Regulation Of Metabolic Process
Response To Stress
Regulation Of Protein Metabolic Process
Response To External Stimulus
Regulation Of Intracellular Signal Transduction
Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Regulation Of Cellular Amino Acid Metabolic Process
Regulation Of Cellular Ketone Metabolic Process
Cell Activation
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Peptidyl-tyrosine Phosphorylation
Female Pregnancy
Positive Regulation Of Cell Proliferation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Modification Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Glucose Import
Positive Regulation Of Oxidoreductase Activity
Negative Regulation Of Cell Death
Positive Regulation Of Glucose Transport
Positive Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Regulation Of Macrophage Derived Foam Cell Differentiation
Regulation Of Protein Phosphorylation
Negative Regulation Of Ion Transmembrane Transport
Negative Regulation Of Signal Transduction
Positive Regulation Of Cytokine Production
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Transmembrane Transport
Regulation Of Glucose Import
Positive Regulation Of Endothelial Cell Migration
Regulation Of Vasoconstriction
Negative Regulation Of Signaling
Negative Regulation Of Hydrolase Activity
Regulation Of Nitric Oxide Biosynthetic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Lipid Biosynthetic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Reactive Oxygen Species Biosynthetic Process
Regulation Of Sodium Ion Transport
Positive Regulation Of Signal Transduction
Positive Regulation Of Phospholipase Activity
Regulation Of Phosphorylation
Reproductive Process
Cellular Response To Mechanical Stimulus
Positive Regulation Of Protein Kinase Activity
Regulation Of Phospholipase Activity
Regulation Of Oxidoreductase Activity
Developmental Cell Growth
Positive Regulation Of Peptidyl-serine Phosphorylation
Tagcloud
?
apical
blastocyst
cdx2
compaction
dampened
derives
erm
gtpases
hippo
icm
lats1
lineages
llgl1
nanog
outer
pard6b
phosphorylating
polarity
polarization
rho
rock
scrib
segregation
specification
specifying
te
trophectoderm
tyrosinated
yap
Tagcloud (Difference)
?
apical
blastocyst
cdx2
compaction
dampened
derives
erm
gtpases
hippo
icm
lats1
lineages
llgl1
nanog
outer
pard6b
phosphorylating
polarity
polarization
rho
rock
scrib
segregation
specification
specifying
te
trophectoderm
tyrosinated
yap
Tagcloud (Intersection)
?