PRKCZ and PRG2

Number of citations of the paper that reports this interaction (PubMedID 11222751)
39

Data Source:
HPRD (in vitro)

		PRKCZ	PRG2
Description		protein kinase C zeta	proteoglycan 2, pro eosinophil major basic protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Cell Cortex Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Vesicle Myelin Sheath Abaxonal Region Ciliary Basal Body Axon Hillock Apical Cortex Extracellular Exosome Tight Junction Anchoring Junction PAR Polarity Complex	Extracellular Region Transport Vesicle Extracellular Matrix Cytoplasmic Vesicle Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Insulin Receptor Substrate Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding
	Biological Process	Microtubule Cytoskeleton Organization Protein Phosphorylation Inflammatory Response Signal Transduction Establishment Of Cell Polarity Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of T-helper 2 Cell Cytokine Production	Defense Response To Nematode Immune System Process Immune Response Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Defense Response To Bacterium
Pathways		GPVI-mediated activation cascade TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ	Neutrophil degranulation
Drugs		Tamoxifen Staurosporine Dequalinium Benzoyl peroxide	Sargramostim Chymopapain
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Height ( 20881960) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Crohn's disease ( 22412388) Glucose homeostasis traits ( 25524916)
Interacting Genes		91 interacting genes: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BLVRA BTK C1QBP CASP3 CASP6 CASP7 CASP8 CASP9 CDC42 CHAT CREBBP CSNK2B DAPK3 DENND5A EGFR FADD FEZ1 FEZ2 FRS2 FYN GABARAP GLRX3 GRB14 GRM5 GSK3A GSK3B H1-1 H1-5 HABP4 HDAC6 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP1LC3B MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MAPT MBP NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PIAS4 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UBC UTP14A VMA22 WWC1 YWHAB YWHAQ YWHAZ ZNF71	7 interacting genes: AGT AKT1 CHD3 CSF2 PAPPA PRKCZ RBM48
Entrez ID		5590	5553
HPRD ID		01504	09283
Ensembl ID		ENSG00000067606	ENSG00000186652
Uniprot IDs		Q05513	P13727
PDB IDs			1H8U 2BRS 4QXX 7Y5N 8HGG 9DKZ
Enriched GO Terms of Interacting Partners?		Cytosol Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Cellular Localization Enzyme-linked Receptor Protein Signaling Pathway Insulin Receptor Signaling Pathway Protein Kinase Activity Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization Positive Regulation Of Cell Migration Phosphorylation Regulation Of Cell-cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Motility Response To Lipid Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Regulation Of Immune System Process Positive Regulation Of Locomotion Regulation Of Cell Migration Activation Of Immune Response Regulation Of Locomotion Kinase Activity Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Signal Transduction Response To Stress	Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Differentiation Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cholesterol Metabolic Process Response To Peptide Hormone Positive Regulation Of Cell Differentiation Regulation Of Sodium Ion Transport Regulation Of Apoptotic Signaling Pathway Regulation Of TRNA Methylation Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Cytokine Production Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Membrane Potential Response To Hormone Renin-angiotensin Regulation Of Aldosterone Production Negative Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Growth Factor Activity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Developmental Process Positive Regulation Of Endothelial Cell Migration Regulation Of Lipid Transport Positive Regulation Of Membrane Hyperpolarization Regulation Of Programmed Cell Death Positive Regulation Of Locomotion Positive Regulation Of Lipid Metabolic Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Renal Output By Angiotensin Negative Regulation Of Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process Type 2 Angiotensin Receptor Binding Negative Regulation Of Transmembrane Transport Regulation Of Steroid Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Organelle Assembly
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