PRKCZ and ADCY5

Number of citations of the paper that reports this interaction (PMID 8206971)
25

Data Source:
HPRD (in vitro)

		PRKCZ	ADCY5
Gene Name		protein kinase C, zeta	adenylate cyclase 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Tight Junction Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Cell Leading Edge Filamentous Actin Myelin Sheath Abaxonal Region Axon Hillock Membrane Raft Apical Cortex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane Primary Cilium
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Phospholipase Binding Insulin Receptor Substrate Binding Metal Ion Binding 14-3-3 Protein Binding	Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Microtubule Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Long-term Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Cell Migration Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Platelet Activation Negative Regulation Of Protein Complex Assembly Actin Cytoskeleton Reorganization Activation Of Phospholipase D Activity Activation Of Protein Kinase B Activity Positive Regulation Of Interleukin-4 Production Negative Regulation Of Apoptotic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Vesicle Transport Along Microtubule Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Negative Regulation Of Hydrolase Activity Membrane Hyperpolarization Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Protein Localization To Plasma Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Interleukin-5 Secretion Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-10 Secretion	Adenosine Receptor Signaling Pathway Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Locomotory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Neuromuscular Process Controlling Balance Transmembrane Transport Cellular Response To Glucagon Stimulus
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by VEGF GPVI-mediated activation cascade Platelet activation, signaling and aggregation SMAD4 MH2 Domain Mutants in Cancer	Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Phospholipase C-mediated cascade Integration of energy metabolism Signaling by FGFR in disease Activation of GABAB receptors G alpha (s) signalling events Signaling by EGFRvIII in Cancer Adenylate cyclase activating pathway PLCG1 events in ERBB2 signaling DAP12 signaling G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport EGFR interacts with phospholipase C-gamma Adrenaline,noradrenaline inhibits insulin secretion Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB GPCR downstream signaling Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer PKA activation Transmission across Chemical Synapses DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Innate Immune System GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway Signaling by Hedgehog PLC-gamma1 signalling
Drugs
Diseases
GWAS		Height ( 20881960) Reasoning ( 21107309)	Birth weight ( 23202124 20372150) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Obesity-related traits ( 23251661) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 22693455)
Protein-Protein Interactions		84 interactors: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BTK C1QBP CASP3 CASP6 CASP7 CASP8 CASP9 CCDC115 CDC42 CHAT CSNK2B DAPK3 DENND5A FADD FEZ1 FEZ2 FRS2 FYN GLRX3 GRB14 GRM5 GSK3A GSK3B HABP4 HIST1H1A HIST1H1B HIST3H3 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MARCKS MBP NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UTP14A WWC1 YWHAB YWHAQ YWHAZ ZNF71	7 interactors: ADCY2 GNAI1 GNAS PRKACA PRKCA PRKCZ RGS2
Entrez ID		5590	111
HPRD ID		01504	08973
Ensembl ID		ENSG00000067606	ENSG00000173175
Uniprot IDs		Q05513	B3KWA8 B7Z2C7 O95622
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Defense Response Fc Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Signaling Fc-epsilon Receptor Signaling Pathway Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Communication Apoptotic Signaling Pathway Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Death Apoptotic Process Response To Fibroblast Growth Factor Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cell Death Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity	Regulation Of Phospholipase Activity Platelet Activation Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Energy Reserve Metabolic Process Blood Coagulation Hemostasis Positive Regulation Of Hydrolase Activity Response To Peptide Hormone Renal Water Homeostasis Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Response To Peptide Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Synaptic Transmission Water Transport Histone H3-T6 Phosphorylation Wound Healing Fluid Transport Positive Regulation Of Lyase Activity Positive Regulation Of Myeloid Leukocyte Differentiation Multicellular Organismal Water Homeostasis Activation Of Phospholipase C Activity Response To Glucagon Cell Activation Regulation Of Phosphorus Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Response To Wounding Positive Regulation Of Phospholipase C Activity Regulation Of Glucose Import Regulation Of Adenylate Cyclase Activity Positive Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Water Homeostasis Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Kinase Activity Positive Regulation Of CAMP Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Response To Organonitrogen Compound Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Peptide Negative Regulation Of Protein Phosphorylation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of MAP Kinase Activity
Tagcloud ?		apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap	acts dephosphorylating downregulating enhancing extend extends facilitated facilitating foxo3 fractions hif1alpha irs1 lc3b lifespan longevity mir mkp7 mtor pleiotropically pras40 promoted repressed repression rgs2 senescence ser2248 thr246 translocated upregulating
Tagcloud (Difference) ?		apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap	acts dephosphorylating downregulating enhancing extend extends facilitated facilitating foxo3 fractions hif1alpha irs1 lc3b lifespan longevity mir mkp7 mtor pleiotropically pras40 promoted repressed repression rgs2 senescence ser2248 thr246 translocated upregulating
Tagcloud (Intersection) ?