Wiki-Pi
About
Search
People
Updates
Search
PRKCZ and IKBKB
Number of citations of the paper that reports this interaction (PubMedID
10779355
)
42
Data Source:
HPRD
(in vitro)
PRKCZ
IKBKB
Description
protein kinase C zeta
inhibitor of nuclear factor kappa B kinase subunit beta
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Cytoplasm
Endosome
Microtubule Organizing Center
Cytosol
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Cilium
Cell Cortex
Membrane
Apical Plasma Membrane
Nuclear Matrix
Cell Junction
Vesicle
Myelin Sheath Abaxonal Region
Ciliary Basal Body
Axon Hillock
Apical Cortex
Extracellular Exosome
Tight Junction
Anchoring Junction
PAR Polarity Complex
Nucleus
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
Membrane
CD40 Receptor Complex
Membrane Raft
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Insulin Receptor Substrate Binding
Metal Ion Binding
Protein Serine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Scaffold Protein Binding
Protein Serine Kinase Activity
Transferrin Receptor Binding
Biological Process
Microtubule Cytoskeleton Organization
Protein Phosphorylation
Inflammatory Response
Signal Transduction
Establishment Of Cell Polarity
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Cellular Response To Insulin Stimulus
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of T-helper 2 Cell Differentiation
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Long-term Synaptic Potentiation
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Localization To Plasma Membrane
Neuron Projection Extension
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of T-helper 2 Cell Cytokine Production
Protein Polyubiquitination
Pattern Recognition Receptor Signaling Pathway
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Protein Maturation
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Protein Localization To Plasma Membrane
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Pathways
GPVI-mediated activation cascade
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferation
RHO GTPases Activate NADPH Oxidases
Estrogen-stimulated signaling through PRKCZ
Estrogen-stimulated signaling through PRKCZ
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Drugs
Tamoxifen
Staurosporine
Dequalinium
Benzoyl peroxide
Mesalazine
Acetylsalicylic acid
Auranofin
Arsenic trioxide
MLN0415
Acetylcysteine
Ertiprotafib
Fostamatinib
Diseases
GWAS
Body mass index (
26426971
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
General risk tolerance (MTAG) (
30643258
)
Height (
20881960
)
Response to antipsychotic treatment in schizophrenia (reasoning) (
21107309
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
91 interacting genes:
ADAP1
ADCY5
AFAP1
AKT1
AKT3
BLVRA
BTK
C1QBP
CASP3
CASP6
CASP7
CASP8
CASP9
CDC42
CHAT
CREBBP
CSNK2B
DAPK3
DENND5A
EGFR
FADD
FEZ1
FEZ2
FRS2
FYN
GABARAP
GLRX3
GRB14
GRM5
GSK3A
GSK3B
H1-1
H1-5
HABP4
HDAC6
HRAS
IKBKB
IL4R
IRAK1
IRS1
IRS4
JAK1
KRT10
LRRK2
MAP1LC3B
MAP2K1
MAP2K5
MAPK1
MAPK3
MAPK7
MAPT
MBP
NCF1
NCL
NCOA3
NFATC2
NMT2
NUMB
PARD6A
PARD6B
PARD6G
PAWR
PDLIM7
PDPK1
PEBP1
PIAS4
PPP1R14A
PPP3CA
PRG2
PRKCA
PRKCD
PSEN1
RAF1
RELA
RHOA
SLC39A1
SP1
SQSTM1
SRC
STAT6
STUB1
TIAM1
TRAF6
UBC
UTP14A
VMA22
WWC1
YWHAB
YWHAQ
YWHAZ
ZNF71
91 interacting genes:
ACVR1
AKT1
AURKA
BTRC
CASP8
CCAR2
CDC37
CFLAR
CHUK
COPS3
COPS4
COPS5
CSF2RA
CSF2RB
CTNNB1
CUEDC2
E2F4
EIF2AK2
EIF2AK3
ELP1
FAF1
FANCA
FOXO3
GLI1
HMGCL
HSP90AA1
HSP90AB1
HTT
IKBKG
IRS1
JUN
KLHL21
MAP3K1
MAP3K11
MAP3K13
MAP3K14
MAP3K3
MAP3K7
MAVS
MTDH
MYC
NAA20
NCOA3
NEDD4L
NFKB1
NFKB2
NFKBIA
NFKBIB
NR2C2
PEBP1
PELI1
PLK1
PPARG
PPM1B
PPP2R3C
PRKCA
PRKCB
PRKCD
PRKCE
PRKCQ
PRKCZ
PRKDC
RELA
RICTOR
ROCK1
SAMHD1
SASH1
SQSTM1
SRC
STAP2
TAB2
TANK
TBK1
TFAP2C
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TP73
TRAF1
TRAF2
TRAF3IP2
TRIM21
TRIM27
TRPC4AP
TSC1
TWIST1
UBB
UBC
VHL
YWHAB
Entrez ID
5590
3551
HPRD ID
01504
04462
Ensembl ID
ENSG00000067606
ENSG00000104365
Uniprot IDs
Q05513
A0A499FJS7
G3V105
O14920
PDB IDs
3BRT
3BRV
4E3C
4KIK
8OMV
Enriched GO Terms of Interacting Partners
?
Cytosol
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Signal Transduction
Signal Transduction
Intracellular Signaling Cassette
Regulation Of Intracellular Signal Transduction
Cytoplasm
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signaling
Negative Regulation Of Signal Transduction
Regulation Of Apoptotic Process
Regulation Of Multicellular Organismal Process
Regulation Of Programmed Cell Death
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Positive Regulation Of Signal Transduction
Regulation Of Cellular Localization
Enzyme-linked Receptor Protein Signaling Pathway
Insulin Receptor Signaling Pathway
Protein Kinase Activity
Protein Phosphorylation
Regulation Of Protein Metabolic Process
Positive Regulation Of Immune System Process
Regulation Of Cell Adhesion
Regulation Of Immune Response
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Localization
Positive Regulation Of Cell Migration
Phosphorylation
Regulation Of Cell-cell Adhesion
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Motility
Response To Lipid
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Oxygen-containing Compound
Regulation Of Immune System Process
Positive Regulation Of Locomotion
Regulation Of Cell Migration
Activation Of Immune Response
Regulation Of Locomotion
Kinase Activity
Apoptotic Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Response To Stress
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Intracellular Signal Transduction
Cytosol
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
Signal Transduction
Protein Modification Process
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Protein Serine/threonine Kinase Activity
Response To Stress
Intracellular Signaling Cassette
Macromolecule Metabolic Process
Protein Kinase Activity
Ubiquitin Protein Ligase Binding
Enzyme Binding
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Protein Modification Process
Protein Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Post-translational Protein Modification
Regulation Of Immune Response
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Regulation Of Apoptotic Signaling Pathway
Regulation Of Immune System Process
Cell Surface Receptor Signaling Pathway
Protein Serine Kinase Activity
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?