PRDX1 and SESN2

Number of citations of the paper that reports this interaction (PMID 15105503)
135

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PRDX1	SESN2
Gene Name		peroxiredoxin 1	sestrin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nuclear Euchromatin Nucleolus Cytoplasm Mitochondrial Matrix Peroxisomal Matrix Cytosol Melanosome Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Heme Binding Protein Homodimerization Activity Poly(A) RNA Binding	Protein Binding
	Biological Process	Response To Reactive Oxygen Species Skeletal System Development Retina Homeostasis Cell Proliferation Removal Of Superoxide Radicals Regulation Of Stress-activated MAPK Cascade Erythrocyte Homeostasis Natural Killer Cell Mediated Cytotoxicity Regulation Of NF-kappaB Import Into Nucleus Hydrogen Peroxide Catabolic Process Oxidation-reduction Process	Fatty Acid Beta-oxidation Autophagy Response To Glucose Mitochondrial DNA Metabolic Process Response To Insulin Protein Kinase B Signaling Glucose Import Triglyceride Homeostasis Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Regulation Of Response To Reactive Oxygen Species Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ABL1 ADH5 BTRC CALM1 CLEC4G EGFR GAPDH IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ	3 interactors: MDM2 PRDX1 ULK1
Entrez ID		5052	83667
HPRD ID		01458	06378
Ensembl ID		ENSG00000117450	ENSG00000130766
Uniprot IDs		Q06830	P58004
PDB IDs		2RII 3HY2
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Response To Organic Substance Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Regulation Of Oxidoreductase Activity Positive Regulation Of Apoptotic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Response To Stimulus Positive Regulation Of Cell Death Regulation Of Phospholipase Activity Apoptotic Process Programmed Cell Death Intracellular Signal Transduction Cellular Response To Organic Substance Cell Death Death Regulation Of Response To Reactive Oxygen Species Regulation Of Cellular Ketone Metabolic Process Peptidyl-cysteine S-nitrosylation Innate Immune Response Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Oxidoreductase Activity Response To Lipid Regulation Of Protein Stability Response To Lipopolysaccharide Developmental Process Positive Regulation Of Signal Transduction Response To Molecule Of Bacterial Origin Cellular Response To Growth Factor Stimulus Type I Interferon Biosynthetic Process Immune Response Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Response To Growth Factor Regulation Of Cell Cycle Cellular Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Organic Cyclic Compound Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Phosphorylation Cell Cycle Process Response To Fibroblast Growth Factor	Cellular Response To Reactive Oxygen Species Cellular Response To UV-C Cellular Response To Vitamin B1 Cellular Response To Nutrient Levels Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Regulation Of Nucleocytoplasmic Transport Radial Glia Guided Migration Of Cerebellar Granule Cell Cellular Response To Extracellular Stimulus Cellular Response To Stress Regulation Of Intracellular Protein Transport Catabolic Process Traversing Start Control Point Of Mitotic Cell Cycle Response To Vitamin B1 Response To Ether Negative Regulation Of Collateral Sprouting Response To Oxidative Stress Response To Nutrient Levels Regulation Of Intracellular Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Response To Extracellular Stimulus Response To Inorganic Substance Response To UV-C Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Export From Nucleus Cerebellar Granule Cell Differentiation Regulation Of Signal Transduction Positive Regulation Of Macroautophagy Regulation Of Protein Transport Cerebellar Granular Layer Morphogenesis Hydrogen Peroxide Catabolic Process Response To Magnesium Ion Regulation Of Signaling Cellular Response To Antibiotic Negative Regulation Of Cell Cycle Arrest Regulation Of Establishment Of Protein Localization Removal Of Superoxide Radicals Cellular Response To Superoxide Cerebellar Granular Layer Development Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Migration In Hindbrain Cellular Response To Toxic Substance Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle G1/S Phase Transition Protein Destabilization Natural Killer Cell Mediated Cytotoxicity Response To Stress Regulation Of Protein Localization Natural Killer Cell Mediated Immunity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Tagcloud ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	activates anticancer atf4 attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive triple unveiled xenograft yw3
Tagcloud (Difference) ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	activates anticancer atf4 attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive triple unveiled xenograft yw3
Tagcloud (Intersection) ?