PRDX1 and ADH5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PRDX1	ADH5
Description		peroxiredoxin 1	alcohol dehydrogenase 5 (class III), chi polypeptide
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome	Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Cadherin Binding Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity	Alcohol Dehydrogenase (NAD+) Activity Fatty Acid Binding Zinc Ion Binding Electron Transfer Activity Oxidoreductase Activity Formaldehyde Dehydrogenase (NAD+) Activity Identical Protein Binding Metal Ion Binding S-(hydroxymethyl)glutathione Dehydrogenase [NAD(P)+] Activity S-nitrosoglutathione Reductase (NADH) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NADP+) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NAD+) Activity
	Biological Process	Response To Reactive Oxygen Species Skeletal System Development Response To Oxidative Stress Canonical NF-kappaB Signal Transduction Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Regulation Of Stress-activated MAPK Cascade Erythrocyte Homeostasis Natural Killer Cell Mediated Cytotoxicity Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis Fibroblast Proliferation Regulation Of Non-canonical NF-kappaB Signal Transduction	Retinoid Metabolic Process Respiratory System Process Lipid Metabolic Process Fatty Acid Omega-oxidation Response To Lipopolysaccharide Small Molecule Metabolic Process Positive Regulation Of Blood Pressure Formaldehyde Catabolic Process Response To Nitrosative Stress Response To Redox State
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NFE2L2 regulating anti-oxidant/detoxification enzymes	Ethanol oxidation
Drugs		Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form	NADH Lauric acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione
Diseases
GWAS		Body mass index ( 26426971) Hemoglobin ( 32888494)	Alcohol consumption ( 28937693) Alcohol consumption in current drinkers ( 28937693) Alcohol dependence ( 23456092) Blood protein levels ( 30072576) HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		31 interacting genes: ABL1 ADH5 ADRB2 AXIN2 CALM1 CCR4 CDK1 CEBPA CLEC4G EGFR GAPDH IRAK1 IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ	10 interacting genes: APP ARNT CHD3 CSNK2B ESRRA PRDX1 SLC66A2 SNTA1 USP40 VTN
Entrez ID		5052	128
HPRD ID		01458	00064
Ensembl ID		ENSG00000117450	ENSG00000197894
Uniprot IDs		A0A384NPQ2 Q06830	P11766 Q6IRT1
PDB IDs		2RII 3HY2 4XCS 7LJ1 7WET 7WEU 8X71 8X73 8Z54 8Z55 8Z56 8Z57 8Z58 9B7A	1M6H 1M6W 1MA0 1MC5 1MP0 1TEH 2FZE 2FZW 3QJ5 8GV3
Enriched GO Terms of Interacting Partners?		Response To Lipid Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Protein-containing Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Gene Expression Regulation Of Signal Transduction Molecular Adaptor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Lipid Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of DNA Metabolic Process Chromosome Organization Nucleus ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Autophagy Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Response To Cytokine Leukocyte Activation Response To Peptide Negative Regulation Of TORC1 Signaling Enzyme Binding Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Immune Response Regulation Of Macromolecule Biosynthetic Process Regulation Of Growth Cell Activation Involved In Immune Response Positive Regulation Of DNA Metabolic Process	Regulation Of Proteolysis Positive Regulation Of Glycolytic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of ATP Metabolic Process Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Nuclear Receptor Activity Symbiont-containing Vacuole Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Golgi Lumen Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Catabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Nuclear Aryl Hydrocarbon Receptor Complex Response To Oxidative Stress Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Smooth Muscle Cell-matrix Adhesion Rough Endoplasmic Reticulum Lumen Alphav-beta3 Integrin-vitronectin Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Norepinephrine Stimulus Negative Regulation Of Macromolecule Metabolic Process Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling PML Body Syntrophin Complex
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