PRDX1 and SESN1

Number of citations of the paper that reports this interaction (PubMedID 15105503)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PRDX1	SESN1
Description		peroxiredoxin 1	sestrin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol GATOR2 Complex
	Molecular Function	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Cadherin Binding Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor L-leucine Binding
	Biological Process	Response To Reactive Oxygen Species Skeletal System Development Response To Oxidative Stress Canonical NF-kappaB Signal Transduction Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Regulation Of Stress-activated MAPK Cascade Erythrocyte Homeostasis Natural Killer Cell Mediated Cytotoxicity Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis Fibroblast Proliferation Regulation Of Non-canonical NF-kappaB Signal Transduction	Positive Regulation Of Macroautophagy Negative Regulation Of Cell Growth Cellular Response To Amino Acid Starvation Cellular Response To Glucose Starvation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Regulation Of Response To Reactive Oxygen Species Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NFE2L2 regulating anti-oxidant/detoxification enzymes	Amino acids regulate mTORC1 KEAP1-NFE2L2 pathway
Drugs		Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Body mass index ( 26426971) Hemoglobin ( 32888494)	Asthma ( 32296059) Birth weight ( 31043758) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Prostate cancer ( 23535732)
Interacting Genes		31 interacting genes: ABL1 ADH5 ADRB2 AXIN2 CALM1 CCR4 CDK1 CEBPA CLEC4G EGFR GAPDH IRAK1 IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ	3 interacting genes: MIOS PRDX1 WDR24
Entrez ID		5052	27244
HPRD ID		01458	07310
Ensembl ID		ENSG00000117450	ENSG00000080546
Uniprot IDs		A0A384NPQ2 Q06830	Q9Y6P5
PDB IDs		2RII 3HY2 4XCS 7LJ1 7WET 7WEU 8X71 8X73 8Z54 8Z55 8Z56 8Z57 8Z58 9B7A
Enriched GO Terms of Interacting Partners?		Response To Lipid Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Protein-containing Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Gene Expression Regulation Of Signal Transduction Molecular Adaptor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Lipid Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of DNA Metabolic Process Chromosome Organization Nucleus ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Autophagy Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Response To Cytokine Leukocyte Activation Response To Peptide Negative Regulation Of TORC1 Signaling Enzyme Binding Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Immune Response Regulation Of Macromolecule Biosynthetic Process Regulation Of Growth Cell Activation Involved In Immune Response Positive Regulation Of DNA Metabolic Process	GATOR2 Complex Positive Regulation Of TORC1 Signaling Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Oligodendrocyte Progenitor Proliferation Regulation Of TOR Signaling Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Central Nervous System Myelin Formation Lysosomal Membrane Regulation Of Intracellular Signal Transduction Removal Of Superoxide Radicals Erythrocyte Homeostasis Response To Nutrient Levels Lysosome Myelin Assembly Vacuolar Membrane Hydrogen Peroxide Catabolic Process Antioxidant Activity Protein K6-linked Ubiquitination Regulation Of Signal Transduction Peroxidase Activity Hydrogen Peroxide Metabolic Process Cell Population Proliferation Myeloid Cell Homeostasis Negative Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Stress-activated MAPK Cascade Cell Redox Homeostasis Natural Killer Cell Mediated Immunity Superoxide Metabolic Process Natural Killer Cell Mediated Cytotoxicity Regulation Of Cell Communication Regulation Of Stress-activated Protein Kinase Signaling Cascade Fibroblast Proliferation Regulation Of Signaling Oligodendrocyte Differentiation Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Natural Killer Cell Activation Canonical NF-kappaB Signal Transduction Protein Localization To Lysosome
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