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PRDX1 and PPP2R1B
Number of citations of the paper that reports this interaction (PubMedID
17540176
)
58
Data Source:
HPRD
(in vivo)
PRDX1
PPP2R1B
Description
peroxiredoxin 1
protein phosphatase 2 scaffold subunit Abeta
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Melanosome
Extracellular Exosome
Protein Phosphatase Type 2A Complex
Nucleus
Cytoplasm
Cytosol
Membrane Raft
Extracellular Exosome
Molecular Function
RNA Binding
Peroxidase Activity
Protein Binding
Thioredoxin Peroxidase Activity
Antioxidant Activity
Oxidoreductase Activity
Identical Protein Binding
Cadherin Binding
Peroxiredoxin Activity
Thioredoxin-dependent Peroxiredoxin Activity
Protein Binding
Protein Phosphatase Regulator Activity
Biological Process
Response To Reactive Oxygen Species
Skeletal System Development
Response To Oxidative Stress
Canonical NF-kappaB Signal Transduction
Cell Population Proliferation
Removal Of Superoxide Radicals
Natural Killer Cell Activation
Regulation Of Stress-activated MAPK Cascade
Erythrocyte Homeostasis
Natural Killer Cell Mediated Cytotoxicity
Hydrogen Peroxide Catabolic Process
Leukocyte Activation
Cell Redox Homeostasis
Fibroblast Proliferation
Regulation Of Non-canonical NF-kappaB Signal Transduction
Spindle Assembly
Meiotic Sister Chromatid Cohesion, Centromeric
Apoptotic Process Involved In Morphogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NFE2L2 regulating anti-oxidant/detoxification enzymes
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Zinc
Copper
Artenimol
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Body mass index (
26426971
)
Hemoglobin (
32888494
)
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Asthma (
31619474
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Brain morphology (MOSTest) (
32665545
)
Fish- and plant-related diet (
32066663
)
HDL cholesterol levels (
32203549
)
Mean spheric corpuscular volume (
32888494
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Red blood cell count (
32888494
)
Interacting Genes
31 interacting genes:
ABL1
ADH5
ADRB2
AXIN2
CALM1
CCR4
CDK1
CEBPA
CLEC4G
EGFR
GAPDH
IRAK1
IRF3
LUC7L
MTRNR2L1
MYC
MYD88
PPP2R1A
PPP2R1B
PRDX4
PTEN
PTGER4
SESN1
SESN2
SH2D1B
SMARCD1
SNCA
TERF1
UBE3A
VHL
YWHAQ
42 interacting genes:
AKAP9
ANXA5
BHLHE41
BSG
CDK1
CDK4
CEP43
CFTR
CLOCK
CRY1
CRY2
CSNK2B
DELEC1
EEF2
FBXW11
HDAC1
HSPD1
JAK2
MCM3
OGT
PARK7
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5C
PPP2R5D
PPP2R5E
PRDX1
PRDX2
RAB11A
RAB18
RAB7A
RALA
RELA
RORC
SET
SGO1
SGO2
STRN
STRN3
UBC
UNC5B
Entrez ID
5052
5519
HPRD ID
01458
04384
Ensembl ID
ENSG00000117450
ENSG00000137713
Uniprot IDs
A0A384NPQ2
Q06830
P30154
PDB IDs
2RII
3HY2
4XCS
7LJ1
7WET
7WEU
8X71
8X73
8Z54
8Z55
8Z56
8Z57
8Z58
9B7A
Enriched GO Terms of Interacting Partners
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Response To Lipid
Regulation Of Multicellular Organismal Process
Intracellular Signal Transduction
Intracellular Signaling Cassette
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Identical Protein Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
MAPK Cascade
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
Positive Regulation Of Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Signal Transduction
Protein-containing Complex
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Gene Expression
Regulation Of Signal Transduction
Molecular Adaptor Activity
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Cellular Response To Lipid
Negative Regulation Of Metabolic Process
Regulation Of Cell Cycle
Regulation Of DNA Metabolic Process
Chromosome Organization
Nucleus
ERK1 And ERK2 Cascade
Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Multicellular Organismal Process
Regulation Of Autophagy
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle Process
Response To Cytokine
Leukocyte Activation
Response To Peptide
Negative Regulation Of TORC1 Signaling
Enzyme Binding
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Intracellular Signal Transduction
Leukocyte Activation Involved In Immune Response
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Growth
Cell Activation Involved In Immune Response
Positive Regulation Of DNA Metabolic Process
Protein Phosphatase Type 2A Complex
Circadian Regulation Of Gene Expression
Protein Phosphatase Regulator Activity
Cytosol
Rhythmic Process
Circadian Rhythm
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Peroxiredoxin Activity
Regulation Of Circadian Rhythm
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Signal Transduction
Signal Transduction
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Meiotic Sister Chromatid Cohesion
Sister Chromatid Cohesion
Cellular Response To Stress
Blue Light Signaling Pathway
DNA (6-4) Photolyase Activity
Deoxyribodipyrimidine Photo-lyase Activity
Blue Light Photoreceptor Activity
Removal Of Superoxide Radicals
FAR/SIN/STRIPAK Complex
Protein Phosphatase Activator Activity
E-box Binding
Positive Regulation Of Circadian Rhythm
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Intracellular Signal Transduction
Intracellular Receptor Signaling Pathway
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Schwann Cell Differentiation
Response To Oxidative Stress
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Glucocorticoid Secretion
Photoperiodism
Regulation Of Programmed Cell Death
Response To Reactive Oxygen Species
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Apoptotic Signaling Pathway
Protein Phosphatase 2A Binding
Thioredoxin-dependent Peroxiredoxin Activity
Nucleotide Binding
Cytoplasm
Positive Regulation Of Cell Cycle G2/M Phase Transition
Regulation Of Signal Transduction
Negative Regulation Of Neuron Apoptotic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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