PRDX1 and AXIN2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		PRDX1	AXIN2
Description		peroxiredoxin 1	axin 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome	Nucleus Cytoplasm Centrosome Cytosol Plasma Membrane Beta-catenin Destruction Complex Protein-containing Complex
	Molecular Function	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Cadherin Binding Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity	Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Molecular Adaptor Activity I-SMAD Binding
	Biological Process	Response To Reactive Oxygen Species Skeletal System Development Response To Oxidative Stress Canonical NF-kappaB Signal Transduction Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Regulation Of Stress-activated MAPK Cascade Erythrocyte Homeostasis Natural Killer Cell Mediated Cytotoxicity Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis Fibroblast Proliferation Regulation Of Non-canonical NF-kappaB Signal Transduction	Osteoblast Differentiation Somitogenesis Intramembranous Ossification Secondary Heart Field Specification Aortic Valve Morphogenesis Mitral Valve Morphogenesis Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Dorsal/ventral Axis Specification Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Odontogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Maintenance Of DNA Repeat Elements Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Cell Development Response To Steroid Hormone Canonical Wnt Signaling Pathway Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Dexamethasone Stimulus Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NFE2L2 regulating anti-oxidant/detoxification enzymes	TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases
Drugs		Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Oligodontia-colorectal cancer syndrome Tooth agenesis; Hypodontia
GWAS		Body mass index ( 26426971) Hemoglobin ( 32888494)	Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Refractive error ( 32231278)
Interacting Genes		31 interacting genes: ABL1 ADH5 ADRB2 AXIN2 CALM1 CCR4 CDK1 CEBPA CLEC4G EGFR GAPDH IRAK1 IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ	56 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 FXR1 FXR2 GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SIAH1 SMAD1 SMAD3 SMAD7 SNCA STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648
Entrez ID		5052	8313
HPRD ID		01458	04935
Ensembl ID		ENSG00000117450	ENSG00000168646
Uniprot IDs		A0A384NPQ2 Q06830	B7ZKL5 E7ES00 Q9Y2T1
PDB IDs		2RII 3HY2 4XCS 7LJ1 7WET 7WEU 8X71 8X73 8Z54 8Z55 8Z56 8Z57 8Z58 9B7A	8HEO
Enriched GO Terms of Interacting Partners?		Response To Lipid Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Protein-containing Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Gene Expression Regulation Of Signal Transduction Molecular Adaptor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Lipid Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of DNA Metabolic Process Chromosome Organization Nucleus ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Autophagy Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Response To Cytokine Leukocyte Activation Response To Peptide Negative Regulation Of TORC1 Signaling Enzyme Binding Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Immune Response Regulation Of Macromolecule Biosynthetic Process Regulation Of Growth Cell Activation Involved In Immune Response Positive Regulation Of DNA Metabolic Process	Beta-catenin Destruction Complex Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Binding Regulation Of Wnt Signaling Pathway I-SMAD Binding Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Cell-cell Junction Organization Heteromeric SMAD Protein Complex Regulation Of Cartilage Development Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signalosome Centrosome Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Ureteric Bud Development Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleus Cell Junction Organization Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Mesonephric Epithelium Development Mesonephric Tubule Development Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Epithelial To Mesenchymal Transition Regulation Of Nucleocytoplasmic Transport Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process SMAD Protein Signal Transduction Positive Regulation Of Catabolic Process Response To Growth Factor Regulation Of Long-term Neuronal Synaptic Plasticity Kidney Epithelium Development Catenin Complex Regulation Of Intracellular Protein Transport Regulation Of Osteoblast Differentiation Identical Protein Binding Protein Binding Positive Regulation Of Cartilage Development Regulation Of Protein Localization To Nucleus Protein Catabolic Process Positive Regulation Of Protein Localization To Centrosome SMAD Protein Complex Regulation Of Protein Export From Nucleus
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