ANXA1 and NOP58

Number of citations of the paper that reports this interaction (PubMedID 37001908)
48

Data Source:
BioGRID (unspecified method)

		ANXA1	NOP58
Description		annexin A1	NOP58 ribonucleoprotein
Image
GO Annotations	Cellular Component	Cornified Envelope Phagocytic Cup Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Actin Filament Plasma Membrane Adherens Junction Focal Adhesion Cilium Cell Surface Endosome Membrane Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Membrane Extracellular Matrix Cytoplasmic Vesicle Motile Cilium Early Endosome Membrane Vesicle Sarcolemma Cell Projection Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytosol Cajal Body Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Pre-snoRNP Complex Ribonucleoprotein Complex
	Molecular Function	Phosphatidylserine Binding Phospholipase Inhibitor Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Lipid Binding Phospholipase A2 Inhibitor Activity Metal Ion Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	TFIID-class Transcription Factor Complex Binding RNA Binding Protein Binding SnoRNA Binding ATPase Binding
	Biological Process	Neutrophil Homeostasis Adaptive Immune Response Immune System Process Monocyte Chemotaxis Regulation Of Leukocyte Migration Phagocytosis Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cell Shape Myoblast Migration Involved In Skeletal Muscle Regeneration Peptide Cross-linking Actin Cytoskeleton Organization Keratinocyte Differentiation Positive Regulation Of Vesicle Fusion Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Neutrophil Apoptotic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Neutrophil Activation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Exocytosis Alpha-beta T Cell Differentiation Regulation Of Hormone Secretion Arachidonate Secretion Regulation Of Inflammatory Response Negative Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Cellular Response To Glucocorticoid Stimulus Granulocyte Chemotaxis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Wound Healing Neutrophil Clearance Cell-cell Adhesion Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	RRNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis SnoRNA Localization
Pathways		G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Smooth Muscle Contraction Interleukin-4 and Interleukin-13 signaling Developmental Lineage of Pancreatic Ductal Cells	SUMOylation of RNA binding proteins rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Amcinonide Fluocinolone acetonide Hydrocortisone Methylprednisolone Clobetasol propionate Budesonide Dexamethasone Cortisone acetate Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate Prednisolone phosphate Dexamethasone acetate Betamethasone phosphate
Diseases
GWAS		Chronotype ( 30696823) Cortical surface area ( 32963231) Cortical volume ( 32963231) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Urate levels in obese individuals ( 25811787)
Interacting Genes		80 interacting genes: AP2A2 APBB1 BUB3 CCN1 CCT7 CD274 CD44 CDC5L CDH13 CLIC1 CLTC COPS6 CORO1C CSAD CZIB DAPK3 DDB1 DDX3X DYSF EEF2 EGFR EIF2S1 EPHA2 ERG28 FAF1 FGFBP1 FLOT1 FLOT2 FPR1 G3BP2 GAPDH GAPDHS GNL3 HMGA1 HSP90AB1 HSPB1 IFIT1 IFIT3 IGF2BP1 IGF2BP3 KLHL23 KMT2B KRT8 LGALS3 LGALS8 LMNA LMO7 LNPK LRIF1 MEIS2 MEN1 MYBBP1A MYH10 MYH9 NOP58 OTUB1 PARP1 PARP9 PHB2 PRKCI RCC2 S100A11 SRC STRAP SUMO2 TCP1 TGM2 TOE1 TRAF4 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UGDH UNC119 USP7 XRCC1 XRCC6 YWHAQ	8 interacting genes: ANXA1 CEBPA CSNK2A1 MAP4 OGT PTEN UBE2I WDR3
Entrez ID		301	51602
HPRD ID		01060	11036
Ensembl ID		ENSG00000135046	ENSG00000055044
Uniprot IDs		P04083 Q5TZZ9	Q9Y2X3
PDB IDs		1AIN 1BO9 1QLS 5VFW	7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Focal Adhesion Negative Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Cytosol Nucleus RNA Binding Positive Regulation Of Protein Localization Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Extracellular Exosome MRNA 5'-UTR Binding Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Regulation Of Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of DNA Metabolic Process Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Cell Adhesion Perinuclear Region Of Cytoplasm Biological Process Involved In Interaction With Host Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Cellular Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lamellipodium Negative Regulation Of Protein Metabolic Process Regulation Of Signaling Intracellular Signal Transduction Response To Stress Regulation Of Gene Expression Disordered Domain Specific Binding Flotillin Complex Protein Binding	Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm PML Body Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sin3-type Complex Macromolecule Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cell Development RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Membraneless Organelle Assembly Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly SUMO Conjugating Enzyme Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly U11/U12 SnRNP Lipid Binding Positive Regulation Of Protein Metabolic Process Chromatin DNA Binding Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II Response To Vitamin B2 C/EBP Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Negative Regulation Of Non-motile Cilium Assembly Microtubule Stabilizing Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Catalytic Step 2 Spliceosome Organelle Organization Protein Localization To Vacuole Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Migration Negative Regulation Of Developmental Process CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Translational Initiation Protein Kinase CK2 Complex
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