ANXA1 and DAPK3

Number of citations of the paper that reports this interaction (PubMedID 37001908)
48

Data Source:
BioGRID (unspecified method)

		ANXA1	DAPK3
Description		annexin A1	death associated protein kinase 3
Image
GO Annotations	Cellular Component	Cornified Envelope Phagocytic Cup Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Actin Filament Plasma Membrane Adherens Junction Focal Adhesion Cilium Cell Surface Endosome Membrane Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Membrane Extracellular Matrix Cytoplasmic Vesicle Motile Cilium Early Endosome Membrane Vesicle Sarcolemma Cell Projection Extracellular Exosome	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cilium PML Body Midbody
	Molecular Function	Phosphatidylserine Binding Phospholipase Inhibitor Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Lipid Binding Phospholipase A2 Inhibitor Activity Metal Ion Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Kinase Activity Transferase Activity Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Protein Serine Kinase Activity
	Biological Process	Neutrophil Homeostasis Adaptive Immune Response Immune System Process Monocyte Chemotaxis Regulation Of Leukocyte Migration Phagocytosis Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cell Shape Myoblast Migration Involved In Skeletal Muscle Regeneration Peptide Cross-linking Actin Cytoskeleton Organization Keratinocyte Differentiation Positive Regulation Of Vesicle Fusion Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Neutrophil Apoptotic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Neutrophil Activation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Exocytosis Alpha-beta T Cell Differentiation Regulation Of Hormone Secretion Arachidonate Secretion Regulation Of Inflammatory Response Negative Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Cellular Response To Glucocorticoid Stimulus Granulocyte Chemotaxis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Wound Healing Neutrophil Clearance Cell-cell Adhesion Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Translation Protein Phosphorylation Apoptotic Process Regulation Of Smooth Muscle Contraction Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Shape Regulation Of Autophagy Negative Regulation Of Translation Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Myosin II Filament Organization Protein Autophosphorylation Regulation Of Focal Adhesion Assembly Cellular Response To Type II Interferon Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Cell Motility
Pathways		G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Smooth Muscle Contraction Interleukin-4 and Interleukin-13 signaling Developmental Lineage of Pancreatic Ductal Cells	Caspase activation via Dependence Receptors in the absence of ligand
Drugs		Amcinonide Fluocinolone acetonide Hydrocortisone Methylprednisolone Clobetasol propionate Budesonide Dexamethasone Cortisone acetate Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate Prednisolone phosphate Dexamethasone acetate Betamethasone phosphate	2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Fostamatinib
Diseases
GWAS		Chronotype ( 30696823) Cortical surface area ( 32963231) Cortical volume ( 32963231) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Urate levels in obese individuals ( 25811787)	Age-related macular degeneration ( 23326517) Expressive vocabulary in infants ( 25226531)
Interacting Genes		80 interacting genes: AP2A2 APBB1 BUB3 CCN1 CCT7 CD274 CD44 CDC5L CDH13 CLIC1 CLTC COPS6 CORO1C CSAD CZIB DAPK3 DDB1 DDX3X DYSF EEF2 EGFR EIF2S1 EPHA2 ERG28 FAF1 FGFBP1 FLOT1 FLOT2 FPR1 G3BP2 GAPDH GAPDHS GNL3 HMGA1 HSP90AB1 HSPB1 IFIT1 IFIT3 IGF2BP1 IGF2BP3 KLHL23 KMT2B KRT8 LGALS3 LGALS8 LMNA LMO7 LNPK LRIF1 MEIS2 MEN1 MYBBP1A MYH10 MYH9 NOP58 OTUB1 PARP1 PARP9 PHB2 PRKCI RCC2 S100A11 SRC STRAP SUMO2 TCP1 TGM2 TOE1 TRAF4 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UGDH UNC119 USP7 XRCC1 XRCC6 YWHAQ	18 interacting genes: AATF AK3 ANXA1 ATF4 CDKN1A CHEK2 DAXX GRB14 LMO7 MDM2 MET NEDD4L OGT PAWR PRKCZ RPL34 TCP10L TP53
Entrez ID		301	1613
HPRD ID		01060	04478
Ensembl ID		ENSG00000135046	ENSG00000167657
Uniprot IDs		P04083 Q5TZZ9	B3KNJ3 O43293
PDB IDs		1AIN 1BO9 1QLS 5VFW	1YRP 2J90 3BHY 3BQR 5A6N 5A6O 5VJA
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Focal Adhesion Negative Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Cytosol Nucleus RNA Binding Positive Regulation Of Protein Localization Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Extracellular Exosome MRNA 5'-UTR Binding Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Regulation Of Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of DNA Metabolic Process Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Cell Adhesion Perinuclear Region Of Cytoplasm Biological Process Involved In Interaction With Host Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Cellular Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lamellipodium Negative Regulation Of Protein Metabolic Process Regulation Of Signaling Intracellular Signal Transduction Response To Stress Regulation Of Gene Expression Disordered Domain Specific Binding Flotillin Complex Protein Binding	Regulation Of Programmed Cell Death Cellular Response To Gamma Radiation Leucine Zipper Domain Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Gamma Radiation Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Radiation Negative Regulation Of Cell Communication Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Replicative Senescence Cellular Response To Ionizing Radiation Cellular Response To UV Molecular Function Activator Activity Positive Regulation Of Metabolic Process Cellular Response To Actinomycin D Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Process Cellular Response To Light Stimulus Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Actinomycin D Response To Nutrient Levels Negative Regulation Of Gene Expression Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Cellular Response To UV-C Ubiquitin Protein Ligase Binding Response To Ionizing Radiation Positive Regulation Of Biosynthetic Process Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Signal Transduction In Response To DNA Damage Response To UV Negative Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Negative Regulation Of Protein Metabolic Process Stress-induced Premature Senescence Regulation Of Signaling Negative Regulation Of Biosynthetic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition
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